Detailed view for Bm1_13930

Basic information

TDR Targets ID: 237209
Brugia malayi, Low-density lipoprotein receptor-related protein, putative
Source Database / ID:  GenBank

pI: 4.7938 | Length (AA): 4043 | MW (Da): 451705 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00057   Low-density lipoprotein receptor domain class A
PF00058   Low-density lipoprotein receptor repeat class B

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005515   protein binding  
GO:0005509   calcium ion binding  

Metabolic Pathways

Hedgehog signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 23 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 76 2gtl (O) 35 101 34.00 0.012 0.19 0.37803 -0.5
17 75 2fcw (B) 106 163 29.00 0.19 0.08 0.296593 -0.61
35 78 1j8e (A) 1 44 41.00 0.07 0.25 0.503883 -1.25
38 73 1cr8 (A) 5 41 56.00 0.000016 0.73 0.697104 -0.82
210 246 2jm4 (A) 6 43 46.00 0.0088 0.88 0.578352 -0.48
250 354 4d90 (A) 26 148 36.00 0.36 0.99 0.0121708 0.76
1049 1763 1n7d (A) 49 693 36.00 0 1 0.242049 1.88
1155 1232 5b4y (B) 46 121 50.00 0 0.95 0.621493 -0.34
1155 1194 2m0p (A) 1109 1146 61.00 0.00000026 0.7 0.698094 -0.65
1195 1232 1j8e (A) 4 41 61.00 0.00000012 0.95 0.835599 -1.28
1419 1451 1szb (A) 133 165 45.00 0.24 0.99 0.624362 -0.74
1462 2103 4dg6 (A) 5 616 33.00 0 1 0.499993 0.12
1487 2088 4a0p (A) 661 1236 31.00 0 1 0.494099 -0.12
1491 1712 1npe (A) 951 1169 34.00 0 1 0.55211 -0.84
1766 2408 4a0p (A) 632 1243 21.00 0 1 0.32304 0.09
1815 2050 1npe (A) 950 1175 21.00 0.0000000019 1 0.281372 -0.2
1818 2408 4dg6 (A) 37 608 25.00 0 1 0.340179 0.49
2965 3041 2xrc (A) 209 272 58.00 0.0000000034 1 0.472245 0.2
3052 3086 1d2l (A) 5 39 69.00 0.000000062 0.96 0.806857 -0.19
3093 3127 3a7q (B) 47 81 54.00 0.0000081 0.86 0.765857 -1.38
3656 4027 3v65 (D) 358 729 20.00 0 1 0.279011 0.36
3856 3969 3saq (A) 312 430 30.00 0.9 0.15 0.0163969 1
3992 4040 1aut (L) 91 138 21.00 0.5 0.14 0.16112 -0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126933)

Species Accession Gene Product
Brugia malayi Bm1_38925   Low-density lipoprotein receptor repeat class B containing protein
Brugia malayi Bm1_13930   Low-density lipoprotein receptor-related protein, putative
Caenorhabditis elegans CELE_T21E3.3   Protein LRP-2
Caenorhabditis elegans CELE_F29D11.1   Protein LRP-1
Drosophila melanogaster Dmel_CG33087   LDL receptor protein 1
Drosophila melanogaster Dmel_CG5912   arrow
Drosophila melanogaster Dmel_CG1372   yolkless
Drosophila melanogaster Dmel_CG42611   Megalin
Drosophila melanogaster Dmel_CG8909   CG8909 gene product from transcript CG8909-RC
Echinococcus granulosus EgrG_000813700   low density lipoprotein receptor protein
Echinococcus multilocularis EmuJ_000813700   low density lipoprotein receptor protein
Homo sapiens ENSG00000123384   low density lipoprotein receptor-related protein 1
Homo sapiens ENSG00000168702   low density lipoprotein receptor-related protein 1B
Homo sapiens ENSG00000070018   low density lipoprotein receptor-related protein 6
Homo sapiens 102724336   low-density lipoprotein receptor-related protein 5-like
Homo sapiens ENSG00000081479   low density lipoprotein receptor-related protein 2
Homo sapiens ENSG00000134569   low density lipoprotein receptor-related protein 4
Homo sapiens ENSG00000162337   low density lipoprotein receptor-related protein 5
Loa Loa (eye worm) LOAG_09477   hypothetical protein
Loa Loa (eye worm) LOAG_02273   hypothetical protein
Loa Loa (eye worm) LOAG_13684   hypothetical protein
Loa Loa (eye worm) LOAG_02628   low-density lipoprotein receptor repeat class B containing protein
Mus musculus ENSMUSG00000030201   low density lipoprotein receptor-related protein 6
Mus musculus 102638246   predicted gene, 34855
Mus musculus ENSMUSG00000040249   low density lipoprotein receptor-related protein 1
Mus musculus ENSMUSG00000049252   low density lipoprotein-related protein 1B (deleted in tumors)
Mus musculus 102642234   low-density lipoprotein receptor-related protein 6-like
Mus musculus ENSMUSG00000027070   low density lipoprotein receptor-related protein 2
Mus musculus ENSMUSG00000027253   low density lipoprotein receptor-related protein 4
Mus musculus ENSMUSG00000024913   low density lipoprotein receptor-related protein 5
Onchocerca volvulus OVOC4862   Arrow homolog
Plasmodium yoelii PY05967   MSP4/5-related
Schmidtea mediterranea mk4.003192.01  
Schmidtea mediterranea mk4.018153.01  
Schmidtea mediterranea mk4.025579.01  
Schmidtea mediterranea mk4.000386.24  
Schmidtea mediterranea mk4.025579.00   LpR2
Schmidtea mediterranea mk4.000328.15  
Schmidtea mediterranea mk4.005080.01  

Essentiality

Bm1_13930 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F29D11.1 Caenorhabditis elegans larval arrest wormbase
CELE_F29D11.1 Caenorhabditis elegans larval lethal wormbase
CELE_F29D11.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens low density lipoprotein receptor-related protein 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0005 0.5 0.5
0.0006 0.5 0.5
0.0089 0.4346 0.4346
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0063 0.5623 0.508
0.0006 1 1
0.0006 0.5 0.5
0.0114 0.5665 0.5665
0.0006 0.5 0.5
0.0012 0.5 0.5
0.0006 1 1
0.0005 1 1
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0025 0.277 0.277
0.0012 0.5 0.5
0.0006 1 1
0.0012 0.5 0.5
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0163 0.3454 0.3631
0.0006 0.5 0.5
0.0103 0.9438 0.9438
0.0005 1 1
0.0012 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_13930 (Brugia malayi), Low-density lipoprotein receptor-related protein, putative
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