pI: 8.1085 |
Length (AA): 195 |
MW (Da): 21767 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 187 | 3gha (A) | 46 | 222 | 12.00 | 0.0000000078 | 0.05 | 0.980546 | -0.18 |
2 | 188 | 4pwo (A) | 103 | 279 | 14.00 | 0.00000053 | 0.46 | 1.00967 | 0.09 |
13 | 174 | 3bci (A) | 14 | 168 | 9.00 | 0.00000000008 | 0.08 | 0.856469 | -0.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128734)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G12890 | Gamma interferon responsive lysosomal thiol (GILT) reductase family protein |
Arabidopsis thaliana | AT4G12960 | Gamma interferon responsive lysosomal thiol (GILT) reductase family protein |
Arabidopsis thaliana | AT4G12900 | Gamma interferon responsive lysosomal thiol (GILT) reductase family protein |
Arabidopsis thaliana | AT4G12870 | Gamma interferon responsive lysosomal thiol (GILT) reductase family protein |
Arabidopsis thaliana | AT5G01580 | protein OAS HIGH ACCUMULATION 1 |
Brugia malayi | Bm1_19580 | Prion-like- |
Brugia malayi | Bm1_57365 | interferon gamma-inducible thiol reductase |
Caenorhabditis elegans | CELE_ZK669.2 | Protein ZK669.2 |
Caenorhabditis elegans | CELE_F37H8.5 | Protein F37H8.5 |
Caenorhabditis elegans | CELE_K07D4.8 | Protein PQN-48 |
Drosophila melanogaster | Dmel_CG13822 | CG13822 gene product from transcript CG13822-RA |
Drosophila melanogaster | Dmel_CG9796 | CG9796 gene product from transcript CG9796-RA |
Drosophila melanogaster | Dmel_CG41378 | CG41378 gene product from transcript CG41378-RE |
Drosophila melanogaster | Dmel_CG9427 | CG9427 gene product from transcript CG9427-RB |
Drosophila melanogaster | Dmel_CG10157 | CG10157 gene product from transcript CG10157-RA |
Homo sapiens | ENSG00000216490 | interferon, gamma-inducible protein 30 |
Loa Loa (eye worm) | LOAG_11956 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14183 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03543 | interferon gamma-inducible thiol reductase |
Mus musculus | ENSMUSG00000031838 | interferon gamma inducible protein 30 |
Neospora caninum | NCLIV_025860 | hypothetical protein |
Oryza sativa | 4332535 | Os03g0295800 |
Schmidtea mediterranea | mk4.000755.00 | |
Toxoplasma gondii | TGME49_261630 | gamma interferon inducible lysosomal thiol reductase (GILT) protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_261630 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.