Detailed view for Bm1_40725

Basic information

TDR Targets ID: 233832
Brugia malayi, UDP-galactose transporter family protein
Source Database / ID:  GenBank

pI: 9.5456 | Length (AA): 319 | MW (Da): 35463 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04142   Nucleotide-sugar transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0090481   GO:pyrimidine nucleotide-sugar transmembrane transport  

GO:0015165   pyrimidine nucleotide sugar transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0000139   Golgi membrane  
GO:0005351   sugar:hydrogen symporter activity  
GO:0005338   nucleotide-sugar transmembrane transporter activity  
GO:0015780   nucleotide-sugar transport  
GO:0008643   carbohydrate transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
178 293 1zcd (A) 56 174 31.00 0.27 0.02 0.240436 2.61
181 296 1zcd (A) 56 174 31.00 0.25 0.02 0.236948 2.61

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127989)

Species Accession Gene Product
Arabidopsis thaliana AT4G35335   Nucleotide-sugar transporter family protein
Brugia malayi Bm1_40725   UDP-galactose transporter family protein
Brugia malayi Bm1_36330   UDP-galactose transporter family protein
Caenorhabditis elegans CELE_ZK896.9   Protein NSTP-5, isoform B
Caenorhabditis elegans CELE_C03H5.2   Protein NSTP-4
Caenorhabditis elegans CELE_M02B1.1   Protein SRF-3, isoform C
Cryptosporidium hominis Chro.20067   nucleotide-sugar transporter (2A681)
Cryptosporidium parvum cgd2_590   nucleotide-sugar transporter, UDP N-acetylglucosamine-like, signal peptide, 9 or more transmembrane domains
Drosophila melanogaster Dmel_CG2675   CG2675 gene product from transcript CG2675-RC
Echinococcus granulosus EgrG_000885800   nucleotide sugar transporter
Echinococcus granulosus EgrG_000513900   UDP N acetylglucosamine transporter
Entamoeba histolytica EHI_050270   UDP-N-acetylglucosamine transporter, putative
Echinococcus multilocularis EmuJ_000513900   UDP N acetylglucosamine transporter
Echinococcus multilocularis EmuJ_000885800   nucleotide sugar transporter
Homo sapiens ENSG00000102100   solute carrier family 35 (UDP-galactose transporter), member A2
Homo sapiens ENSG00000117620   solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
Leishmania braziliensis LbrM.18.0420   UDP-galactose transporter
Leishmania donovani LdBPK_180400.1   UDP-galactose transporter
Leishmania infantum LinJ.18.0400   UDP-galactose transporter
Leishmania major LmjF.18.0400   UDP-galactose transporter
Leishmania mexicana LmxM.18.0400   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_14455   hypothetical protein
Loa Loa (eye worm) LOAG_02557   UDP-galactose transporter
Loa Loa (eye worm) LOAG_13056   hypothetical protein
Loa Loa (eye worm) LOAG_09074   UDP-galactose transporter
Mus musculus ENSMUSG00000027957   solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
Mus musculus ENSMUSG00000031156   solute carrier family 35 (UDP-galactose transporter), member A2
Neospora caninum NCLIV_038800   hypothetical protein
Schistosoma japonicum Sjp_0007790   UDP-N-acetylglucosamine transporter, putative
Schistosoma japonicum Sjp_0085220   UDP-N-acetylglucosamine transporter, putative
Schistosoma mansoni Smp_065770.2   sugar transporter
Schistosoma mansoni Smp_008580   sugar transporter
Schistosoma mansoni Smp_065770.1   sugar transporter
Schmidtea mediterranea mk4.005919.00   UDP-galactose translocator
Schmidtea mediterranea mk4.004310.01   Putative sugar transporter
Schmidtea mediterranea mk4.000675.13   UDP-galactose translocator
Schmidtea mediterranea mk4.003421.03   Putative sugar transporter
Trypanosoma brucei gambiense Tbg972.10.17080   UDP-galactose transporter, putative
Trypanosoma brucei Tb927.10.13900   Nucleotide sugar transporter 1
Trypanosoma congolense TcIL3000_10_11780   UDP-galactose transporter
Trypanosoma congolense TcIL3000.11.16480   CMP-sialic acid transporter, putative
Trypanosoma cruzi TcCLB.511277.400   UDP-galactose transporter
Toxoplasma gondii TGME49_267380   UDP-galactose transporter subfamily protein

Essentiality

Bm1_40725 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13900 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13900 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.13900 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.13900 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_267380 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_40725 (Brugia malayi), UDP-galactose transporter family protein
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