Detailed view for Bm1_03415

Basic information

TDR Targets ID: 238259
Brugia malayi, protein-tyrosine phosphatase Lar-like precursor, putative
Source Database / ID:  GenBank

pI: 7.5092 | Length (AA): 250 | MW (Da): 27814 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 247 4yh7 (A) 375 611 40.00 0 1 1.3377 0.91
10 247 4pbx (A) 364 600 38.00 0 1 1.4037 0.01
55 96 2n1k (A) 8 45 47.00 0.19 0.39 0.5127 0.57
57 155 4n68 (A) 875 971 28.00 0.0000079 1 0.8747 -1.26
59 153 4wtx (A) 1572 1665 28.00 0 0.8 0.8394 -1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_171256)

Species Accession Gene Product
Brugia malayi Bm1_03415   protein-tyrosine phosphatase Lar-like precursor, putative
Schistosoma japonicum Sjp_0115140   Tyrosine-protein phosphatase Lar precursor, putative
Schistosoma japonicum Sjp_0082670   Receptor-type tyrosine-protein phosphatase delta precursor, putative
Schistosoma japonicum Sjp_0082660   IPR003961,Fibronectin, type III;IPR008957,Fibronectin, type III-like fold,domain-containing
Schistosoma japonicum Sjp_0109650   hypothetical protein
Schistosoma japonicum Sjp_0098880   Receptor-type tyrosine-protein phosphatase delta precursor, putative
Schistosoma japonicum Sjp_0115130   IPR013098,Immunoglobulin I-set;IPR007110,Immunoglobulin-like,domain-containing
Schistosoma japonicum Sjp_0112330   Tyrosine-protein phosphatase Lar precursor, putative
Schistosoma mansoni Smp_134190   cell adhesion molecule
Schistosoma mansoni Smp_130560   cell adhesion molecule
Schmidtea mediterranea mk4.012532.01  
Schmidtea mediterranea mk4.016597.00  
Schmidtea mediterranea mk4.010669.01  
Schmidtea mediterranea mk4.019891.00  
Schmidtea mediterranea mk4.006791.00  
Schmidtea mediterranea mk4.019891.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0142 0.2992 0.3965
0.0334 0.4633 0.6876
0.0009 0.5 0.5
0.0475 0.706 1
0.0016 1 1
0.0461 0.2819 0.999
0.0039 0.3299 0.4024
0.0116 0.6967 0.9164
0.0448 0.7636 1
0.0251 0.7407 1
0.0446 0.3014 0.2972
0.0446 0.3014 0.2972
0.0178 0.5983 0.5
0.0155 0.3568 1
0.0338 0.7566 1
0.0271 0.3613 1
0.0336 0.3462 1
0.0446 0.3014 0.2972
0.0216 0.706 1
0.0132 0.2972 0.4456
0.0167 0.3197 0.4301
0.02 0.7068 1
0.0251 0.7407 1
0.0313 0.5953 1
0.037 0.706 1
0.0471 0.341 1
0.0165 0.3513 0.4712
0.0275 0.301 0.4695
0.0089 0.4623 0.4623
0.022 0.257 0.5218
0.0111 0.334 0.3848
0.0115 0.2557 0.3611
0.0129 0.3276 0.8182
0.0414 0.6115 1
0.0461 0.2819 0.999
0.0084 0.6788 1
0.017 0.2614 1
0.0343 0.706 1
0.0104 0.8804 0.8804
0.0085 0.3268 0.4093
0.0461 0.2819 0.999
0.0255 0.706 1
0.012 0.7362 0.9962
0.0446 0.3014 0.2972
0.0156 0.6042 1
0.0414 0.6115 1
0.0378 0.586 1
0.0048 0.4176 0.4167
0.0334 0.4633 0.6876
0.022 0.257 0.5218
0.0275 0.301 0.4695
0.008 0.4641 0
0.0261 0.3873 0.5021
0.0378 0.586 1
0.0223 0.4639 0
0.0075 0.4317 0.4742
0.0255 0.706 1
0.0255 0.2557 0.3611
0.0343 0.706 1
0.0275 0.301 0.4695
0.0156 0.6042 1
0.0241 0.3986 0.5216
0.0471 0.341 1
0.0261 0.2557 0.3611
0.0164 0.7647 0.7789
0.0114 0.6153 1
0.0403 0.706 1
0.0184 0.706 1
0.043 0.5151 1
0.0275 0.301 0.4695
0.0446 0.3014 0.2972
0.0266 0.2855 1
0.0374 0.7576 1
0.0488 0.3798 1
0.0344 0.6972 0.8423
0.0089 0.442 0.3902
0.0165 0.3513 0.4712
0.0351 0.6072 1
0.0084 0.6788 1
0.0241 0.3619 0.4827
0.0178 0.5983 0.5
0.0275 0.301 0.4695
0.0167 0.3197 0.4301
0.0153 0.3082 0.4077
0.0446 0.3014 0.2972
0.0223 0.4639 0
0.0461 0.2819 0.999
0.0034 0.2581 0.2581
0.0446 0.3014 0.2972
0.0272 0.706 1
0.0446 0.3014 0.2972
0.012 0.7362 0.9962
0.0083 1 1
0.0312 0.5397 1
0.0258 0.3891 0.5117
0.0048 0.432 0.432
0.0089 0.442 0.3902
0.0216 0.3372 0.4556
0.0374 0.7576 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_03415 (Brugia malayi), protein-tyrosine phosphatase Lar-like precursor, putative
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