TDR Targets

Detailed view for Bm1_00260

Basic information

TDR Targets ID: 242558
Brugia malayi, Protein set-1
Source Database / ID: GenBank

pI: 9.7579 | Length (AA): 248 | MW (Da): 28812 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Network

Pfam domains

PF00856 SET domain

Gene Ontology

Mouse over links to read term descriptions.

GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity

Metabolic Pathways

Lysine degradation (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg	Target End	Template	Template Beg	Template End	Identity	Evalue	Model Score	MPQS	zDope
72	237	2w5y (A)	3795	3957	35.00	0	1	1.00865	0.34
86	247	3f9x (A)	193	352	47.00	0	1	1.25553	-0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130816)

Species	Accession	Gene Product
Babesia bovis	BBOV_IV004680	SET domain containing protein
Brugia malayi	Bm1_00260	Protein set-1
Caenorhabditis elegans	CELE_T26A5.7	Protein SET-1, isoform B
Cryptosporidium hominis	Chro.40051	SET domain
Cryptosporidium parvum	cgd4_370	protein with a SET domain within carboxy region
Drosophila melanogaster	Dmel_CG3307	CG3307 gene product from transcript CG3307-RB
Echinococcus granulosus	EgrG_001031500	histone lysine n methyltransferase setd8
Echinococcus multilocularis	EmuJ_001031500	histone lysine n methyltransferase setd8
Homo sapiens	ENSG00000183955	SET domain containing (lysine methyltransferase) 8
Loa Loa (eye worm)	LOAG_02341	hypothetical protein
Mus musculus	ENSMUSG00000049327	SET domain containing (lysine methyltransferase) 8
Neospora caninum	NCLIV_011360	SET domain-containing protein, putative
Plasmodium berghei	PBANKA_1001600	SET domain protein, putative
Plasmodium falciparum	PF3D7_0403900	SET domain protein, putative
Plasmodium knowlesi	PKNH_0301900	SET domain protein, putative
Plasmodium vivax	PVX_001050	SET domain protein, putative
Plasmodium yoelii	PY01349	SET domain, putative
Schistosoma japonicum	Sjp_0109250	IPR001214,SET,domain-containing
Schistosoma japonicum	Sjp_0018990	Histone-lysine N-methyltransferase SETD8, putative
Schistosoma mansoni	Smp_055310	histone-lysine n-methyltransferase seto7
Schmidtea mediterranea	mk4.004321.01	SETD8-1
Toxoplasma gondii	TGME49_211730	histone lysine methyltransferase SET8
Theileria parva	TP01_0281	hypothetical protein

Essentiality

Bm1_00260 has one or more orthologs with essentiality data

Gene/Ortholog	Organism	Phenotype	Source Study
CELE_T26A5.7	Caenorhabditis elegans	embryonic lethal	wormbase
CELE_T26A5.7	Caenorhabditis elegans	larval arrest	wormbase
CELE_T26A5.7	Caenorhabditis elegans	larval lethal	wormbase
CELE_T26A5.7	Caenorhabditis elegans	slow growth	wormbase
PBANKA_1001600	Plasmodium berghei	Slow	plasmo
TGME49_211730	Toxoplasma gondii	Essentiality uncertain	sidik

Show/Hide essentiality data references

yeastgenome

Systematic deletion of yeast genes

Saccharomyces Genome Database

blattner

Systematic mutagenesis of the E. coli (MG1655) genome

J Bacteriol 2004, 186:4921-4930

plasmo

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

shigen

Profiling of E. coli Chromosome (PEC)

National Institute of Genetics, Japan

neb

C. elegans RNAi phenotypes

Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

alsford

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

Genome Res 2011, 21:915-924

nmpdr

Genome-scale essentiality datasets from published studies (M. tuberculosis)

National Microbial Pathogen Data Resource

gerdes

Experimental determination and system-level analysis of essential genes in E. coli MG1655

Gerdes et al., J Bacteriol. 2003 185:5673-84

keio

Systematic single-gene knock-out mutants of E. coli K12

The Keio Collection

sidik

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.

Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

wormbase

C. elegans RNAi experiments

WormBase web site, http://www.wormbase.org, release WS170

goodall

The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis)

Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets

Species	Known druggable target	Linked compounds	Reference
Homo sapiens	SET domain containing (lysine methyltransferase) 8	Compounds	References

By sequence similarity to non orthologous druggable targets

No additional associated druggable targets

Ranking Plot

Putative Drugs List

Raw	Global	Species
0.0473	0.2915	0.372
0.0473	0.2915	0.372
0.0579	0.7829	0.8916
0.0193	0.2616	0.3923
0.0578	0.3861	0.4398
0.0583	0.395	0.449
0.0391	0.76	0.8293
0.0417	0.7389	0
0.0548	0.743	0.8462
0.0548	0.743	0.8462
0.0417	0.6888	0.6888
0.0588	0.295	0.3363
0.0063	0.4053	0.8478
0.0193	0.4031	0.788
0.0394	0.8214	0.9349
0.0589	0.4049	0.4604
0.0579	0.3373	0.3835
0.0399	0.5423	0.6167
0.0391	0.76	0.8293
0.0496	0.5854	1
0.0565	0.7066	0.8861
0.0573	0.3891	0.4423
0.0404	0.3283	0.3739
0.0064	0.2983	0.2983
0.0561	0.8186	1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier	Bm1_00260 (Brugia malayi), Protein set-1

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