Detailed view for Bm1_50230

Basic information

TDR Targets ID: 234672
Brugia malayi, Peptidase C13 family protein
Source Database / ID:  GenBank

pI: 7.8476 | Length (AA): 442 | MW (Da): 50466 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01650   Peptidase C13 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008233   peptidase activity  
GO:0004197   cysteine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

Lysosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 435 4d3z (A) 31 436 43.00 0 1 1.47891 -1.02
22 435 5h0i (A) 55 472 38.00 0 1 1.40665 -0.88
23 433 4fgu (A) 28 429 44.00 0 1 1.51296 -0.81
23 433 4nol (A) 30 431 47.00 0 1 1.46896 -0.77

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130263)

Species Accession Gene Product
Arabidopsis thaliana AT1G62710   vacuolar-processing enzyme beta
Arabidopsis thaliana AT3G20210   delta vacuolar processing enzyme
Arabidopsis thaliana AT2G25940   alpha-vacuolar processing enzyme
Arabidopsis thaliana AT4G32940   vacuolar-processing enzyme gamma
Brugia malayi Bm1_50230   Peptidase C13 family protein
Caenorhabditis elegans CELE_T28H10.3   Protein T28H10.3
Homo sapiens ENSG00000100600   legumain
Loa Loa (eye worm) LOAG_02771   peptidase C13 family protein
Mus musculus ENSMUSG00000021190   legumain
Oryza sativa 4330133   Os02g0644000
Oryza sativa 4339804   Os05g0593900
Oryza sativa 4324683   Os01g0559600
Oryza sativa 4336523   Os04g0537900
Onchocerca volvulus OVOC7039   Legumain homolog
Schistosoma japonicum Sjp_0001230   ko:K01369 legumain [EC3.4.22.34], putative
Schistosoma mansoni Smp_179170   family C13 non-peptidase homologue (C13 family)
Schistosoma mansoni Smp_075800.2   hemoglobinase (C13 family)
Schistosoma mansoni Smp_075800.1   hemoglobinase (C13 family)
Schistosoma mansoni Smp_075790   hypothetical protein
Trichomonas vaginalis TVAG_385340   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_426660   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_185540   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_305110   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_068410   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_050390   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_328450   Clan CD, family C13, legumain-like cysteine peptidase

Essentiality

Bm1_50230 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T28H10.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens legumain Compounds References
Mus musculus legumain Compounds References
Ixodes ricinus Legumain-like protease Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.2867 0.3749 0.3749
0.276 0.5347 1
0.3325 0.5296 0.7013
0.0183 0.4 0.4
0.3085 0.6797 0.6797
0.3085 0.6797 0.6797
0.0688 0.8226 1
0.3085 0.6797 0.6797
0.2867 0.3749 0.3749
0.0482 0.4631 0.4875
0.3085 0.6797 0.6797
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.1166 0.996 1
0.276 0.5347 1
0.3325 0.5296 0.7013
0.0151 0.3734 0.71
0.0183 0.3639 0.7548
0.345347 1 1
0.301364 1 1
0.3085 0.6797 0.6797
0.3325 0.5296 0.7013
0.301364 1 1
0.3085 0.6797 0.6797
0.1538 0.9633 0.9845
0.1773 0.3572 0.5
0.1538 0.9633 0.9845
0.0295 0.6123 1
0.305 0.8982 1
0.0443 0.3157 0.3157
0.3325 0.5296 0.7013
0.0792 0.4512 1
0.0524 0.9707 0.5
0.1773 0.3572 0.5
0.2867 0.3749 0.3749
0.3085 0.6797 0.6797
0.3325 0.5296 0.7013
0.0814 0.6038 0.6038
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.0512 0.6053 1
0.0351 0.677 0.8036
0.1538 0.9633 0.9845
0.0595 0.8149 0.8149
0.1081 0.6805 1
0.3085 0.6797 0.6797
0.3325 0.5296 0.7013
0.3085 0.6797 0.6797
0.0183 0.4593 1
0.0905 0.2652 0.2646
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.0585 0.3414 1
0.0183 0.5348 1
0.2867 0.3749 0.3749
0.3209 0.7271 0.7271
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.1773 0.3572 0.5
0.3085 0.6797 0.6797
0.3325 0.5296 0.7013
0.0514 0.4617 0.4872
0.3085 0.6797 0.6797
0.305 0.8982 1
0.0314 0.3488 1
0.1166 0.996 1
0.3688 0.392 1
0.239675 1 1
0.3325 0.5296 0.7013
0.1538 0.9633 0.9845
0.1486 0.5655 1
0.3688 0.392 1
0.3325 0.5296 0.7013
0.1538 0.9633 0.9845
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.0183 0.4693 1
0.1166 0.996 1
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.3085 0.6797 0.6797
0.3325 0.5296 0.7013
0.2518 0.524 1
0.0501 0.6519 1
0.3085 0.6797 0.6797
0.3085 0.6797 0.6797
0.0505 0.538 1
0.0294 0.3957 1
0.3325 0.5296 0.7013
0.1538 0.9633 0.9845
0.0183 0.5884 1
0.3688 0.392 1
0.1538 0.9633 0.9845
0.3325 0.5296 0.7013
0.301364 1 1
0.2867 0.3749 0.3749
0.3085 0.6797 0.6797
0.301364 1 1
0.3085 0.6797 0.6797
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013
0.3325 0.5296 0.7013

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_50230 (Brugia malayi), Peptidase C13 family protein
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