pI: 6.702 |
Length (AA): 397 |
MW (Da): 44849 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
31 | 361 | 3elb (A) | 20 | 351 | 63.00 | 0 | 1 | 1.50765 | -0.62 |
34 | 155 | 3glv (A) | 2 | 120 | 26.00 | 0 | 1 | 0.713605 | -0.87 |
191 | 393 | 4mvc (A) | 43 | 291 | 30.00 | 0 | 1 | 0.889235 | -0.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127671)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G38670 | ethanolamine-phosphate cytidylyltransferase |
Babesia bovis | BBOV_I004300 | ethanolamine-phosphate cytidylyltransferase, putative |
Brugia malayi | Bm1_01855 | ethanolamine-phosphate cytidylyltransferase |
Candida albicans | CaO19.2107 | Ethanolaminephosphate cytidylyltransferase |
Candida albicans | CaO19.9655 | Ethanolaminephosphate cytidylyltransferase |
Caenorhabditis elegans | CELE_Y37E3.11 | Protein Y37E3.11, isoform B |
Cryptosporidium hominis | Chro.70332 | CTP:ethanolamine cytidylyltransferase |
Cryptosporidium parvum | cgd7_2950 | phospholipid cytidyltransferase HIGH family |
Dictyostelium discoideum | DDB_G0270298 | cytidylyltransferase domain-containing protein |
Drosophila melanogaster | Dmel_CG5547 | Phosphoethanolamine cytidylyltransferase |
Echinococcus granulosus | EgrG_000163700 | Rossmann alpha beta alpha sandwich fold |
Entamoeba histolytica | EHI_140590 | phospholipid cytidylyltransferase, putative |
Entamoeba histolytica | EHI_095120 | phospholipid cytidylyltransferase, putative |
Echinococcus multilocularis | EmuJ_000163700 | Rossmann alpha beta alpha sandwich fold |
Homo sapiens | 5833 | phosphate cytidylyltransferase 2, ethanolamine |
Leishmania braziliensis | LbrM.32.0980 | ethanolamine-phosphate cytidylyltransferase, putative |
Leishmania donovani | LdBPK_320940.1 | ethanolamine-phosphate cytidylyltransferase |
Leishmania infantum | LinJ.32.0940 | ethanolamine-phosphate cytidylyltransferase, putative |
Leishmania major | LmjF.32.0890 | ethanolamine-phosphate cytidylyltransferase, putative |
Leishmania mexicana | LmxM.31.0890 | ethanolamine-phosphate cytidylyltransferase, putative |
Loa Loa (eye worm) | LOAG_12463 | ethanolamine-phosphate cytidylyltransferase |
Loa Loa (eye worm) | LOAG_15371 | hypothetical protein |
Mus musculus | ENSMUSG00000025137 | phosphate cytidylyltransferase 2, ethanolamine |
Neospora caninum | NCLIV_054370 | phosphoethanolamine cytidylyltransferase, putative |
Oryza sativa | 4349636 | Os11g0123400 |
Oryza sativa | 4351359 | Os12g0121300 |
Oryza sativa | 4344972 | Os08g0224800 |
Oryza sativa | 4348512 | Os10g0387000 |
Plasmodium berghei | PBANKA_1360500 | ethanolamine-phosphate cytidylyltransferase |
Plasmodium falciparum | PF3D7_1347700 | ethanolamine-phosphate cytidylyltransferase |
Plasmodium knowlesi | PKNH_1253200 | ethanolamine-phosphate cytidylyltransferase, putative |
Plasmodium vivax | PVX_083280 | ethanolamine-phosphate cytidylyltransferase, putative |
Plasmodium yoelii | PY06073 | hypothetical protein |
Saccharomyces cerevisiae | YGR007W | ethanolamine-phosphate cytidylyltransferase |
Schistosoma japonicum | Sjp_0030910 | ko:K00967 ethanolamine-phosphate cytidylyltransferase [EC2.7.7.14], putative |
Schistosoma japonicum | Sjp_0030900 | ko:K00876 uridine kinase [EC2.7.1.48], putative |
Schistosoma mansoni | Smp_158130 | ethanolamine-phosphate cytidylyltransferase |
Schmidtea mediterranea | mk4.001631.02 | |
Trypanosoma brucei gambiense | Tbg972.11.15800 | ethanolamine-phosphate cytidylyltransferase, putative |
Trypanosoma brucei | Tb927.11.14140 | ethanolamine-phosphate cytidylyltransferase |
Trypanosoma congolense | TcIL3000_0_31410 | ethanolamine-phosphate cytidylyltransferase |
Trypanosoma congolense | TcIL3000.11.14440 | ethanolamine-phosphate cytidylyltransferase |
Trypanosoma cruzi | TcCLB.511727.120 | ethanolamine-phosphate cytidylyltransferase |
Toxoplasma gondii | TGME49_310280 | Phosphoethanolamine-cytidyltransferase |
Theileria parva | TP04_0187 | ethanolamine-phosphate cytidylyltransferase, putative |
Trichomonas vaginalis | TVAG_327610 | ethanolamine-phosphate cytidylyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.5730 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5730 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5730 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.5730 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y37E3.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y37E3.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y37E3.11 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1360500 | Plasmodium berghei | Slow | plasmo |
TGME49_310280 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.