Detailed view for Bm1_01370

Basic information

TDR Targets ID: 236562
Brugia malayi, alpha-1,3-mannosyltransferase
Source Database / ID:  GenBank

pI: 7.1513 | Length (AA): 289 | MW (Da): 33359 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00534   Glycosyl transferases group 1
PF13439   Glycosyltransferase Family 4

Gene Ontology

Mouse over links to read term descriptions.
GO:0009058   biosynthetic process  

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 287 2jjm (A) 3 260 11.00 0.62 0.75 0.87038 1.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128575)

Species Accession Gene Product
Arabidopsis thaliana AT1G78800   glycosyltransferase domain-containing protein
Brugia malayi Bm1_01370   alpha-1,3-mannosyltransferase
Candida albicans CaO19.8808   similar to endoplasmic reticulum mannosyltransferase
Candida albicans CaO19.1221   similar to endoplasmic reticulum mannosyltransferase
Caenorhabditis elegans CELE_F09E5.2   Protein F09E5.2
Cryptosporidium hominis Chro.10033   ENSANGP00000013950
Cryptosporidium parvum cgd1_230   ALG-2 like alpha-1,3 mannosyltransferase
Dictyostelium discoideum DDB_G0272730   hypothetical protein
Drosophila melanogaster Dmel_CG1291   CG1291 gene product from transcript CG1291-RA
Echinococcus granulosus EgrG_001038800   alg protein
Entamoeba histolytica EHI_001990   alpha-1,3-mannosyltransferase ALG2, putative
Entamoeba histolytica EHI_162230   alpha-1,3-mannosyltransferase ALG2, putative
Echinococcus multilocularis EmuJ_001038800   alg protein ahpc tsa protein
Homo sapiens 85365   ALG2, alpha-1,3/1,6-mannosyltransferase
Leishmania braziliensis LbrM.20.1920   dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative
Leishmania donovani LdBPK_342190.1   glycosyltransferase-like protein
Leishmania infantum LinJ.34.2190   dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative
Leishmania major LmjF.34.2420   dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative
Leishmania mexicana LmxM.33.2420   glycosyltransferase-like protein
Loa Loa (eye worm) LOAG_01337   alpha-1,3-mannosyltransferase
Mus musculus ENSMUSG00000039740   asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)
Neospora caninum NCLIV_045600   glycosyl transferase, group 1 domain containing protein, putative
Oryza sativa 4336813   Os04g0589600
Saccharomyces cerevisiae YGL065C   GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
Schistosoma mansoni Smp_177080   alpha-1,3-mannosyltransferase
Schmidtea mediterranea mk4.001297.03   Alpha-1,3/1,6-mannosyltransferase ALG2
Trypanosoma brucei gambiense Tbg972.4.2190   glycosyltransferase ALG2, putative
Trypanosoma brucei Tb927.4.2230   dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative
Trypanosoma congolense TcIL3000_4_2020   glycosyltransferase ALG2, putative
Trypanosoma cruzi TcCLB.506559.420   dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative
Toxoplasma gondii TGME49_227790   glycosyltransferase, group 1 family protein
Trichomonas vaginalis TVAG_372200   alpha-1,3-mannosyltransferase, putative

Essentiality

Bm1_01370 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.2230 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.2230 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.2230 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.2230 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F09E5.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F09E5.2 Caenorhabditis elegans larval arrest wormbase
CELE_F09E5.2 Caenorhabditis elegans slow growth wormbase
YGL065C Saccharomyces cerevisiae inviable yeastgenome
TGME49_227790 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_01370 (Brugia malayi), alpha-1,3-mannosyltransferase
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