Detailed view for Bm1_45830

Basic information

TDR Targets ID: 241738
Brugia malayi, metallo-beta-lactamase superfamily protein
Source Database / ID:  GenBank

pI: 8.3521 | Length (AA): 350 | MW (Da): 39688 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00753   Metallo-beta-lactamase superfamily
PF16123   Hydroxyacylglutathione hydrolase C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0019243   methylglyoxal catabolic process to D-lactate  
GO:0016787   hydrolase activity  
GO:0004416   hydroxyacylglutathione hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 124 3hgt (A) 153 261 37.00 0.33 0.43 0.450814 0.6
47 297 2p18 (A) 6 289 33.00 0 1 1.17004 -1.31
52 330 2qed (A) 0 251 32.00 0 1 1.22804 -1.18
75 128 2p4z (A) 42 98 37.00 0.68 0.92 0.542386 -0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_141722)

Species Accession Gene Product
Brugia malayi Bm1_45830   metallo-beta-lactamase superfamily protein
Homo sapiens ENSG00000127838   paroxysmal nonkinesigenic dyskinesia
Loa Loa (eye worm) LOAG_01519   hydroxyacylglutathione hydrolase cytoplasmic
Mus musculus ENSMUSG00000026179   paroxysmal nonkinesiogenic dyskinesia
Onchocerca volvulus OVOC8654   Putative hydrolase PNKD
Schmidtea mediterranea mk4.002069.04   Probable hydrolase PNKD
Schmidtea mediterranea mk4.000838.00   Probable hydrolase PNKD
Schmidtea mediterranea mk4.004560.00   Probable hydrolase PNKD

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 295 aa 34.4% 270 aa Compounds References
Rattus norvegicus Glyoxalase II 309 aa 33.8% 260 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0115 1 1
0.03 0.9089 1
0.0367 0.531 1
0.0138 0.8072 0.8072
0.035 0.2506 0.7714
0.0404 0.2792 0.8391
0.0156 1 1
0.0286 1 1
0.024 0.347 1
0.0065 0.5 0.5
0.0088 0.4106 1
0.0101 0.5 0.5
0.0249 0.3365 1
0.0085 0.271 0.271
0.0031 0.5 0.5
0.0134 0.3422 0.9218
0.032 0.4025 1
0.0282 0.3876 1
0.0259 0.336 0.9793
0.0153 1 1
0.0051 0.5023 0.5023
0.0284 0.6112 1
0.0098 0.5 0.5
0.0019 0.5 0.5
0.0173 0.5058 1
0.0161 1 1
0.0333 0.487 1
0.0151 0.5 0.5
0.0068 0.616 0.616
0.0139 0.3313 0.3601
0.0141 0.5 0.5
0.0153 1 1
0.0304 0.3722 1
0.0215 0.5175 0
0.0183 1 1
0.0101 0.5 0.5
0.0208 0.4509 0.8928
0.0079 0.301 0.3447
0.0263 0.5703 1
0.0033 0.5 0.5
0.0304 0.3722 1
0.0224 1 1
0.03 0.9089 1
0.0307 0.4131 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_45830 (Brugia malayi), metallo-beta-lactamase superfamily protein
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