Detailed view for PF3D7_1366800

Basic information

TDR Targets ID: 255
Plasmodium falciparum, phosphatidylserine synthase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.1803 | Length (AA): 357 | MW (Da): 41979 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 9

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03034   Phosphatidyl serine synthase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016780   phosphotransferase activity, for other substituted phosphate groups  
GO:0016020   membrane  
GO:0006659   phosphatidylserine biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
248 352 4bv0 (A) 113 208 35.00 0.73 0.01 0.245018 2.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, Oocyst, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128533)

Species Accession Gene Product
Arabidopsis thaliana AT1G15110   phosphatidylserine synthase 1
Brugia malayi Bm1_15755   Phosphatidyl serine synthase family protein
Caenorhabditis elegans CELE_T27E9.5   Protein PSSY-2
Caenorhabditis elegans CELE_ZC506.3   Protein PSSY-1
Cryptosporidium hominis Chro.10133   hypothetical protein
Cryptosporidium parvum cgd1_1110   phosphatidylserine synthase I (serine-exchange enzyme I), 9x transmembrane domains
Dictyostelium discoideum DDB_G0278159   phosphatidylserine synthase
Drosophila melanogaster Dmel_CG4825   CG4825 gene product from transcript CG4825-RB
Echinococcus granulosus EgrG_000340600   phosphatidylserine synthase 1
Entamoeba histolytica EHI_009800   phosphatidylserine synthase, putative
Echinococcus multilocularis EmuJ_000340600   phosphatidylserine synthase 1
Homo sapiens ENSG00000174915   phosphatidylserine synthase 2
Homo sapiens 9791   phosphatidylserine synthase 1
Leishmania braziliensis LbrM.14.1370   phosphatidylserine synthase, putative
Leishmania donovani LdBPK_141280.1   phosphatidylserine synthase, putative
Leishmania infantum LinJ.14.1280   phosphatidylserine synthase, putative
Leishmania major LmjF.14.1200   phosphatidylserine synthase, putative
Leishmania mexicana LmxM.14.1200   phosphatidylserine synthase, putative
Loa Loa (eye worm) LOAG_03304   hypothetical protein
Mus musculus ENSMUSG00000021518   phosphatidylserine synthase 1
Mus musculus 27388   phosphatidylserine synthase 2
Neospora caninum NCLIV_026010   Phosphatidylserine synthase 2 (EC 2.7.8.-), related
Oryza sativa 4326076   Os01g0118300
Oryza sativa 9271420   Os01g0683500
Oryza sativa 4339554   Os05g0554400
Plasmodium berghei PBANKA_1142700   phosphatidylserine synthase, putative
Plasmodium falciparum PF3D7_1366800   phosphatidylserine synthase, putative
Plasmodium knowlesi PKNH_1104500   phosphatidylserine synthase, putative
Plasmodium vivax PVX_115300   phosphatidylserine synthase, putative
Plasmodium yoelii PY06104   hypothetical protein
Schistosoma japonicum Sjp_0061470   ko:K08729 phosphatidylserine synthase 1, putative
Schistosoma japonicum Sjp_0022460   ko:K08730 phosphatidylserine synthase 2, putative
Schistosoma japonicum Sjp_0022450   Phosphatidylserine synthase 2, putative
Schistosoma mansoni Smp_127890   phosphatidylserine synthase 1
Schistosoma mansoni Smp_125780   phosphatidylserine synthase 2
Schmidtea mediterranea mk4.000385.05   Phosphatidylserine synthase 1
Schmidtea mediterranea mk4.008958.00   Phosphatidylserine synthase 1
Schmidtea mediterranea mk4.010454.01   Phosphatidylserine synthase 1
Schmidtea mediterranea mk4.026614.00   Phosphatidylserine synthase 1
Schmidtea mediterranea mk4.035211.00   Phosphatidylserine synthase 1
Schmidtea mediterranea mk4.002426.04  
Schmidtea mediterranea mk4.011070.00   Phosphatidylserine synthase 1
Schmidtea mediterranea mk4.008159.01   Phosphatidylserine synthase 1
Schmidtea mediterranea mk4.002426.03   Phosphatidylserine synthase 2
Trypanosoma brucei gambiense Tbg972.7.4190   phosphatidylserine synthase, putative
Trypanosoma brucei Tb927.7.3760   phosphatidylserine synthase, putative
Trypanosoma congolense TcIL3000_7_3020   phosphatidylserine synthase, putative
Trypanosoma cruzi TcCLB.506795.40   phosphatidylserine synthase, putative
Trypanosoma cruzi TcCLB.509937.30   phosphatidylserine synthase, putative
Toxoplasma gondii TGME49_261480   phosphatidyl serine synthase

Essentiality

PF3D7_1366800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3760 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.3760 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.3760 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.3760 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_261480 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

6 literature references were collected for this gene.

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Gene identifier PF3D7_1366800 (Plasmodium falciparum), phosphatidylserine synthase, putative
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