pI: 8.756 |
Length (AA): 234 |
MW (Da): 26313 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 234 | 3l5k (A) | 1 | 228 | 41.00 | 0 | 1 | 1.5725 | -1.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127060)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G25840 | glycerol-3-phosphatase 1 |
Arabidopsis thaliana | AT5G57440 | haloacid dehalogenase-like hydrolase family protein |
Brugia malayi | Bm1_20565 | haloacid dehalogenase-like hydrolase family protein |
Brugia malayi | Bm1_29890 | haloacid dehalogenase-like hydrolase family protein |
Brugia malayi | Bm1_29935 | HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein |
Brugia malayi | Bm1_29940 | haloacid dehalogenase-like hydrolase family protein |
Drosophila melanogaster | Dmel_CG31924 | CG31924 gene product from transcript CG31924-RB |
Drosophila melanogaster | Dmel_CG5565 | CG5565 gene product from transcript CG5565-RA |
Drosophila melanogaster | Dmel_CG15441 | GS1-like |
Escherichia coli | b1317 | beta-phosphoglucomutase |
Escherichia coli | b1727 | 2-deoxyglucose-6-P phosphatase |
Escherichia coli | b2690 | fructose-1-P and 6-phosphogluconate phosphatase |
Echinococcus granulosus | EgrG_000795350 | HAD superfamily hydrolase |
Echinococcus granulosus | EgrG_001188500 | haloacid dehalogenase hydrolase |
Entamoeba histolytica | EHI_074120 | HAD hydrolase, family IA, variant 3 |
Entamoeba histolytica | EHI_178660 | HAD hydrolase, family IA, variant 3 |
Entamoeba histolytica | EHI_088460 | HAD hydrolase, family IA, variant 3 |
Echinococcus multilocularis | EmuJ_001188500 | haloacid dehalogenase hydrolase |
Echinococcus multilocularis | EmuJ_000795350 | HAD superfamily hydrolase |
Giardia lamblia | GL50803_12220 | Hydrolase, putative |
Giardia lamblia | GL50803_14038 | Hydrolase, haloacid dehalogenase-like family |
Homo sapiens | ENSG00000130021 | haloacid dehalogenase-like hydrolase domain containing 1 |
Loa Loa (eye worm) | LOAG_13018 | HAD-superfamily hydrolase |
Loa Loa (eye worm) | LOAG_11165 | haloacid dehalogenase-like hydrolase |
Loa Loa (eye worm) | LOAG_06087 | HAD-superfamily hydrolase |
Loa Loa (eye worm) | LOAG_06086 | haloacid dehalogenase-like hydrolase |
Loa Loa (eye worm) | LOAG_10378 | HAD-superfamily hydrolase |
Mus musculus | ENSMUSG00000048875 | haloacid dehalogenase-like hydrolase domain containing 1A |
Oryza sativa | 4345048 | Os08g0243600 |
Saccharomyces cerevisiae | YKL033W-A | hypothetical protein |
Schistosoma japonicum | Sjp_0003310 | ko:K01915 glutamine synthetase [EC6.3.1.2], putative |
Schistosoma mansoni | Smp_042390 | 2-deoxyglucose-6-phosphate phosphatase |
Schmidtea mediterranea | mk4.063706.00 | |
Schmidtea mediterranea | mk4.000461.09 | Pseudouridine-5'-monophosphatase |
Schmidtea mediterranea | mk4.003452.03 | Pseudouridine-5'-monophosphatase |
Schmidtea mediterranea | mk4.049863.01 | |
Schmidtea mediterranea | mk4.000412.07 | Pseudouridine-5'-monophosphatase |
Trichomonas vaginalis | TVAG_117360 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_481930 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_398770 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_440810 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_417190 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_005730 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_430570 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_133450 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_007160 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_145590 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_133950 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_110720 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_023520 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_372950 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_547260 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_488000 | 2-deoxyglucose-6-phosphate phosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1317 | Escherichia coli | non-essential | goodall |
b1727 | Escherichia coli | non-essential | goodall |
b2690 | Escherichia coli | non-essential | goodall |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.