Detailed view for Bm1_41455

Basic information

TDR Targets ID: 239764
Brugia malayi, NNMT/PNMT/TEMT family protein
Source Database / ID:  GenBank

pI: 5.9956 | Length (AA): 300 | MW (Da): 34355 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01234   NNMT/PNMT/TEMT family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  

Metabolic Pathways

Nicotinate and nicotinamide metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 298 2iip (A) 0 259 24.00 0 1 1.23487 -0.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132055)

Species Accession Gene Product
Brugia malayi Bm1_41455   NNMT/PNMT/TEMT family protein
Caenorhabditis elegans CELE_F42A10.3   Protein ANMT-2
Caenorhabditis elegans CELE_B0303.2   Protein ANMT-1
Caenorhabditis elegans CELE_T07C12.9   Protein ANMT-3
Homo sapiens ENSG00000241644   indolethylamine N-methyltransferase
Homo sapiens ENSG00000166741   nicotinamide N-methyltransferase
Loa Loa (eye worm) LOAG_12069   hypothetical protein
Loa Loa (eye worm) LOAG_01142   NNMT/PNMT/TEMT family protein
Loa Loa (eye worm) LOAG_14929   hypothetical protein
Mus musculus ENSMUSG00000032271   nicotinamide N-methyltransferase
Mus musculus ENSMUSG00000003477   indolethylamine N-methyltransferase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens indolethylamine N-methyltransferase Compounds References
Homo sapiens nicotinamide N-methyltransferase Compounds References
Oryctolagus cuniculus Indolethylamine N-methyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Phenylethanolamine N-methyltransferase 283 aa 26.0% 254 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1412 0.7863 1
0.3411 0.6895 1
0.0926 0.5543 0.6097
0.0913 0.6464 0.7068
0.0667 0.2705 0.3972
0.0897 0.6462 0.7063
0.0954 0.2505 0.55
0.0271 0.2881 1
0.0333 0.4452 0.463
0.3411 0.6895 1
0.0884 0.6478 0.7083
0.0954 0.555 0.6101
0.0333 0.4419 0.5032
0.0274 0.2957 0.2957
0.0705 0.4533 0.4533
0.0282 0.3807 0.4353
0.0846 0.6653 0
0.1365 0.8492 1
0.0896 0.6467 0.707
0.0269 0.7597 1
0.0986 0.5546 0.61
0.0267 0.6326 1
0.0269 0.363 1
0.1933 0.9826 0.9826
0.1416 0.3215 0.3215
0.0869 0.3799 0.3798
0.0708 0.318 0.4964
0.0921 0.645 0.7055
1.0728 0.3684 0.3684
0.0873 0.6465 0.7071
0.1093 0.3271 0.7563
0.0986 0.4256 0.6095
0.0333 0.2602 1
0.0871 0.3164 0.3164
0.0599 0.6306 1
0.0867 0.7849 0.8505
0.1399 0.9153 1
0.0869 0.3799 0.3798
0.3145 0.876 1
0.0982 0.553 0.6083
0.0333 0.6301 1
0.0956 0.4279 1
0.0873 0.6455 0.7056
0.0552 0.647 1
0.3411 0.6895 1
0.1502 0.5211 0.5211
0.0641 0.4816 0.7447
0.1951 0.5646 0.5644
0.0667 0.3501 0.4407
0.0275 0.402 1
0.0931 0.6269 1
0.0623 0.7016 1
0.3411 0.6895 1
0.0599 0.3237 1
0.0298 0.4233 1
0.0699 0.9471 1
0.0573 0.3419 1
0.0721 0.4457 1
0.0879 0.5505 0.6055
0.0869 0.3799 0.3798
0.0574 0.4074 1
0.0968 0.553 0.6083
0.3554 0.447 0.447
0.0923 0.2639 0.2636
0.0667 0.3878 0.5943
0.1587 0.5194 0.5192
0.0268 0.6566 1
0.0954 0.2505 0.55
0.0612 0.6229 1
0.0907 0.3633 0.3633
0.3788 0.3102 0.5875
0.0705 0.4533 0.4533
0.1132 0.8125 1
0.1421 0.9293 1
0.1445 0.3734 0.3732
0.0333 0.3019 0.2982
0.0162 0.3967 0.7922
0.2232 0.2512 0.9818
0.0333 0.7312 1
0.0556 0.6042 1
0.1416 0.3215 0.3215
0.1587 0.5194 0.5192
0.0333 0.3387 0
0.0333 0.3224 0.4464
0.0853 0.5979 1
0.1072 0.649 0.7104
0.1416 0.3215 0.3215
0.1006 0.5553 0.6106
0.0824 0.6389 0
0.0624 0.7449 1
0.1416 0.3215 0.3215
0.1001 0.5543 0.6097
0.0137 0.3758 0.4301
0.0667 0.9853 0.9853
0.0281 0.3674 0.6179
0.0912 0.3799 0.3796
0.1412 0.7863 1
0.0945 0.5554 0.6108
0.1727 0.2764 1
0.1512 0.5197 0.5192
0.2878 0.6217 0.6217
0.1727 0.2764 1
0.6939 0.2807 1
0.0268 0.2731 1
0.0521 0.4575 0.8579
0.0833 0.5054 1
0.1445 0.3757 0.3757
0.0987 0.5545 0.6096
0.0287 0.335 1
0.0275 0.5489 0.6286
0.0869 0.3799 0.3798
0.1363 0.6625 1
0.0986 0.4256 0.6095
0.0949 0.5542 0.6096
0.1416 0.3215 0.3215
0.1742 0.3999 0.3999
0.2828 0.4977 1
0.0547 0.7411 0.7411
0.0954 0.2505 0.55
0.0137 0.3758 0.4301
0.0276 0.939 1
0.1416 0.3215 0.3215
0.1017 0.554 0.591
0.0857 0.3998 0.3998
0.0554 0.694 0.9102
0.1416 0.3215 0.3215
0.0945 0.5541 0.609
0.029 0.3599 0.3599
0.1067 0.5558 0.611
0.17 0.484 0.484
0.0918 0.6462 0.7068
0.0309 0.5836 0.6701
0.1502 0.5203 0.5202
0.0333 0.3692 1
0.1119 0.3597 0.3597
0.0833 0.5054 1
0.2828 0.4977 1
0.0825 0.284 0.7838
0.0641 0.4816 0.7447
0.0267 0.3155 0.3143
0.0923 0.6471 0.7077
0.0274 0.2568 0.2913
0.0746 0.7687 1
0.0641 0.4816 0.7447
0.0282 0.3807 0.4353
0.2495 0.329 0.6329
0.031 0.4596 0.5632
0.0885 0.6479 0.7083
0.0333 0.3241 1
0.1662 0.52 0.5192
0.1429 0.3999 0.7211
0.0986 0.5536 0.6089
0.0913 0.647 0.7072
0.0667 0.3778 0.3778
0.0267 0.3367 1
0.1951 0.5646 0.5644
0.0989 0.5544 0.6095
0.0951 0.5544 0.6097
0.0945 0.554 0.6056
0.0923 0.2639 0.2636
0.418779 0.5 0.5
0.4061 0.5325 1
0.4821 0.305 1
0.0934 0.5502 0.6052
0.1676 0.475 0.475
0.0946 0.304 0.3037
0.0553 0.4394 1
0.1017 0.554 0.591
0.0294 0.3071 0.5172
0.804 0.5 1
0.0866 0.6065 1
0.0274 0.2957 0.2957
0.3317 0.7152 1
0.0333 0.2569 0.2569
0.0268 0.2961 0.7726
0.1505 0.4844 0.4844
0.0892 0.6458 0.7062
0.3045 0.2966 1
0.4821 0.305 1
0.062 0.7118 0.7118
0.0667 0.8956 0.8955
0.1416 0.3215 0.3215
0.1405 0.752 1
0.0994 0.5543 0.6097
0.3332 0.9471 1
0.0869 0.6478 0.7074
0.0886 0.6458 0.6687
0.0286 0.328 0.7022
0.0824 0.5449 0.5449
0.1727 0.2764 1
0.0961 0.5544 0.6092
0.0951 0.5554 0.6102
0.0954 0.555 0.6101
0.0866 0.3158 0.3154
0.0934 0.5544 0.6098
0.1399 0.9153 1
0.0746 0.8231 1
0.0872 0.6465 0.7066
0.0593 0.5607 1
0.0878 0.6427 0.7083
0.1416 0.3215 0.3215
0.0825 0.529 1
0.1662 0.52 0.5192
0.0667 0.2662 0.2662
0.3788 0.3103 0.5875
0.093 0.645 0.7056
0.2688 0.3293 0.694
0.1011 0.5547 0.6101
0.0878 0.6427 0.7083
0.0891 0.9062 1
0.1933 0.9826 0.9826
0.0889 0.6494 0.7094
0.1783 0.4454 1
0.1727 0.2764 1
0.0825 0.9888 1
0.1129 0.8318 1
0.0771 0.4239 0.4239
0.0986 0.5546 0.61
0.4821 0.305 1
0.0279 0.3002 1
0.0934 0.5544 0.6097
0.0267 0.5095 0.5008
0.0607179 1 1
0.0667 0.2705 0.2843
0.1119 0.3395 0.3395
0.0276 0.3285 1
0.0961 0.555 0.6103
0.1405 0.752 1
0.0667 0.2662 0.2662
0.4821 0.305 1
0.1405 0.752 1
0.0286 0.3825 1
0.1073 0.5558 0.611
0.0276 0.3337 1
0.0599 0.6308 1
0.0573 0.3419 1
0.0273 0.5277 1
0.1727 0.2764 1
0.0575 0.3918 1
0.1044 0.5544 0.6095
0.0567 0.4028 1
0.1067 0.5558 0.611
0.096 0.5543 0.6097
0.0954 0.2505 0.55
0.1026 0.5558 0.611
0.0954 0.5547 0.6096
0.0967 0.5541 0.609
0.0923 0.2639 0.2636
0.0942 0.5554 0.6109
0.0986 0.5537 0.609
0.4821 0.305 1
0.1416 0.3215 0.3215
0.0334 0.5836 0.6701
0.1727 0.2764 1
0.0575 0.4026 1
0.0577 0.6239 0.7795
0.0599 0.3228 0.7755
0.1727 0.2764 1
0.0892 0.6468 0.7072
0.0282 0.2835 1
0.3872 0.3347 0.3656
0.0541 0.3643 1
0.0333 0.5836 0.6701
0.0333 0.385 1
0.0333 0.6301 1
0.1963 0.4453 0.4453
0.0825 0.529 1
0.0364 0.634 0.6338
0.1193 0.4645 0.8129
0.0919 0.6461 0.7067
0.0297 0.5799 0.665
0.0945 0.2959 0.2952
0.0333 0.7412 0.7408
0.3045 0.2966 1
0.4821 0.305 1
0.3554 0.447 0.447
0.6939 0.2807 1
0.1161 0.7121 1
0.0593 0.6519 1
0.1412 0.7863 1
0.0622 0.7007 1
0.1146 0.7156 0.7301
0.1505 0.4844 0.4844
0.0965 0.4279 0.4276
0.0552 0.3903 0.5296
0.3393 0.6127 0.6127
0.4206 0.5709 1
0.0954 0.2505 0.55
0.0912 0.3799 0.3796
0.1152 0.7603 1
0.1416 0.3215 0.3215
0.1008 0.5555 0.5892
0.0889 0.6482 0.7086
0.089 0.649 0.7091
0.1505 0.4844 0.4844
0.0269 0.7597 1
0.1024 0.4914 1
0.0556 0.3992 1
0.3411 0.6895 1
0.0633 0.7013 1
0.0974 0.5545 0.6099
0.7881 0.2977 1
0.0552 0.3903 1
0.098 0.5547 0.61
0.3145 0.876 1
0.9141 0.7291 1
0.1399 0.9153 1
0.0603 0.7019 1
0.0825 0.529 1
0.0552 0.3639 0.8314
0.0333 0.4068 1
0.0866 0.6479 0.7078
0.0567 0.9357 0.9354
0.0966 0.559 0.6142
0.0333 0.3671 1
0.1152 0.7603 1
0.1727 0.2764 1
0.1193 0.4645 0.8129
0.0836 0.8524 1
0.4802 0.3126 0.5047
0.1152 0.7603 1
0.0552 0.3638 0.8312
0.0869 0.3799 0.3798
0.0275 0.56 0.6326
0.0573 0.3419 1
0.0333 0.4368 0.4368
1.0705 0.4836 0.4836
0.0962 0.5558 0.611
0.1587 0.5194 0.5192
0.1445 0.3757 0.3757
0.0825 0.284 0.7838
0.0543 0.3225 0.3225
0.0552 0.3906 1
0.0333 0.3458 1
0.0825 0.2875 0.8405
0.0954 0.555 0.6101
0.0333 0.357 1
0.1026 0.3739 0.6122
0.027 0.487 0.487
0.0667 0.8024 1
0.09 0.647 0.7072
0.1163 0.3402 1
0.0887 0.6462 0.7062
0.1017 0.554 0.591
0.3411 0.6895 1
0.1512 0.5194 0.5192
0.092 0.6466 0.7072
0.0595 0.7383 1
0.1227 0.5307 0.5
0.0874 0.6484 0.7078
0.0594 0.7085 1
0.0544 0.5539 0.6905
0.0873 0.6465 0.7071
0.0992 0.5542 0.6093
0.0556 0.3992 1
0.0333 0.357 1
0.0882 0.3296 0.3526
0.0879 0.6479 0.7084
0.0771 0.4239 0.4239
0.1429 0.3999 0.7211
0.0333 0.357 1
0.0612 0.7015 1
0.0855 0.9766 1
0.0825 0.284 0.7838
0.2688 0.3293 0.694
0.1119 0.3597 0.3597
0.1412 0.7863 1
0.0825 0.2806 0.6624
0.1933 0.9826 0.9826
0.0859 0.9877 1
0.0667 0.888 1
0.1502 0.5211 0.5211
0.1405 0.752 1
0.028 0.3484 0.3484
0.0999 0.5544 0.6099
0.0962 0.5558 0.611
0.0333 0.385 1
0.0882 0.6464 0.7067
0.028 0.3327 0.5149
0.1502 0.5203 0.5202
0.0267 0.2851 1
0.1023 0.5572 0.6121
0.0597 0.3558 0.7112
0.0886 0.5523 1
0.0667 0.3589 0.3589
0.0567 0.4758 0.4758
0.0949 0.5541 0.6095
0.4821 0.305 1
0.0268 0.4046 0.7764
0.0333 0.4368 0.4368
0.0746 0.2522 1
0.0268 0.2619 0.2613
0.0137 0.5836 0.6701
0.0618 0.9678 1
0.0825 0.529 1
0.187 0.6465 1
0.2549 0.6519 1
0.1587 0.5194 0.5192
0.0279 0.2783 0.6568
0.094 0.5531 0.608
0.0889 0.6478 0.7083
0.0667 0.3589 0.3589
0.0822 0.9764 1
0.1587 0.5194 0.5192
0.1193 0.4645 0.8129
0.0333 0.7848 0
0.0708 0.6843 0
0.0551 0.5514 1
0.0881 0.6463 0.7067
0.0262 0.6917 0.6917
0.0641 0.4816 0.7447
0.0906 0.6479 0.7084
0.4644 0.7284 1
0.0267 0.6326 1
0.0869 0.6447 0.705
0.0918 0.6462 0.7062
0.0593 0.6519 1
0.3411 0.6895 1
0.4821 0.305 1
0.0699 0.6466 0.7912
0.1227 0.5307 0.5
0.0276 0.7725 1
0.1021 0.5543 0.5899
0.4821 0.305 1
0.4821 0.305 1
0.0641 0.4816 0.7447
0.028 0.7811 1
0.7881 0.2977 1
0.1445 0.3757 0.3757
0.0939 0.554 0.6093
0.0825 0.529 1
0.2562 0.4301 1
0.1152 0.7603 1
0.0613 0.7611 1
0.0934 0.5534 0.6087
0.0556 0.4652 0.4652
0.1512 0.5194 0.5192
0.0278 0.2504 1
0.0593 0.5088 1
0.0549 0.5661 0.5661
0.3411 0.6895 1
0.1737 0.5389 0.5389
0.0333 0.34 0.34
0.0333 0.3458 1
0.071 0.7214 1
0.2247 0.4101 0.4099
0.2306 0.4654 0.4654
0.1505 0.4844 0.4844
0.2562 0.4301 1
0.1416 0.3215 0.3215
0.1737 0.5389 0.5389
0.5173 0.2857 0.2857
0.0667 0.8024 1
0.0573 0.3419 1
0.4821 0.305 1
0.0556 0.3992 1
0.0974 0.5542 0.6096
0.3145 0.876 1
0.0918 0.6461 0.7068
0.0333 0.3963 0.106
0.0286 0.3937 1
0.1152 0.7603 1
0.4821 0.305 1
0.1818 0.4167 1
0.0933 0.5581 0.8394
0.2495 0.3294 0.6937
0.0962 0.555 0.6103
0.0309 0.5836 0.6701
0.0585 0.5815 0.6598
0.0902 0.6458 0.7063
0.0311 0.338 0.6846
0.0272 0.3163 0.6018
0.0124 0.5836 0.6701
0.0551 0.5797 1
0.1172 0.3419 0.7986
0.0554 0.694 0.9102
0.0608 0.4913 1
0.0825 0.529 1
0.0901 0.6455 0.7049
0.0552 0.3891 1
0.0333 0.7886 1
0.0333 0.3692 1
0.0297 0.5799 0.665
0.1727 0.2764 1
0.0667 0.9853 0.9853
0.0988 0.5542 0.6096
0.0576 0.4078 0.4078
0.0333 0.297 1
0.0275 0.2865 1
0.028 0.3538 1
0.0287 0.5973 0.5973
0.03 0.6964 1
0.418779 0.5 0.5
0.0825 0.529 1
0.0334 0.5836 0.6701
0.0333 0.5836 0.6701
0.0906 0.6464 0.7068
0.0951 0.5554 0.6102
0.0998 0.5548 0.6101
0.0544 0.2625 0.2624
0.0868 0.6484 0.7084
0.1034 0.627 1
0.3411 0.6895 1
0.1412 0.7863 1
0.0992 0.5537 0.609
0.0923 0.2639 0.2636
0.0954 0.2505 0.55
0.0667 0.2705 0.2843
0.0538 0.3445 0.344
0.115 0.7853 0.7853
0.1405 0.752 1
0.4061 0.5325 1
0.071 0.7214 1
0.0279 0.2876 0.2876
0.1727 0.2768 1
0.4821 0.305 1
0.1727 0.2764 1
0.0873 0.647 0.7074
0.0804 0.5876 0.8687
0.0919 0.6461 0.7067
0.0286 0.3828 1
0.0608 0.883 1
0.1152 0.7603 1
0.061 0.6762 1
0.0554 0.694 0.9102
0.1028 0.5544 0.5903
0.0333 0.4023 1
0.1877 0.5104 1
0.1512 0.5194 0.5192
0.0267 0.2855 0.8809
0.4821 0.305 1
0.0667 0.895 1
0.1152 0.7603 1
0.0268 0.4046 0.7764
0.0923 0.2639 0.2636
0.1008 0.5555 0.5892
0.0535 0.3562 0.3562
0.0667 0.9853 0.9853
0.1416 0.3215 0.3215
0.1096 0.4949 0.4949
0.0882 0.6458 0.7062
0.4821 0.305 1
0.0869 0.3799 0.3798
0.0919 0.6463 0.7064
0.3198 0.8417 0.8415
0.0551 0.3776 1
0.0708 0.318 0.4964
0.0333 0.4419 0.5032
0.0951 0.5562 0.6116
0.1737 0.5389 0.5389
0.0293 0.3223 0.3545
0.3145 0.876 1
0.3411 0.6895 1
0.3679 0.5006 0.5006
0.0919 0.6461 0.7067
0.0267 0.3139 1
0.2828 0.4977 1
0.0962 0.5558 0.611
0.1152 0.7603 1
0.0576 0.4078 0.4078
0.0333 0.3458 1
0.1416 0.3215 0.3215
0.0442 0.2616 0.8904
0.0825 0.284 0.7838
0.0262 0.6917 0.6917
0.0667 0.2705 0.2843
0.254558 1 1
0.0285 0.5632 0.9364
0.3411 0.6895 1
0.111 0.4498 0.4493
0.0333 0.4608 0.4604
0.0272 0.8987 1
0.4198 0.2769 0.7198
0.0945 0.555 0.6103
0.4821 0.305 1
0.0967 0.5552 0.6105
0.0545 0.4201 1
0.1421 0.9293 1
0.091 0.6479 0.7084
0.0906 0.6465 0.7068
0.0554 0.694 0.9102
0.0954 0.2505 0.55
0.0923 0.3466 0.3464
0.0974 0.5542 0.6096
0.1676 0.4205 0.4176
0.0853 0.6054 1
0.0923 0.2639 0.2636
0.4779 0.835 1
0.1764 0.4408 0.4408
0.0271 0.4588 1
0.1703 0.4304 0.4304
0.0641 0.4816 0.7447
0.0954 0.2505 0.55
0.1017 0.554 0.591
0.0667 0.3509 0.4415
0.0333 0.3941 0.7214
0.0278 0.6068 1
0.0556 0.3992 1
0.027 0.487 0.487
0.0667 0.9853 0.9853
0.0333 0.3224 0.4464
0.0825 0.529 1
0.1512 0.5197 0.5192
0.0667 0.7136 0.8864
0.1146 0.7129 0.7273
0.1416 0.3215 0.3215
0.0533 0.36 1
0.1072 0.5542 0.6096
0.0294 0.3071 0.5172
0.1143 0.5941 0.5941
0.1112 0.5109 0.5109
0.0866 0.6169 1
0.2306 0.4654 0.4654
0.0825 0.2806 0.6624
0.0825 0.2875 0.8405
1.1133 0.9328 1
0.1057 0.5543 0.6097

Assayability

Assay information

No assay information for this target.

Reagent availability

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Gene identifier Bm1_41455 (Brugia malayi), NNMT/PNMT/TEMT family protein
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