Detailed view for Bm1_18515

Basic information

TDR Targets ID: 235419
Brugia malayi, ADP,ATP carrier protein, heart/skeletal muscle isoform T1
Source Database / ID:  GenBank

pI: 10.2608 | Length (AA): 315 | MW (Da): 34773 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0005488   binding  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

Calcium signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 311 1okc (A) 6 293 59.00 0 1 1.55104 0.27
27 315 4c9h (A) 23 312 58.00 0 1 1.47546 0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126841)

Species Accession Gene Product
Arabidopsis thaliana AT5G56450   probable ADP,ATP carrier protein
Arabidopsis thaliana AT4G28390   ADP/ATP carrier 3 protein
Arabidopsis thaliana AT3G08580   ADP,ATP carrier protein 1
Arabidopsis thaliana AT5G13490   ADP/ATP carrier protein 2
Babesia bovis BBOV_III010060   adenine nucleotide translocase
Brugia malayi Bm1_42895   ADP/ATP translocase
Brugia malayi Bm1_18515   ADP,ATP carrier protein, heart/skeletal muscle isoform T1
Candida albicans CaO19.8545   similar to S. cerevisiae PET9 (YBL030C) mitochondrial inner membrane ATP/ADP translocator
Candida albicans CaO19.930   similar to S. cerevisiae PET9 (YBL030C) mitochondrial inner membrane ATP/ADP translocator
Caenorhabditis elegans CELE_W02D3.6   Protein ANT-1.2
Caenorhabditis elegans CELE_T27E9.1   Protein ANT-1.1, isoform B
Caenorhabditis elegans CELE_K01H12.2   Protein ANT-1.3
Caenorhabditis elegans CELE_T01B11.4   Protein ANT-1.4
Cryptosporidium hominis Chro.80141   ADP/ATP carrier
Cryptosporidium parvum cgd8_1210   mitochondrial ADP/ATP-transporter, integral membrane protein with 4 transmembrane domains
Dictyostelium discoideum DDB_G0267454   ADP/ATP translocase
Drosophila melanogaster Dmel_CG1683   Adenine nucleotide translocase 2
Drosophila melanogaster Dmel_CG16944   stress-sensitive B
Echinococcus granulosus EgrG_000610400   atp:adp antiporter
Echinococcus multilocularis EmuJ_000610400   atp:adp antiporter
Homo sapiens ENSG00000151475   solute carrier family 25 (mitochondrial carrier
Homo sapiens 293   solute carrier family 25 (mitochondrial carrier
Homo sapiens ENSG00000151729   solute carrier family 25 (mitochondrial carrier
Homo sapiens ENSG00000005022   solute carrier family 25 (mitochondrial carrier
Leishmania braziliensis LbrM.19.0520   ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative
Leishmania braziliensis LbrM.19.0510   ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative
Leishmania donovani LdBPK_190200.1   ADP,ATP carrier protein 1, mitochondrial precursor, putative
Leishmania infantum LinJ.19.0200   ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative
Leishmania infantum LinJ.19.0190   ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative
Leishmania major LmjF.19.0200   ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative
Leishmania major LmjF.19.0210   ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative
Leishmania mexicana LmxM.19.0210   ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative
Leishmania mexicana LmxM.19.0200   ADP,ATP carrier protein 1, mitochondrial precursor, putative
Loa Loa (eye worm) LOAG_02370   ADP/ATP translocase
Loa Loa (eye worm) LOAG_07239   ADP/ATP carrier protein
Mus musculus 73333   solute carrier family 25 (mitochondrial carrier
Mus musculus 11739   solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
Mus musculus ENSMUSG00000016319   solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
Neospora caninum NCLIV_060320   mitochondrial carrier domain-containing protein, putative
Neospora caninum NCLIV_066020   hypothetical protein
Oryza sativa 9270318   Os05g0539600
Oryza sativa 4338353   Os05g0302700
Oryza sativa 4330539   Os02g0718900
Onchocerca volvulus OVOC7706   Putative adp,ATP carrier protein
Onchocerca volvulus OVOC9982   Putative adp,ATP carrier protein
Plasmodium berghei PBANKA_0520200   ADP/ATP transporter on adenylate translocase, putative
Plasmodium falciparum PF3D7_1037300   ADP/ATP transporter on adenylate translocase
Plasmodium knowlesi PKNH_0621800   ADP/ATP transporter on adenylate translocase, putative
Plasmodium vivax PVX_250300   unspecified product
Plasmodium vivax PVX_110895   ADP/ATP transporter on adenylate translocase, putative
Plasmodium yoelii PY03882   adenine nucleotide translocase
Saccharomyces cerevisiae YBR085W   ADP/ATP carrier protein AAC3
Saccharomyces cerevisiae YBL030C   ADP/ATP carrier protein PET9
Schistosoma japonicum Sjp_0062310   ko:K05863 solute carrier family 25 (mitochondrial carrier; adenine nucleotide, putative
Schistosoma mansoni Smp_079220   ADPATP carrier protein
Schmidtea mediterranea mk4.002697.00   Putative adp,ATP carrier protein
Trypanosoma brucei gambiense Tbg972.10.17990   mitochondrial carrier protein, putative,ADP/ATP translocase 1, putative
Trypanosoma brucei Tb927.10.14820   Mitochondrial ADP/ATP carrier protein 5c
Trypanosoma brucei Tb927.10.14840   Mitochondrial ADP/ATP carrier protein 5a
Trypanosoma brucei Tb927.10.14830   Mitochondrial ADP/ATP carrier protein 5b
Trypanosoma congolense TcIL3000_10_12690   Mitochondrial ADP/ATP carrier protein 5c, putative
Trypanosoma cruzi TcCLB.506211.160   Mitochondrial ADP/ATP carrier protein 5, putative
Trypanosoma cruzi TcCLB.511289.70   Mitochondrial ADP/ATP carrier protein 5, putative
Toxoplasma gondii TGME49_300360   ADP/ATP translocase
Toxoplasma gondii TGME49_249900   adenine nucleotide translocator, putative
Toxoplasma gondii TGME49_237700   ADP/ATP carrier protein, putative
Theileria parva TP02_0141   adenine nucleotide translocase, putative

Essentiality

Bm1_18515 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14820 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14820 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14820 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.14820 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T27E9.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T27E9.1 Caenorhabditis elegans larval arrest wormbase
CELE_T27E9.1 Caenorhabditis elegans slow growth wormbase
CELE_T27E9.1 Caenorhabditis elegans sterile wormbase
CELE_K01H12.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K01H12.2 Caenorhabditis elegans larval arrest wormbase
CELE_K01H12.2 Caenorhabditis elegans larval lethal wormbase
CELE_K01H12.2 Caenorhabditis elegans slow growth wormbase
CELE_K01H12.2 Caenorhabditis elegans sterile wormbase
CELE_T01B11.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_T01B11.4 Caenorhabditis elegans larval arrest wormbase
CELE_T01B11.4 Caenorhabditis elegans slow growth wormbase
CELE_T01B11.4 Caenorhabditis elegans sterile wormbase
YBL030C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0520200 Plasmodium berghei Slow plasmo
TGME49_237700 Toxoplasma gondii Essentiality uncertain sidik
TGME49_249900 Toxoplasma gondii Essentiality uncertain sidik
TGME49_300360 Toxoplasma gondii Essentiality uncertain sidik
TGME49_237700 Toxoplasma gondii Probably essential sidik
TGME49_249900 Toxoplasma gondii Probably essential sidik
TGME49_300360 Toxoplasma gondii Probably essential sidik
TGME49_237700 Toxoplasma gondii Probably non-essential sidik
TGME49_249900 Toxoplasma gondii Probably non-essential sidik
TGME49_300360 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 25 (mitochondrial carrier Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_18515 (Brugia malayi), ADP,ATP carrier protein, heart/skeletal muscle isoform T1
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