Detailed view for Bm1_45395

Basic information

TDR Targets ID: 235069
Brugia malayi, sodium-independent organic anion transporter family protein
Source Database / ID:  GenBank

pI: 8.2094 | Length (AA): 636 | MW (Da): 71058 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 10

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03137   Organic Anion Transporter Polypeptide (OATP) family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
452 494 1uvg (A) 12 53 24.00 0 0.25 0.18901 0.55
456 486 1ldt (L) 4 33 37.00 0 0.45 0.297142 0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127940)

Species Accession Gene Product
Brugia malayi Bm1_45395   sodium-independent organic anion transporter family protein
Brugia malayi Bm1_19375   sodium-independent organic anion transporter family protein
Caenorhabditis elegans CELE_Y70G10A.3   Protein Y70G10A.3
Caenorhabditis elegans CELE_F53B1.8   Protein F53B1.8
Drosophila melanogaster Dmel_CG31634   Organic anion transporting polypeptide 26F
Drosophila melanogaster Dmel_CG3811   Organic anion transporting polypeptide 30B
Echinococcus granulosus EgrG_000970200   organic anion transporting polypeptide 30B
Echinococcus multilocularis EmuJ_000970200   organic anion transporting polypeptide 30B
Homo sapiens ENSG00000173930   solute carrier organic anion transporter family, member 4C1
Homo sapiens ENSG00000101187   solute carrier organic anion transporter family, member 4A1
Homo sapiens ENSG00000137571   solute carrier organic anion transporter family, member 5A1
Loa Loa (eye worm) LOAG_04909   hypothetical protein
Loa Loa (eye worm) LOAG_04794   sodium-independent organic anion transporter
Mus musculus ENSMUSG00000025938   solute carrier organic anion transporter family, member 5A1
Mus musculus ENSMUSG00000038963   solute carrier organic anion transporter family, member 4a1
Mus musculus 227394   solute carrier organic anion transporter family, member 4C1
Onchocerca volvulus OVOC2574  
Onchocerca volvulus OVOC8406  
Schistosoma japonicum Sjp_0300450   Solute carrier organic anion transporter family member 5A1, putative
Schistosoma mansoni Smp_159140   organic anion transporter
Schmidtea mediterranea mk4.000219.00  
Schmidtea mediterranea mk4.024887.00   Solute carrier organic anion transporter family member 5A1
Schmidtea mediterranea mk4.001004.10  
Schmidtea mediterranea mk4.016496.00   Putative organic anion transporter
Schmidtea mediterranea mk4.020124.00   Putative organic anion transporter
Schmidtea mediterranea mk4.001004.07  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier organic anion transporter family, member 4C1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0059 0.792 0.792
0.0105 0.541 0.5326
0.0059 0.2526 1
0.0291 0.2929 0.7926
0.0056 0.2904 1
0.0031 0.3928 0.3855
0.0114 0.2612 0.4133
0.0171 0.3182 0.7285
0.0169 0.7121 0.7121
0.0303 0.3624 0.9791
0.0082 0.5309 0.5309
0.0289 0.3122 0.843
0.0062 0.2788 0.5992
0.0121 0.9935 0.9921
0.0124 0.7525 0.7525
0.0115 0.257 1
0.0052 0.2612 0.7841
0.0223 0.2642 0.7271
0.0109 0.2883 0.3647
0.0027 0.8069 1
0.0028 0.4386 0.3882
0.0066 0.4263 0.4263
0.0119 0.2571 1
0.0056 0.5904 0.6375
0.0032 0.4608 0.4608
0.0065 0.2904 0.3062
0.0522 0.2894 0.9731
0.0154 0.2772 0.7007
0.011 0.3161 1
0.0029 0.4068 0.3592
0.0111 0.2619 0.3778
0.0312 0.3548 0.9597
0.0114 0.47 0.47
0.0056 0.2543 0.2543
0.0318 0.3345 0.9047
0.011 0.3556 0.4058
0.0172 0.3041 0.7241
0.0067 0.813 0.813
0.0062 0.2869 0.3157
0.012 0.7415 0.7415
0.0029 0.4393 0.389
0.0259 0.2662 0.7204
0.0067 0.2575 0.6803
0.0056 0.7719 0.7719
0.0112 0.2869 0.4116
0.0067 0.2657 1
0.0108 0.3627 0.4354
0.0165 0.2771 0.5873
0.0056 0.5904 0.6375
0.0562 0.2882 0.973
0.0292459 1 1
0.0562 0.2882 0.973
0.0257 0.3022 0.8161
0.0029 0.4138 0.3645
0.0067 0.2575 0.6803
0.0056 0.696 0.6955
0.0061 0.2633 0.2543
0.0067 0.2575 0.6803
0.011 0.3161 1
0.0111 0.2619 0.3778
0.00673401 0.271722 1
0.0153 0.3273 0.7115
0.0181 0.595 0.6882
0.0112 0.2869 0.4116
0.0117 0.7104 1
0.0028 0.8095 1
0.0062 0.6355 0.5833
0.0056 0.2631 0.2626
0.0055 0.5718 0.5718
0.0109 0.2883 0.3647
0.00558431 1 1
0.010998 0.477701 1
0.0056 0.2904 1
0.0116 0.2569 0.4237
0.0111 0.2619 0.3778
0.0117 0.7104 1
0.012 0.3841 0.4388
0.0259 0.2824 0.7623
0.0133 0.272 0.2981
0.0562 0.2882 0.973
0.0034 0.5451 0.5451
0.003 0.4205 0.3709
0.0056 0.2763 0.2696
0.012 0.3841 0.4388
0.0147087 0.2527 0.251039
0.0562 0.2882 0.973
0.011 0.376 0.4388
0.0115 0.257 1
0.0028 0.8577 1
0.0067 0.2575 0.6803
0.0288 0.3553 0.8265
0.0299 0.3745 1
0.0254 0.7984 0.7984
0.0231 0.8539 0.9889
0.0193437 0.265024 0.264404
0.0067 0.2575 0.6803
0.0111 0.2619 0.3778
0.0319 0.3357 0.9087
0.0114 0.4413 0.4592
0.0128 0.2556 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_45395 (Brugia malayi), sodium-independent organic anion transporter family protein
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