Detailed view for PF3D7_1321600
Basic information
Plasmodium falciparum, phosphodiesterase gamma, putative
Source Database / ID: PlasmoDB | GeneDB | MPMP
pI: 8.984 |
Length (AA): 769 |
MW (Da): 91680 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0003824 catalytic activity
GO:0007165 signal transduction
Metabolic Pathways
Structural information
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 370 | 704 | 2hd1 (A) | 184 | 506 | 25.00 | 0 | 1 | 0.84 | -1.75 |
| 383 | 691 | 1zkl (A) | 150 | 455 | 28.00 | 0 | 1 | 0.98 | -2.14 |
| 18 | 155 | 4xr7 (K) | 306 | 458 | 31.00 | 0.51 | 0.17 | 0.119354 | 2.11 |
| 289 | 731 | 4wzi (B) | 167 | 655 | 23.00 | 0 | 1 | 0.664473 | 0.11 |
| 426 | 735 | 4i15 (A) | 608 | 918 | 24.00 | 0 | 1 | 0.727521 | -1.05 |
| 428 | 731 | 1f0j (A) | 174 | 483 | 27.00 | 0.000000000055 | 1 | 0.789519 | -0.79 |
| 429 | 741 | 1taz (A) | 160 | 496 | 35.00 | 0 | 1 | 0.791922 | -0.41 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Mid 40-60% percentile | Sporozoite. | Zanghi G |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Lower 20-40% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, gametocyte, Oocyst, Ring, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Lower 0-20% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
-
PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB -
Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. -
Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. -
Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
Orthologs
Ortholog group members (OG5_163945)
| Species | Accession | Gene Product |
|---|---|---|
| Plasmodium berghei | PBANKA_1419900 | phosphodiesterase gamma, putative |
| Plasmodium falciparum | PF3D7_1321600 | phosphodiesterase gamma, putative |
| Plasmodium knowlesi | PKNH_1422200 | phosphodiesterase gamma, putative |
| Plasmodium vivax | PVX_122890 | phosphodiesterase gamma, putative |
| Plasmodium yoelii | PY01857 | calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1b |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Druggability index (range: 0 to 1): 0.5
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
- Assay for Phosphodiesterase, 3' 5'-Cyclic Nucleotide Crude Complex (3.1.4.17 ) Sigma-Aldrich
- Automatic link to known assays based on EC numbers.
Reagent availability
- Pfal004190CAG;
-
Type Source Notes soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pfal004190; Recombinant protein: truncated; Source: P falciparum; cAMP-specific 3',5'-cyclic phosphodiesterase 4B, putative ;
Bibliographic References
2 literature references were collected for this gene.