pI: 6.6865 |
Length (AA): 2507 |
MW (Da): 280420 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 36 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 66 | 2xen (A) | 39 | 102 | 27.00 | 0.00013 | 1 | 0.527327 | -1.68 |
2 | 74 | 5eid (A) | 243 | 314 | 24.00 | 0.0027 | 1 | 0.461518 | -1.29 |
2 | 130 | 2xeh (A) | 39 | 167 | 27.00 | 0.00000000022 | 1 | 0.487856 | -1.03 |
5 | 72 | 2zgd (A) | 10 | 86 | 39.00 | 0.0003 | 1 | 0.554924 | -0.71 |
6 | 116 | 3c5r (A) | 0 | 534 | 18.00 | 0.00015 | 0.99 | 0.370676 | -0.84 |
15 | 117 | 3deo (A) | 133 | 235 | 36.00 | 0.4 | 1 | 0.487885 | -0.4 |
25 | 448 | 4rlv (A) | 2079 | 2524 | 27.00 | 0 | 1 | 0.275926 | 0.5 |
87 | 421 | 1n11 (A) | 415 | 762 | 29.00 | 0 | 1 | 0.264426 | 0.66 |
177 | 269 | 2vge (A) | 623 | 714 | 33.00 | 0.37 | 1 | 0.530896 | -1.17 |
184 | 270 | 3c5r (A) | 431 | 516 | 33.00 | 0.027 | 1 | 0.574503 | -1.43 |
185 | 269 | 4hrm (B) | 51 | 134 | 47.00 | 0.00068 | 1 | 0.542705 | -0.72 |
342 | 417 | 5ja4 (D) | 560 | 622 | 43.00 | 0.027 | 0.99 | 0.310115 | 0.26 |
478 | 968 | 5gr8 (A) | 62 | 583 | 30.00 | 0.000024 | 1 | 0.224652 | 0.98 |
518 | 622 | 2v9t (B) | 326 | 430 | 36.00 | 0.0097 | 1 | 0.497683 | -0.69 |
536 | 628 | 2o6s (A) | 58 | 139 | 43.00 | 0.0075 | 0.91 | 0.335896 | 0.19 |
707 | 771 | 1dce (A) | 481 | 545 | 25.00 | 0 | 0.41 | 0.228827 | -0.29 |
969 | 1386 | 3dpu (A) | 432 | 794 | 24.00 | 0 | 1 | 0.188133 | 0.22 |
974 | 1203 | 3kxi (A) | 163 | 352 | 19.00 | 0 | 1 | -0.0123569 | 0.1 |
975 | 1377 | 4wnr (A) | 307 | 629 | 27.00 | 0 | 1 | 0.26815 | -0.24 |
976 | 1377 | 4wnr (A) | 308 | 629 | 30.00 | 0 | 1 | 0.218151 | 0.39 |
989 | 1139 | 2il1 (A) | 138 | 254 | 36.00 | 0.011 | 0.98 | 0.0700314 | 0.05 |
990 | 1205 | 2zej (A) | 1335 | 1510 | 37.00 | 0 | 0.89 | 0.0260588 | 0.65 |
991 | 1139 | 3tw8 (B) | 10 | 123 | 36.00 | 0.22 | 1 | 0.159234 | -0.23 |
991 | 1139 | 2bcg (Y) | 10 | 124 | 34.00 | 0.56 | 1 | 0.129234 | -0.03 |
1048 | 1142 | 3kkq (A) | 36 | 132 | 22.00 | 0.96 | 0.75 | 0.191294 | 0.75 |
1071 | 1186 | 4js0 (A) | 50 | 176 | 23.00 | 0.81 | 1 | 0.27307 | -0.5 |
1074 | 1162 | 1z0j (A) | 56 | 146 | 25.00 | 0.17 | 0.57 | 0.353901 | -0.78 |
1522 | 2055 | 4oli (A) | 682 | 1170 | 22.00 | 0 | 1 | 0.0684036 | 1.58 |
1759 | 2146 | 5dvr (A) | 49 | 477 | 22.00 | 0 | 1 | 0.169167 | 0.89 |
1759 | 2211 | 3mwu (A) | 74 | 470 | 21.00 | 0 | 0.99 | 0.227094 | 0.56 |
1761 | 2107 | 3lij (A) | 62 | 370 | 23.00 | 0 | 1 | 0.216812 | 0.35 |
1836 | 2052 | 2dq7 (X) | 53 | 258 | 28.00 | 0.00000000023 | 1 | 0.359358 | -0.26 |
1837 | 2051 | 4wkq (A) | 762 | 965 | 29.00 | 0.00000000021 | 1 | 0.37256 | -0.3 |
1880 | 1970 | 4y0x (A) | 242 | 319 | 41.00 | 0.028 | 0.99 | 0.176098 | 0.66 |
1891 | 2101 | 4ci6 (B) | 244 | 427 | 31.00 | 0.87 | 0.24 | 0.120964 | 0.84 |
2263 | 2393 | 1v8p (A) | 12 | 128 | 30.00 | 0.34 | 0.27 | 0.144054 | 0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131478)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_27545 | Protein kinase domain containing protein |
Caenorhabditis elegans | CELE_T27C10.6 | Protein LRK-1 |
Dictyostelium discoideum | DDB_G0269250 | ROCO family protein kinase |
Dictyostelium discoideum | DDB_G0267472 | ROCO family protein kinase |
Drosophila melanogaster | Dmel_CG5483 | Leucine-rich repeat kinase |
Echinococcus granulosus | EgrG_000157950 | leucine rich repeat serine:threonine protein |
Echinococcus multilocularis | EmuJ_000157950 | leucine rich repeat serine:threonine protein |
Homo sapiens | ENSG00000154237 | leucine-rich repeat kinase 1 |
Homo sapiens | ENSG00000188906 | leucine-rich repeat kinase 2 |
Loa Loa (eye worm) | LOAG_02500 | TKL/LRRK protein kinase |
Mus musculus | ENSMUSG00000015133 | leucine-rich repeat kinase 1 |
Mus musculus | ENSMUSG00000036273 | leucine-rich repeat kinase 2 |
Mus musculus | 102641899 | leucine-rich repeat serine/threonine-protein kinase 1-like |
Schmidtea mediterranea | mk4.015658.02 | Leucine-rich repeat serine/threonine-protein kinase 2 |
Schmidtea mediterranea | mk4.015658.01 | Leucine-rich repeat serine/threonine-protein kinase 2 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | leucine-rich repeat kinase 2 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 23.5% | 268 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 23.4% | 248 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 22.5% | 213 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 22.3% | 247 aa | Compounds | References |