Detailed view for Bm1_28760

Basic information

TDR Targets ID: 237200
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 10.7125 | Length (AA): 62 | MW (Da): 7097 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 61 1wgg (A) 9 73 54.00 0.000000000025 1 1.49201 -0.1
4 44 2kx3 (A) 5 46 46.00 0.00011 0.74 1.17879 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127806)

Species Accession Gene Product
Arabidopsis thaliana AT1G51710   ubiquitin carboxyl-terminal hydrolase 6
Arabidopsis thaliana AT3G21280   ubiquitin-specific protease 7
Babesia bovis BBOV_III008630   ubiquitin carboxyl-terminal hydrolase family protein
Brugia malayi Bm1_28765   ubiquitin specific protease 14
Brugia malayi Bm1_56885   Ubiquitin carboxyl-terminal hydrolase family protein
Brugia malayi Bm1_28760   hypothetical protein
Candida albicans CaO19.6063   ubiquitin-specific protease
Candida albicans CaO19.13484   ubiquitin-specific protease
Caenorhabditis elegans CELE_C13B4.2   Protein USP-14
Cryptosporidium hominis Chro.10040   tRNA-guaninine transglycosylase
Cryptosporidium parvum cgd1_290   Ub6p like ubiquitin at N-terminus and ubiquitin C terminal hydrolase at the C-terminus
Dictyostelium discoideum DDB_G0271264   peptidase C19 family protein
Drosophila melanogaster Dmel_CG5384   CG5384 gene product from transcript CG5384-RB
Echinococcus granulosus EgrG_000580300   ubiquitin carboxyl terminal hydrolase 14
Echinococcus multilocularis EmuJ_000580300   ubiquitin carboxyl terminal hydrolase 14
Giardia lamblia GL50803_8189   Ubiquitin carboxyl-terminal hydrolase 14
Homo sapiens 9097   ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Leishmania braziliensis LbrM.31.0140   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania donovani LdBPK_310150.1   ubiquitin carboxyl-terminal hydrolase, putative
Leishmania infantum LinJ.31.0150   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania major LmjF.31.0140   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania mexicana LmxM.30.0140   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Loa Loa (eye worm) LOAG_02396   hypothetical protein
Loa Loa (eye worm) LOAG_02397   hypothetical protein
Mus musculus ENSMUSG00000047879   ubiquitin specific peptidase 14
Neospora caninum NCLIV_055070   Ubiquitin carboxyl-terminal hydrolase (EC 3.1.2.15), related
Oryza sativa 4326194   Os01g0550100
Plasmodium berghei PBANKA_1242000   ubiquitin carboxyl-terminal hydrolase 14, putative
Plasmodium falciparum PF3D7_0527200   ubiquitin carboxyl-terminal hydrolase 14
Plasmodium knowlesi PKNH_1005500   ubiquitin carboxyl-terminal hydrolase 14, putative
Plasmodium vivax PVX_079880   ubiquitin carboxyl-terminal hydrolase, putative
Plasmodium yoelii PY03738   tRNA-guaninine transglycosylase, putative, putative
Saccharomyces cerevisiae YFR010W   Ubp6p
Schistosoma japonicum Sjp_0209980   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma japonicum Sjp_0209970   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma mansoni Smp_084740   ubiquitin-specific peptidase 14 (C19 family)
Schmidtea mediterranea mk4.009566.00   Ubiquitin carboxyl-terminal hydrolase 14
Trypanosoma brucei gambiense Tbg972.4.3850   ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Trypanosoma brucei Tb927.4.3790   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma congolense TcIL3000_0_29070   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma congolense TcIL3000_4_3320   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma congolense TcIL3000_0_32960   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma cruzi TcCLB.504443.10   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma cruzi TcCLB.506569.10   ubiquitin carboxyl-terminal hydrolase, putative
Toxoplasma gondii TGME49_311090   ubiquitin carboxyl-terminal hydrolase
Theileria parva TP04_0767   ubiquitin carboxyl-terminal hydrolase, putative
Trichomonas vaginalis TVAG_296140   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase

Essentiality

Bm1_28760 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.3790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.3790 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.3790 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.3790 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1242000 Plasmodium berghei Dispensable plasmo
TGME49_311090 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) Compounds References
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_28760 (Brugia malayi), hypothetical protein
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