Detailed view for Bm1_32610

Basic information

TDR Targets ID: 243265
Brugia malayi, lysosomal alpha-mannosidase, putative
Source Database / ID: GenBank / Bm1_32610

pI: 9.3191 | Length (AA): 831 | MW (Da): 95411 | Number of Paralogs: 0

EC number(s): 3.2.1.24 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: ND

Pfam domains

PF07748   Glyco_hydro_38C
PF09261   Alpha-mann_mid

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003824   catalytic activity  
GO:0030246   carbohydrate binding  
GO:0015923   mannosidase activity  
GO:0008270   zinc ion binding  
GO:0004559   alpha-mannosidase activity  

Process: (mouse over links to read term descriptions)

GO:0006013   mannose metabolic process  
GO:0005975   carbohydrate metabolic process  
Metabolic Pathways

Other glycan degradation (KEGG)
Glycan structures - degradation (KEGG)
Lysosome (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Bm1_32610  

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 33
Cumulative epitope score: 36.5
Normalized epitope score: 4.4
Percentile: 45.4 (this protein belongs to the top 54.6% proteins in the genome of Brugia malayi, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_93490
Number of Paralogs: 0

Ortholog group members from selected species:
Brugia malayi Bm1_32610 (this record).   lysosomal alpha-mannosidase, putative... |   OrthoMCL

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

      • No orthologous druggable targets

    • By sequence similarity to non orthologous druggable targets

      • No additional associated druggable targets
    • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

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    User comments

    No user comments are available for this gene.

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