Detailed view for Bm1_28740

Basic information

TDR Targets ID: 239072
Brugia malayi, cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmcyp-15

Source Database / ID: GenBank / Bm1_28740

pI: 7.1682 | Length (AA): 628 | MW (Da): 71216 | Number of Paralogs: 0

EC number(s): 5.2.1.8 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: ND

Pfam domains

PF00400   WD40

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Bm1_28740  

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 25
Cumulative epitope score: 27.9
Normalized epitope score: 4.4
Percentile: 47.9 (this protein belongs to the top 52.1% proteins in the genome of Brugia malayi, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_11783
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_190046   CYP71 (CYCLOPHILIN71); chromatin binding / histone binding ... |   OrthoMCL
Babesia bovis XP_001610877.1   peptidyl-prolyl cis-trans isomerase ... |   OrthoMCL
Brugia malayi Bm1_28740 (this record).   cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmc... |   OrthoMCL
Caenorhabditis elegans Y87G2A.6   CE24686 WBGene00000891 locus:cyn-15 cyclophilin status:Parti... |   OrthoMCL
Cryptosporidium hominis Chro.70067   protein-related ... |   OrthoMCL
Cryptosporidium muris CMU_006350   peptidyl-prolyl cis-trans isomerase, cyclophilin-type famil... |   OrthoMCL
Cryptosporidium neoformas XP_568847   peptidyl-prolyl cis-trans isomerase ... |   OrthoMCL
Cryptosporidium parvum cgd7_520   cyclincyclophilin like peptidyl-prolyl cis-trans isomerase ... |   OrthoMCL
Drosophila melanogaster FBpp0072216   |   OrthoMCL
Escherichia coli K12 NP_415058.1   peptidyl-prolyl cis-trans isomerase B (rotamase B) [Escheric... |   OrthoMCL
Homo sapiens ENSP00000261308   |   OrthoMCL
Mycobacterium leprae strain TN ML0011   Probable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A)... |   OrthoMCL
Mus musculus ENSMUSP00000022226   |   OrthoMCL
Mycobacterium tuberculosis Rv0009   PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE ... |   OrthoMCL
Neospora caninum NCLIV_009630   |   OrthoMCL
Oryza sativa NP_001062485   Os08g0557500 ... |   OrthoMCL
Plasmodium berghei PB000833.02.0   cyclophilin, putative ... |   OrthoMCL
Plasmodium chabaudi PCAS_110950   cyclophilin, putative ... |   OrthoMCL
P. falciparum 3D7 PFE0505w   cyclophilin, putative... |   OrthoMCL
Plasmodium knowlesi PKH_102270   cyclophilin, putative ... |   OrthoMCL
Plasmodium vivax PVX_098070   cyclophilin, putative... |   OrthoMCL
Plasmodium yoelii PY03899   putative protein-related ... |   OrthoMCL
Schistosoma mansoni Smp_133820   peptidyl-prolyl cis-trans isomerase-like... |   OrthoMCL
Toxoplasma gondii TGME49_120640   cyclophilin, putative... |   OrthoMCL

Essentiality Bm1_28740 has essentiality data
Gene/Ortholog: mtu9 (OG4_11783); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco514 (OG4_11783); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco514 (OG4_11783); Phenotype: essential; Source study: gerdes
Gene/Ortholog: eco514 (OG4_11783); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco514 (OG4_11783); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

    Log in to add comments, or register.