Detailed view for Bm1_33655

Basic information

TDR Targets ID: 242941
Brugia malayi, Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X
Source Database / ID:  GenBank

pI: 5.8153 | Length (AA): 513 | MW (Da): 58274 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF08614   Autophagy protein 16 (ATG16)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Regulation of autophagy (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 63 5j0k (A) 9 74 13.00 0.22 0.02 0.216307 -0.64
69 204 4uos (A) 4 140 12.00 0 0.02 0.388907 -1.08
231 499 4j8b (A) 32 327 24.00 0.000000003 1 0.693866 0.34
258 454 2aq5 (A) 84 299 22.00 0.07 0.73 0.563516 0.27
294 500 4wju (A) 138 308 35.00 0.00000000062 0.65 0.503009 0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129719)

Species Accession Gene Product
Arabidopsis thaliana AT5G50230   WD40 domain-containing protein
Brugia malayi Bm1_33655   Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X
Caenorhabditis elegans CELE_K06A1.5   Protein ATG-16.2
Caenorhabditis elegans CELE_F02E8.5   Protein ATG-16.1
Dictyostelium discoideum DDB_G0275323   autophagy protein 16
Drosophila melanogaster Dmel_CG31033   Autophagy-specific gene 16
Echinococcus granulosus EgrG_001095900   family S9 non peptidase ue S09 family
Echinococcus granulosus EgrG_000150900   U6 snRNA associated Sm protein LSm7
Entamoeba histolytica EHI_168370   WD domain containing protein
Echinococcus multilocularis EmuJ_000150900   U6 snRNA associated Sm protein LSm7
Echinococcus multilocularis EmuJ_001095900   family S9 non peptidase ue (S09 family)
Homo sapiens ENSG00000085978   autophagy related 16-like 1 (S. cerevisiae)
Leishmania braziliensis LbrM.33.1680   hypothetical protein, conserved
Leishmania donovani LdBPK_331500.1   hypothetical protein, conserved
Leishmania infantum LinJ.33.1500   hypothetical protein, conserved
Leishmania major LmjF.33.1410   hypothetical protein, conserved
Leishmania mexicana LmxM.32.1410   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_10334   hypothetical protein
Mus musculus ENSMUSG00000026289   autophagy related 16-like 1 (S. cerevisiae)
Oryza sativa 4334090   Os03g0746600
Onchocerca volvulus OVOC2829  
Schistosoma japonicum Sjp_0068360   Autophagy-related protein 16-1, putative
Schistosoma mansoni Smp_135430   family S9 non-peptidase homologue (S09 family)
Schmidtea mediterranea mk4.000410.00  
Trypanosoma brucei gambiense Tbg972.11.7880   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.6960   ATG16/SAP18/CVT11/APG16, putative
Trypanosoma cruzi TcCLB.506775.160   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511167.20   hypothetical protein, conserved
Trichomonas vaginalis TVAG_459010   WD-repeat protein, putative

Essentiality

Bm1_33655 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.4790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.4790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.4790 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.4790 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_33655 (Brugia malayi), Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X
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