pI: 4.2151 |
Length (AA): 168 |
MW (Da): 19264 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 167 | 2ast (A) | 1003 | 1155 | 76.00 | 0 | 1 | 1.72908 | -1.1 |
10 | 167 | 3ogk (A) | 5 | 153 | 62.00 | 0 | 1 | 1.61308 | -1 |
10 | 167 | 2ast (A) | 1003 | 1155 | 76.00 | 0 | 1 | 1.72978 | -1.12 |
10 | 167 | 3ogk (A) | 5 | 153 | 62.00 | 0 | 1 | 1.60848 | -0.96 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127430)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G60010 | SKP1-like protein 13 |
Arabidopsis thaliana | AT4G34470 | SKP1-like protein 12 |
Arabidopsis thaliana | AT4G34210 | SKP1-like protein 11 |
Arabidopsis thaliana | AT5G42190 | SKP1-like protein 1B |
Arabidopsis thaliana | AT1G75950 | S-phase kinase-associated protein 1 |
Babesia bovis | BBOV_IV006860 | cytosolic glycoprotein FP21, putative |
Brugia malayi | Bm1_00275 | S-phase kinase-associated protein SKR-1 |
Candida albicans | CaO19.4427 | kinetochore complex |
Candida albicans | CaO19.11905 | kinetochore complex |
Caenorhabditis elegans | CELE_F46A9.4 | Protein SKR-2 |
Caenorhabditis elegans | CELE_F46A9.5 | Protein SKR-1 |
Cryptosporidium parvum | cgd7_2500 | Skp1 family protein, putative |
Dictyostelium discoideum | DDB_G0273615 | cytosolic glycoprotein FP21 |
Dictyostelium discoideum | DDB_G0269230 | cytosolic glycoprotein FP21 |
Dictyostelium discoideum | DDB_G0273251 | cytosolic glycoprotein FP21 |
Drosophila melanogaster | Dmel_CG12227 | CG12227 gene product from transcript CG12227-RA |
Drosophila melanogaster | Dmel_CG43089 | CG43089 gene product from transcript CG43089-RC |
Drosophila melanogaster | Dmel_CG16983 | CG16983 gene product from transcript CG16983-RD |
Echinococcus granulosus | EgrG_000965900 | S phase kinase associated protein SKR 1 |
Echinococcus granulosus | EgrG_000965600 | S phase kinase associated protein 1 |
Entamoeba histolytica | EHI_118670 | Skp1 family protein |
Echinococcus multilocularis | EmuJ_000965900 | S phase kinase associated protein SKR 1 |
Echinococcus multilocularis | EmuJ_000965600 | S phase kinase associated protein 1 |
Homo sapiens | 6500 | S-phase kinase-associated protein 1 |
Leishmania braziliensis | LbrM.11.0950 | S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein |
Leishmania donovani | LdBPK_111200.1 | SKP1-like protein |
Leishmania infantum | LinJ.11.1200 | S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein |
Leishmania major | LmjF.11.1210 | S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein |
Leishmania mexicana | LmxM.11.1210 | S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein |
Loa Loa (eye worm) | LOAG_02338 | S-phase kinase-associated protein SKR-1 |
Mus musculus | ENSMUSG00000036309 | S-phase kinase-associated protein 1A |
Neospora caninum | NCLIV_002630 | Protein F46A9.4, confirmed by transcript evidence, related |
Oryza sativa | 4345419 | Os08g0375700 |
Oryza sativa | 4347721 | Os09g0539500 |
Oryza sativa | 9270098 | Os11g0456300 |
Oryza sativa | 4346586 | Os09g0273800 |
Oryza sativa | 9267738 | Os02g0101550 |
Onchocerca volvulus | OVOC9486 |
|
Plasmodium berghei | PBANKA_1142900 | suppressor of kinetochore protein 1, putative |
Plasmodium falciparum | PF3D7_1367000 | suppressor of kinetochore protein 1, putative |
Plasmodium knowlesi | PKNH_1104200 | suppressor of kinetochore protein 1, putative |
Plasmodium vivax | PVX_115310 | suppressor of kinetochore protein 1, putative |
Plasmodium yoelii | PY00081 | skp1 |
Saccharomyces cerevisiae | YDR328C | SCF ubiquitin ligase subunit SKP1 |
Schistosoma japonicum | Sjp_0208540 | ko:K03094 S-phase kinase-associated protein 1, putative |
Schistosoma mansoni | Smp_052910 | skp1-related |
Trypanosoma brucei gambiense | Tbg972.11.6910 | S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2-associated protein |
Trypanosoma brucei | Tb927.11.6130 | SKP1-like protein |
Trypanosoma congolense | TcIL3000.11.6650 | SKP1-like protein |
Trypanosoma congolense | TcIL3000.11.6670 | SKP1-like protein |
Trypanosoma cruzi | TcCLB.508041.10 | SKP1-like protein |
Trypanosoma cruzi | TcCLB.506297.350 | SKP1-like protein |
Toxoplasma gondii | TGME49_207680 | suppressor of kinetochore protein 1, putative |
Theileria parva | TP03_0225 | Skp1 protein, putative |
Trichomonas vaginalis | TVAG_098740 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3990 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3990 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3990 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.3990 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F46A9.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F46A9.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F46A9.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F46A9.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F46A9.5 | Caenorhabditis elegans | sterile | wormbase |
CELE_F46A9.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F46A9.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F46A9.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F46A9.4 | Caenorhabditis elegans | sterile | wormbase |
YDR328C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_207680 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.