Detailed view for Bm1_00805

Basic information

TDR Targets ID: 244288
Brugia malayi, MRG family protein
Source Database / ID:  GenBank

pI: 7.9888 | Length (AA): 389 | MW (Da): 44709 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05712   MRG
PF11717   RNA binding activity-knot of a chromodomain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0006325   establishment and/or maintenance of chromatin architecture  
GO:0005634   nucleus  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 110 2efi (A) 2 98 35.00 0 1 0.620923 -0.05
24 100 5in1 (A) 11 80 34.00 0 1 0.600943 -0.85
24 69 3oa6 (A) 9 64 43.00 0.064 0.94 0.346652 0.72
30 73 3m9q (A) 17 68 41.00 0.32 0.97 0.345511 0.31
115 260 3oam (A) 33 156 28.00 0.37 0.17 0.399721 0.89
172 385 2lkm (B) 153 321 49.00 0 0.99 0.856129 -0.09
175 378 2y0n (A) 172 507 35.00 0 1 0.795422 -0.83
175 378 2y0n (A) 172 507 37.00 0.000000000037 1 0.817822 -0.77

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128923)

Species Accession Gene Product
Arabidopsis thaliana AT4G37280   MRG family protein
Brugia malayi Bm1_00805   MRG family protein
Candida albicans CaO19.2660   similar to S. pombe Chromo domain protein required for cell polarity.
Caenorhabditis elegans CELE_Y37D8A.9   Protein MRG-1, isoform A
Dictyostelium discoideum DDB_G0283075   NuA4 histone H4 acetyltransferase complex subunit
Drosophila melanogaster Dmel_CG6363   CG6363 gene product from transcript CG6363-RA
Echinococcus granulosus EgrG_001091300   Mortality factor 4 protein 1
Entamoeba histolytica EHI_067880   hypothetical protein
Echinococcus multilocularis EmuJ_001091300   Mortality factor 4 protein 1
Homo sapiens ENSG00000185787   mortality factor 4 like 1
Loa Loa (eye worm) LOAG_04297   hypothetical protein
Mus musculus ENSMUSG00000062270   mortality factor 4 like 1
Mus musculus 627352   predicted gene 6747
Oryza sativa 4350689   Os11g0545600
Oryza sativa 4334885   Os04g0101300
Onchocerca volvulus OVOC9397  
Saccharomyces cerevisiae YPR023C   Eaf3p
Schistosoma japonicum Sjp_0211190   expressed protein
Schistosoma japonicum Sjp_0133620   expressed protein
Schistosoma japonicum Sjp_0061420   Mortality factor 4-like protein 1, putative
Schistosoma mansoni Smp_140950   transcription factor mrg-related
Schmidtea mediterranea mk4.007283.00  
Trichomonas vaginalis TVAG_012490   conserved hypothetical protein

Essentiality

Bm1_00805 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y37D8A.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y37D8A.9 Caenorhabditis elegans larval arrest wormbase
CELE_Y37D8A.9 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00805 (Brugia malayi), MRG family protein
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