Detailed view for Bm1_49775

Basic information

TDR Targets ID: 240240
Brugia malayi, aryl hydrocarbon receptor nuclear translocator protein, putative
Source Database / ID:  GenBank

pI: 7.2411 | Length (AA): 493 | MW (Da): 55171 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00010   Helix-loop-helix DNA-binding domain
PF13426   PAS domain
PF14598   PAS domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005737   cytoplasm  
GO:0005667   transcription factor complex  
GO:0005634   nucleus  
GO:0004871   signal transducer activity  
GO:0003700   transcription factor activity  
GO:0046983   protein dimerization activity  
GO:0030528   transcription regulator activity  
GO:0045449   regulation of transcription  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
63 411 4zpr (A) 87 464 58.00 0 1 0.734911 1.62
308 407 3mjq (A) 6 103 8.00 0 0.15 0.28704 -0.52
309 408 3f1p (A) 240 341 17.00 0 0.8 0.45104 -0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131822)

Species Accession Gene Product
Brugia malayi Bm1_49775   aryl hydrocarbon receptor nuclear translocator protein, putative
Caenorhabditis elegans CELE_C25A1.11   Protein AHA-1, isoform B
Drosophila melanogaster Dmel_CG11987   tango
Echinococcus granulosus EgrG_000805200   Aryl hydrocarbon receptor nuclear
Echinococcus multilocularis EmuJ_000805200   Aryl hydrocarbon receptor nuclear
Homo sapiens ENSG00000143437   aryl hydrocarbon receptor nuclear translocator
Homo sapiens ENSG00000172379   aryl-hydrocarbon receptor nuclear translocator 2
Loa Loa (eye worm) LOAG_08661   aryl Hydrocarbon receptor Associated protein family member
Mus musculus ENSMUSG00000015709   aryl hydrocarbon receptor nuclear translocator 2
Mus musculus ENSMUSG00000015522   aryl hydrocarbon receptor nuclear translocator
Schistosoma japonicum Sjp_0032540   IPR011598,Helix-loop-helix DNA-binding,domain-containing
Schistosoma japonicum Sjp_0303860   ko:K09097 hypoxia-inducible factor 1 beta, putative
Schistosoma japonicum Sjp_0204410   expressed protein
Schistosoma mansoni Smp_123420   aryl hydrocarbon receptor nuclear translocator homolog (darnt)
Schmidtea mediterranea mk4.033968.00   Aryl hydrocarbon receptor nuclear translocator homolog
Schmidtea mediterranea mk4.029278.00   Aryl hydrocarbon receptor nuclear translocator homolog
Schmidtea mediterranea mk4.004916.01   Arnt protein

Essentiality

Bm1_49775 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C25A1.11 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens aryl hydrocarbon receptor nuclear translocator Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.011 0.3411 0.6863
0.0256 0.2566 0.3761
0.0246 0.3026 0.4737
0.0102 0.2663 0.2663
0.0255 0.2575 0.2717
0.0246 0.3026 0.4737
0.0038 0.2705 0.2705
0.0255 0.2601 0.2601
0.0334 0.3657 0.3655
0.07 0.3378 0.3365
0.0263 0.2717 0.2717
0.0109 0.3418 0.6788
0.0992 0.3876 0.3874
0.004 0.4426 0.4467
0.0513 0.2944 0.2937
0.0246 0.3026 0.4737
0.0067 0.4404 0.397
0.0181 0.3086 0.3086
0.0255 0.2601 0.2601
0.0067 0.6459 0.6476
0.0045 0.2705 0.2705
0.0466 0.2976 0.2965
0.0466 0.2976 0.2965
0.0045 0.2897 0.2897
0.0992 0.3876 0.3874
0.0102 0.2696 0.2684
0.0045 0.442 0.442
0.004 0.4426 0.4467
0.0605 0.2887 0.2885
0.0232 0.3104 0.4876
0.0335 0.386 0.3859
0.0718 0.2732 0.2717
0.0513 0.2944 0.2937
0.0045 0.4706 0.5551
0.0262 0.3039 0.3039
0.0262 0.2842 0.3597
0.019 0.2663 0.2663
0.0262 0.3039 0.3039
0.0525 0.2611 0.261
0.036 0.385 0.385
0.011 0.3411 0.6863
0.0795 0.3862 0.3862
0.0827 0.3874 0.3869
0.0065 0.2583 0.4795
0.011 0.3411 0.6863
0.0424 0.2684 0.2684
0.0356 0.2663 0.2663
0.0261 0.2777 0.2765
0.0996 0.3712 0.3706
0.0038 0.2653 0.0513
0.0027 0.2705 0.2705
0.0169 0.3669 0.3669
0.079 0.355 0.355
0.0266 0.3896 0.3892
0.0067 0.33 0.33
0.0102 0.2721 0.2721
0.0039 0.5738 0.5779
0.0696 0.3881 0.3881
0.0234 0.3122 0.4898
0.0366 0.3854 0.3794
0.0892 0.3542 0.3538
0.0473 0.2663 0.2663
0.0243 0.2853 0.3448

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_49775 (Brugia malayi), aryl hydrocarbon receptor nuclear translocator protein, putative
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