Detailed view for Bm1_42480

Basic information

TDR Targets ID: 237410
Brugia malayi, glutamate-cysteine ligase modifier subunit
Source Database / ID:  GenBank

pI: 6.0802 | Length (AA): 281 | MW (Da): 32415 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00248   Aldo/keto reductase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0035226   glutamate-cysteine ligase catalytic subunit binding  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0006750   glutathione biosynthetic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 268 4q3m (A) 3 227 24.00 0.007 1 1.06866 -0.24
24 268 2bgs (A) 18 256 18.00 0 0.83 1.11279 -0.41
85 225 3h7u (A) 71 207 23.00 0.037 1 0.882879 -0.99
85 221 3b3d (A) 73 190 26.00 0.02 1 0.783644 -1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132636)

Species Accession Gene Product
Brugia malayi Bm1_42480   glutamate-cysteine ligase modifier subunit
Caenorhabditis elegans CELE_E01A2.1   Protein E01A2.1, isoform A
Drosophila melanogaster Dmel_CG4919   Glutamate-cysteine ligase modifier subunit
Echinococcus granulosus EgrG_000887650   glutamate cysteine ligase regulatory
Echinococcus multilocularis EmuJ_000887650  
Loa Loa (eye worm) LOAG_04160   glutamate-cysteine ligase modifier subunit
Mus musculus 14630   glutamate-cysteine ligase, modifier subunit
Onchocerca volvulus OVOC10346  
Schmidtea mediterranea mk4.025592.00  
Schmidtea mediterranea mk4.050649.00  
Schmidtea mediterranea mk4.002098.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0191 0.36 1
0.0349 0.4052 0.9331
0.0098 0.2533 0.2533
0.0581 0.2871 0.2871
0.0009 0.5 0.5
0.0091 0.2585 0.2585
0.0435 0.2838 0.2833
0.0268 0.2557 0.2851
0.028 0.2827 0.2827
0.0098 0.2533 0.2533
0.0211 0.374 1
0.0377 0.2702 0.2694
0.0222 0.2579 0.2734
0.0486 0.2879 0.2853
0.0284 0.2848 0.2848
0.0408 0.2849 0.2849
0.0267 0.2614 0.2857
0.0313 0.3557 1
0.0369 0.9928 1
0.0161 0.2836 0.2836
0.0199063 0.279562 0.279562
0.0291 0.259 0.259
0.0124 1 1
0.076 0.2768 0.2768
0.004 0.5148 0.8926
0.0151 1 1
0.0111 0.2633 0.2685
0.0162 0.2676 0.2671
0.0059 0.2961 0.2961
0.0179 0.2537 0.2537
0.0099 0.2571 0.2571
0.0076 0.2667 0.2667
0.0262 0.2844 0.9053
0.0222 0.2773 0.2745
0.0167 0.2773 0.2822
0.0219 0.778 1
0.0764 0.2875 0.2875
0.0064 0.9545 0.9545
0.0177 0.2579 0.2579
0.0095 1 1
0.0764 0.2875 0.2875
0.0028 0.5 0.5
0.0269 0.2748 0.2748
0.0295 0.3658 1
0.0242 0.2855 0.2855
0.0202 1 1
0.043 0.2876 0.2865
0.0326 0.2809 0.277
0.0269 0.2748 0.2748
0.0775 0.2848 0.2848
0.0301 0.3144 1
0.0342 0.365 1
0.0217 0.2779 0.2777
0.0285 0.284 0.284
0.0269 0.2546 0.26
0.0083 0.2705 0.2608
0.0216 0.2638 0.2848
0.0157 0.2735 0.2391
0.0139 0.2565 0.2565
0.0259 0.2625 0.3072
0.0108 0.2793 0.2793
0.0011 0.5 0.5
0.0098 0.2597 0.2597
0.0095 1 1
0.0349 0.4052 0.9331
0.0065 0.5 0.5
0.03 0.2576 0.2576
0.0775 0.2848 0.2848
0.0419 0.2848 0.2848
0.0248 0.2861 0.2853
0.0104 0.2511 0.2511
0.0175 0.2828 0.2828
0.0064 0.2576 0.2576
0.0143 0.2973 0.308
0.0178 0.2529 0.2529
0.026 0.2829 0.2855
0.0132 0.7333 1
0.0362 0.378 1
0.0404 0.2668 0.2668
0.0166 0.2605 0.2605
0.029 0.6621 1
0.0447 0.2831 0.2831
0.0141 0.2608 0.2608
0.0405 0.2825 0.2825
0.0397 1 1
0.0137 0.2732 0.2732
0.0009 0.5 0.5
0.0728 0.281 0.2377
0.0261 0.2776 0.2776
0.0691 0.2763 0.2753
0.0327 0.3271 0.6039
0.0149 0.7154 1
0.0262 0.279 0.279
0.012 0.2736 0.2736
0.072 0.2794 0.2794
0.0289 0.3315 1
0.0075 0.2553 0.2553
0.0803 0.2819 0.2819
0.0222 0.3677 1
0.0099 0.2571 0.2571
0.0385 0.2793 0.2793
0.0037 0.5707 1
0.0124 0.2557 0.2451
0.0287 0.252 0.252
0.015 0.2553 0.2553
0.029 0.284 0.2827
0.0689 0.2821 0.28
0.0097 0.266 0.266
0.0278 0.284 0.284
0.0418 0.2865 0.2865
0.0259 0.8384 0.8365
0.0681 0.284 0.284
0.0192 0.701 0.701
0.0288 0.2888 0.5311
0.0227 0.8574 0.8574
0.0126 0.3266 0.6261
0.0279 0.2841 0.2828
0.0189 0.3641 1
0.0113 0.2622 0.2622
0.0644 0.2872 0.2871
0.0224 0.2838 0.2838
0.0166 0.2821 0.2744
0.0018 1 1
0.0277 0.2855 0.2851
0.0216 0.2688 0.2841
0.0976 0.2871 0.2871
0.0414 0.2849 0.2754
0.0097 0.2578 0.2578
0.0228 0.2784 0.2783
0.0314 0.3709 1
0.0222 0.2773 0.2745
0.0356 0.2868 0.2868
0.0093 0.289 0.289
0.0212 0.3525 1
0.0011 0.5 0.5
0.0711 0.2866 0.2866
0.0142 0.4288 0.4271
0.0095 0.2694 0.2694
0.0037 0.2705 0.2705
0.0644 0.2872 0.2871
0.0068 0.2586 0.2586
0.0188 0.2582 0.5
0.0124 0.2557 0.2451
0.0349 0.4052 0.9331
0.0113 1 1
0.0251 0.2569 0.2569
0.0228 0.2784 0.2783
0.0419 0.2848 0.2848
0.0345 0.2767 0.2712
0.0210423 0.286758 0.286758
0.0728 0.281 0.2377
0.019 0.3172 1
0.0369 0.9928 1
0.0711 0.2866 0.2866
0.0134 0.2657 0.2657
0.0176 0.2759 0.2759
0.0111 0.262 0.2734
0.022 0.2585 0.2547
0.0161 0.2836 0.2836
0.0417 0.2648 0.2648
0.0277 0.9974 1
0.0183 0.2837 0.2837
0.0644 0.2872 0.2871
0.0218 0.3757 1
0.0228 0.2784 0.2783
0.0803 0.2819 0.2819
0.0137 0.2732 0.2732
0.0049 0.7607 1
0.0296 0.2862 0.2839
0.0422 0.2817 0.2802
0.0313 0.287 0.2864
0.0092 0.2686 0.2686
0.0333 0.286 0.286
0.0263 0.2656 0.2656
0.0245 0.7634 0.7633
0.0219 0.2804 0.2804
0.0343 0.3796 1
0.0681 0.284 0.284
0.0105 0.2699 0.2699
0.0212 0.2526 0.2781
0.021 0.2782 0.2755
0.0124 0.2557 0.2451
0.0009 1 1
0.0764 0.2875 0.2875
0.0086 0.2573 0.2573
0.0047 0.254 0.254
0.0728 0.281 0.2377
0.013 0.252 0.2494
0.0266 0.2858 0.2856
0.0099 0.2701 0.2701
0.0122 0.2828 0.2749
0.0188 0.3403 0.5615
0.0249 0.2734 0.2706
0.0273 0.284 0.2827
0.076 0.2768 0.2768
0.0267 0.4685 0.917
0.0291 1 1
0.0104 0.2731 0.3172
0.0133 0.347 0.5176
0.0136 0.2596 0.2596
0.0147 0.2791 0.2791
0.0038 0.2659 0.2267
0.0358 1 1
0.0248 0.2657 0.2657
0.0302 0.3521 1
0.0232 0.2744 0.2744
0.0066 0.2599 0.2599
0.0293 0.255 0.254
0.0728 0.281 0.2377
0.0447 0.2831 0.2831
0.0792 0.2864 0.2862
0.0103 0.5227 0.5227
0.0403 1 1
0.005 0.2563 0.2409
0.0486 0.2879 0.2853
0.0447 0.2831 0.2831
0.0323 1 1
0.0048 1 1
0.0128 0.5 0.5
0.003 0.2645 0.2229
0.0116 0.2503 0.2503
0.0486 0.2879 0.2853
0.0107 0.2693 0.2693
0.0011 0.5 0.5
0.015 0.4976 0.4976
0.0028 0.5 0.5
0.0210423 0.286758 0.286758
0.0406 0.285 0.285
0.0265 0.2698 0.2655
0.0244 0.2658 0.1963
0.0429 0.2846 0.2846
0.028 0.2738 0.978
0.0066 0.2599 0.2599
0.0704 0.2637 0
0.0719 0.2869 0.2869
0.0728 0.2627 0.2855
0.0412 0.2751 0.2751
0.0122 0.2815 0.2815
0.0208 0.2751 0.2751
0.0723 0.2873 0.2873
0.0193 0.2745 0.2745
0.0226 0.2613 0.7666
0.0203 0.6548 0.8024
0.0124 0.2557 0.2451
0.0325 0.8695 1
0.0083 0.5859 0.568
0.0267 0.4685 0.917
0.000559795 0.5 0.5
0.0258 0.2864 0.2853
0.0266 0.28 0.2798
0.0283 0.3077 1
0.0358 1 1
0.0259 0.2625 0.3072
0.0248 0.2861 0.2853
0.0224 0.2774 0.2773
0.0162 0.2676 0.2671
0.0187 0.2619 0.2648
0.0308 0.3052 1
0.0078 0.2628 0.2628
0.0379 0.3762 1
0.0486 0.2879 0.2853
0.0317 0.2864 0.2864
0.0187 0.2763 0.2761
0.0249 0.2734 0.2706
0.0728 0.2627 0.2855
0.038 0.2765 0.2765
0.0362 0.2852 0.2824
0.0215 0.3858 1
0.0142 0.4288 0.4271
0.0189 0.2829 0.2829
0.0241 0.2757 0.2747
0.0219 0.2804 0.2804
0.0029 0.5 0.5
0.0169 0.2516 0.2847
0.0334 0.3608 1
0.0283 0.325 0.9887
0.0775 0.2848 0.2848
0.0123 0.2743 0.2743
0.0098 0.2938 0.2938
0.0775 0.2848 0.2848
0.0441827 0.31328 0.312806
0.0321 0.383 1
0.0228 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_42480 (Brugia malayi), glutamate-cysteine ligase modifier subunit
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