Detailed view for Bm1_41850

Basic information

TDR Targets ID: 244394
Brugia malayi, Associated with TFs and helicases family protein
Source Database / ID:  GenBank

pI: 6.3626 | Length (AA): 2707 | MW (Da): 304663 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00176   SNF2 family N-terminal domain
PF00271   Helicase conserved C-terminal domain
PF00385   Chromo (CHRromatin Organisation MOdifier) domain
PF07533   BRK domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016817   hydrolase activity, acting on acid anhydrides  
GO:0000785   chromatin  
GO:0005634   nucleus  
GO:0005515   protein binding  
GO:0004386   helicase activity  
GO:0003682   chromatin binding  
GO:0003677   DNA binding  
GO:0003676   nucleic acid binding  
GO:0005524   ATP binding  
GO:0006333   chromatin assembly or disassembly  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
619 792 2fkj (A) 73 244 30.00 0.0029 0.07 0.166978 0.56
657 925 1c1g (A) 11 269 29.00 0.0042 0.04 0.123072 0.82
890 1594 3mwy (W) 177 919 37.00 0 1 0.375236 0.59
968 1018 2epb (A) 371 427 47.00 0.011 0.87 0.40254 0.55
973 1009 4quc (A) 25 61 41.00 0.98 0.49 0.456368 0.08
1364 1492 2p6n (A) 407 523 30.00 0.46 1 0.437354 -0.98
2284 2328 2ckc (A) 2563 2607 64.00 0.000000009 1 0.937324 -1.89
2287 2325 2cka (A) 2033 2071 54.00 0.00063 1 0.839107 -1.93
2582 2697 5n8p (A) 398 534 39.00 0.0012 0.62 0.203552 1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127421)

Species Accession Gene Product
Brugia malayi Bm1_41850   Associated with TFs and helicases family protein
Caenorhabditis elegans CELE_T04D1.4   Protein CHD-7
Cryptosporidium hominis Chro.40182   RIKEN cDNA A730019I05 gene
Cryptosporidium parvum cgd4_1590   chromodomain-helicase-DNA-bindingmultidomain chromatin protein with the following architecture: chromo-bromo-chromo-SNF2 ATpase
Dictyostelium discoideum DDB_G0280705   CHR group protein
Drosophila melanogaster Dmel_CG3696   kismet
Echinococcus granulosus EgrG_000564800   BRK domain containing protein
Echinococcus granulosus EgrG_000512800   Chromo domain
Entamoeba histolytica EHI_115350   chromodomain-helicase-DNA-binding protein, putative
Entamoeba histolytica EHI_000780   chromodomain-helicase-DNA-binding protein, putative
Echinococcus multilocularis EmuJ_000299500  
Echinococcus multilocularis EmuJ_000515400   hypothetical protein
Echinococcus multilocularis EmuJ_000565900   hypothetical protein
Echinococcus multilocularis EmuJ_000567000   BRK domain containing protein
Echinococcus multilocularis EmuJ_000270800   BRK domain containing protein
Echinococcus multilocularis EmuJ_000402200   hypothetical protein
Echinococcus multilocularis EmuJ_000564400   BRK domain containing protein
Echinococcus multilocularis EmuJ_000271000   chromodomain helicase DNA binding protein 7
Echinococcus multilocularis EmuJ_000022400   hypothetical protein
Echinococcus multilocularis EmuJ_000563800   BRK domain containing protein
Echinococcus multilocularis EmuJ_000512800   Chromo domain
Echinococcus multilocularis EmuJ_000299900  
Echinococcus multilocularis EmuJ_000564800   BRK domain containing protein
Echinococcus multilocularis EmuJ_000026800   BRK domain containing protein
Homo sapiens ENSG00000100888   chromodomain helicase DNA binding protein 8
Homo sapiens ENSG00000177200   chromodomain helicase DNA binding protein 9
Homo sapiens ENSG00000171316   chromodomain helicase DNA binding protein 7
Homo sapiens ENSG00000124177   chromodomain helicase DNA binding protein 6
Loa Loa (eye worm) LOAG_02125   helicase
Loa Loa (eye worm) LOAG_09381   helicase DNA-binding protein
Mus musculus ENSMUSG00000053754   chromodomain helicase DNA binding protein 8
Mus musculus ENSMUSG00000056608   chromodomain helicase DNA binding protein 9
Mus musculus 102643201   chromodomain-helicase-DNA-binding protein 9-like
Mus musculus ensembl-mmu:ENSMUSG00000057133   chromodomain helicase DNA binding protein 6
Mus musculus ENSMUSG00000041235   chromodomain helicase DNA binding protein 7
Schistosoma japonicum Sjp_0006120   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma mansoni Smp_130470   hypothetical protein
Schmidtea mediterranea mk4.004621.06  
Schmidtea mediterranea mk4.004621.04  
Schmidtea mediterranea mk4.000079.09   Chromodomain-helicase-DNA-binding protein 6
Trichomonas vaginalis TVAG_035500   chromodomain helicase DNA binding protein, putative
Trichomonas vaginalis TVAG_264810   chromodomain helicase DNA binding protein, putative
Trichomonas vaginalis TVAG_382210   chromodomain helicase DNA binding protein, putative
Trichomonas vaginalis TVAG_008030   chromodomain helicase DNA binding protein, putative
Trichomonas vaginalis TVAG_302840   chromodomain helicase DNA binding protein, putative
Trichomonas vaginalis TVAG_126300   chromodomain-helicase-DNA-binding protein, putative
Trichomonas vaginalis TVAG_076520   chromodomain helicase DNA binding protein, putative
Trichomonas vaginalis TVAG_368250   chromodomain-helicase-DNA-binding protein, putative
Trichomonas vaginalis TVAG_286450   chromodomain-helicase-DNA-binding protein, putative
Trichomonas vaginalis TVAG_423310   chromodomain-helicase-DNA-binding protein, putative
Trichomonas vaginalis TVAG_308180   chromodomain-helicase-DNA-binding protein, putative
Trichomonas vaginalis TVAG_425870   chromodomain helicase DNA binding protein, putative
Trichomonas vaginalis TVAG_388280   chromodomain helicase DNA binding protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_41850 (Brugia malayi), Associated with TFs and helicases family protein
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