Detailed view for Bm1_00410

Basic information

TDR Targets ID: 239874
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 5.4293 | Length (AA): 214 | MW (Da): 24542 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01564   Spermine/spermidine synthase domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 195 2e5w (A) 24 223 19.00 0.000000076 0.83 1.10104 -0.43
24 195 3gjy (A) 60 222 14.00 0.0000000035 0.65 0.993238 -0.46
41 169 2i7c (A) 66 190 29.00 0 1 0.911404 -0.43
41 169 2q41 (A) 109 234 23.00 0 0.99 0.856404 -0.4
55 127 3dtn (A) 45 111 37.00 0.02 0.2 0.576421 0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127173)

Species Accession Gene Product
Arabidopsis thaliana AT3G60910   S-adenosyl-L-methionine-dependent methyltransferase-like protein
Arabidopsis thaliana AT2G31740   S-adenosylmethionine-dependent methyltransferase domain-containing protein
Arabidopsis thaliana AT4G34360   S-adenosyl-L-methionine-dependent methyltransferase-like protein
Arabidopsis thaliana AT3G17365   S-adenosyl-L-methionine-dependent methyltransferase-like protein
Babesia bovis BBOV_IV005270   membrane protein, putative
Babesia bovis BBOV_II003780   hypothetical protein
Brugia malayi Bm1_00410   hypothetical protein
Brugia malayi Bm1_54620   Spermine/spermidine synthase family protein
Caenorhabditis elegans CELE_C17E4.11   Protein C17E4.11
Caenorhabditis elegans CELE_C01B10.8   Protein C01B10.8
Cryptosporidium hominis Chro.30168   P0700D12.13
Cryptosporidium hominis Chro.60327   CG2614 protein
Cryptosporidium parvum cgd6_2820   2 SAM dependent methyltransferase; S-adenosyl-L-methionine-dependent methyltransferases + spermidine synthase (SAM dependent met
Cryptosporidium parvum cgd3_1360   methylase
Dictyostelium discoideum DDB_G0280123   hypothetical protein
Dictyostelium discoideum DDB_G0282393   hypothetical protein
Drosophila melanogaster Dmel_CG2614   CG2614 gene product from transcript CG2614-RA
Echinococcus granulosus EgrG_000121700   methyltransferase protein 13
Entamoeba histolytica EHI_092620   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000121700   methyltransferase protein 13
Giardia lamblia GL50803_4349   Endothelin-converting enzyme 2
Homo sapiens ENSG00000010165   methyltransferase like 13
Leishmania braziliensis LbrM.05.1100   hypothetical protein, conserved
Leishmania donovani LdBPK_051100.1   methyltransferase domain containing protein, putative
Leishmania infantum LinJ.05.1100   hypothetical protein, conserved
Leishmania major LmjF.05.1100   hypothetical protein, conserved
Leishmania mexicana LmxM.05.1100   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_13262   hypothetical protein
Loa Loa (eye worm) LOAG_11489   hypothetical protein
Loa Loa (eye worm) LOAG_12643   hypothetical protein
Mus musculus ENSMUSG00000022842   endothelin converting enzyme 2
Mus musculus 71449   methyltransferase like 13
Neospora caninum NCLIV_005320   hypothetical protein
Neospora caninum NCLIV_054190   hypothetical protein
Neospora caninum NCLIV_013470   Spermine/spermidine synthase family protein, related
Oryza sativa 4350724   Os11g0557700
Oryza sativa 4346041   Os08g0517600
Oryza sativa 4335621   Os04g0379300
Onchocerca volvulus OVOC3395  
Plasmodium berghei PBANKA_1006900   conserved Plasmodium protein, unknown function
Plasmodium berghei PBANKA_1318900   methyltransferase, putative
Plasmodium falciparum PF3D7_0409300   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1455200   methyltransferase, putative, unspecified product
Plasmodium knowlesi PKNH_1226800   methyltransferase, putative
Plasmodium knowlesi PKNH_0307400   S-adenosyl-L-methionine-dependent methyltransferase, putative
Plasmodium vivax PVX_000780   hypothetical protein, conserved
Plasmodium yoelii PY04095   hypothetical protein
Plasmodium yoelii PY00864   unknown protein-related
Schmidtea mediterranea mk4.000217.15  
Trypanosoma brucei gambiense Tbg972.7.8060   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.6890   methyltransferase domain containing protein, putative
Trypanosoma congolense TcIL3000_7_5550   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508389.10   methyltransferase domain containing protein, putative
Trypanosoma cruzi TcCLB.506789.120   methyltransferase domain containing protein, putative
Toxoplasma gondii TGME49_213740   hypothetical protein
Toxoplasma gondii TGME49_310070   methyltransferase, putative
Toxoplasma gondii TGME49_221818   hypothetical protein
Theileria parva TP01_0211   hypothetical protein
Theileria parva TP04_0198   hypothetical protein, conserved
Trichomonas vaginalis TVAG_365940   conserved hypothetical protein
Trichomonas vaginalis TVAG_093950   conserved hypothetical protein
Trichomonas vaginalis TVAG_376050   conserved hypothetical protein
Trichomonas vaginalis TVAG_TEG_DS113583_1_26   Maverick transposable element conserved hypothetical protein
Trichomonas vaginalis TVAG_309010   conserved hypothetical protein
Trichomonas vaginalis TVAG_081710   conserved hypothetical protein
Trichomonas vaginalis TVAG_255110   conserved hypothetical protein
Trichomonas vaginalis TVAG_040100   conserved hypothetical protein

Essentiality

Bm1_00410 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.6890 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.6890 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.6890 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.6890 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C17E4.11 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1006900 Plasmodium berghei Dispensable plasmo
TGME49_213740 Toxoplasma gondii Probably non-essential sidik
TGME49_221818 Toxoplasma gondii Probably non-essential sidik
TGME49_310070 Toxoplasma gondii Probably non-essential sidik
TGME49_213740 Toxoplasma gondii Essentiality uncertain sidik
TGME49_221818 Toxoplasma gondii Essentiality uncertain sidik
TGME49_310070 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0373 0.2511 0.2739
0.0369 0.2502 0.2726
0.0379 0.2542 0.2781
0.0361 0.2541 0.2775
0.038 0.2526 0.2762
0.0357 0.2521 0.2753
0.036 0.2545 0.2773

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00410 (Brugia malayi), hypothetical protein
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