pI: 4.813 |
Length (AA): 848 |
MW (Da): 93175 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 848 | 1qvr (A) | 4 | 847 | 52.00 | 0 | 1 | 1.49326 | -0.01 |
159 | 343 | 2p65 (A) | 3 | 187 | 70.00 | 0 | 1 | 1.20716 | -1.95 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126636)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G25140 | casein lytic proteinase B4 |
Arabidopsis thaliana | AT5G50920 | ATP-dependent Clp protease ATP-binding subunit ClpC |
Arabidopsis thaliana | AT3G48870 | Clp ATPase |
Arabidopsis thaliana | AT4G14670 | hypothetical protein |
Arabidopsis thaliana | AT1G74310 | chaperone protein ClpB1 |
Arabidopsis thaliana | AT5G51070 | chaperone protein ClpD |
Arabidopsis thaliana | AT5G15450 | chaperone protein ClpB3 |
Babesia bovis | BBOV_III008980 | Clp amino terminal domain containing protein |
Babesia bovis | BBOV_II004100 | ClpB, putative |
Candida albicans | CaO19.884 | similar to S. cerevisiae HSP78 (YDR258C) involved in folding of some mitochondrial proteins |
Candida albicans | CaO19.13747 | heat shock protein 104 |
Candida albicans | CaO19.8503 | similar to S. cerevisiae HSP78 (YDR258C) involved in folding of some mitochondrial proteins |
Cryptosporidium hominis | Chro.70298 | clpB protein |
Cryptosporidium parvum | cgd7_2620 | ClpB ATpase (bacterial), signal peptide |
Chlamydia trachomatis | CT_286 | ATP-dependent Clp protease ATP-binding subunit ClpC |
Chlamydia trachomatis | CT_113 | chaperone protein ClpB |
Dictyostelium discoideum | DDB_G0289047 | AAA ATPase domain-containing protein |
Dictyostelium discoideum | DDB_G0291314 | AAA ATPase domain-containing protein |
Escherichia coli | b2592 | protein disaggregation chaperone |
Entamoeba histolytica | EHI_156560 | heat shock protein, putative |
Entamoeba histolytica | EHI_028920 | heat shock protein, putative |
Entamoeba histolytica | EHI_034710 | heat shock protein, putative |
Entamoeba histolytica | EHI_022620 | heat shock protein, putative |
Entamoeba histolytica | EHI_005657 | hypothetical protein |
Entamoeba histolytica | EHI_072140 | heat shock protein, putative |
Entamoeba histolytica | EHI_017350 | heat shock protein, putative |
Entamoeba histolytica | EHI_183680 | heat shock protein 101, putative |
Entamoeba histolytica | EHI_042860 | heat shock protein, putative |
Giardia lamblia | GL50803_17520 | ClpB protein |
Homo sapiens | ENSG00000162129 | ClpB caseinolytic peptidase B homolog (E. coli) |
Leishmania braziliensis | LbrM.29.1350 | ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative,serine peptidase, putative |
Leishmania braziliensis | LbrM.27.2750 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative,serine peptidase, putative |
Leishmania donovani | LdBPK_291360.1 | ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative |
Leishmania donovani | LdBPK_020680.1 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative |
Leishmania infantum | LinJ.29.1360 | ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative,serine peptidase, putative |
Leishmania infantum | LinJ.02.0680 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative,serine peptidase, putative |
Leishmania major | LmjF.27.2630 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative,serine peptidase, putative |
Leishmania major | LmjF.02.0710 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative,serine peptidase, putative |
Leishmania major | LmjF.29.1270 | ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative,serine peptidase, putative |
Leishmania mexicana | LmxM.02.0710 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative,serine peptidase, putative |
Leishmania mexicana | LmxM.08_29.1270 | ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative,serine peptidase, putative |
Mycobacterium leprae | ML2490c | PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1) |
Mycobacterium leprae | ML0235 | Probable ATP-dependent Clp protease ATP-binding subunit ClpC |
Mus musculus | ENSMUSG00000001829 | ClpB caseinolytic peptidase B |
Mycobacterium tuberculosis | Rv3596c | Probable ATP-dependent protease ATP-binding subunit ClpC1 |
Mycobacterium tuberculosis | Rv0384c | Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1) |
Mycobacterium ulcerans | MUL_0127 | endopeptidase ATP binding protein (chain B) ClpB |
Mycobacterium ulcerans | MUL_4178 | ATP-dependent protease ATP-binding subunit ClpC1 |
Neospora caninum | NCLIV_028370 | hypothetical protein |
Neospora caninum | NCLIV_022360 | ATP-dependent Clp protease ATP-binding subunit clpC homolog, chloroplastic (Precursor), related |
Neospora caninum | NCLIV_037700 | hypothetical protein |
Neospora caninum | NCLIV_007220 | hypothetical protein |
Neospora caninum | NCLIV_023810 | ATP-dependent chaperone ClpB, related |
Oryza sativa | 4335702 | Os04g0397100 |
Oryza sativa | 4328515 | Os02g0181900 |
Oryza sativa | 4329520 | Os02g0526400 |
Oryza sativa | 4339343 | Os05g0519700 |
Oryza sativa | 4333161 | Os03g0426900 |
Oryza sativa | 4350258 | Os11g0267400 |
Oryza sativa | 4351828 | Os12g0230100 |
Plasmodium berghei | PBANKA_0931200 | heat shock protein 101 |
Plasmodium berghei | PBANKA_0714200 | chaperone protein ClpB1, putative |
Plasmodium falciparum | PF3D7_1116800 | heat shock protein 101 |
Plasmodium falciparum | PF3D7_0816600 | chaperone protein ClpB1 |
Plasmodium knowlesi | PKNH_0503800 | chaperone protein ClpB1, putative |
Plasmodium knowlesi | PKNH_0914500 | heat shock protein 101, putative |
Plasmodium vivax | PVX_091470 | heat shock protein 101, putative |
Plasmodium vivax | PVX_089580 | chaperone protein ClpB1, putative |
Plasmodium yoelii | PY00565 | ClpB protein |
Plasmodium yoelii | PY05364 | clpB protein |
Saccharomyces cerevisiae | YDR258C | chaperone ATPase HSP78 |
Saccharomyces cerevisiae | YLL026W | chaperone ATPase HSP104 |
Schistosoma japonicum | Sjp_0300960 | ko:K03695 ATP-dependent Clp protease ATP-binding subunit ClpB, putative |
Schistosoma mansoni | Smp_145990 | suppressor of potassium transport defect 3 (skd3 protein) |
Schmidtea mediterranea | mk4.024118.00 | Caseinolytic peptidase B protein homolog |
Schmidtea mediterranea | mk4.002488.00 | |
Schmidtea mediterranea | mk4.028771.00 | Caseinolytic peptidase B protein homolog |
Trypanosoma brucei gambiense | Tbg.972.2.1440 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative,serine peptidase, putative |
Trypanosoma brucei gambiense | Tbg.972.2.4200 | ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative,serine peptidase, putative |
Trypanosoma brucei | Tb927.2.3030 | ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative |
Trypanosoma brucei | Tb927.2.5980 | chaperone protein ClpB1, putative |
Trypanosoma congolense | TcIL3000_2_1650 | chaperone protein ClpB1, putative |
Trypanosoma congolense | TcIL3000_2_1630 | chaperone protein ClpB1, putative |
Trypanosoma congolense | TcIL3000_2_370 | serine peptidase, putative |
Trypanosoma cruzi | TcCLB.508665.14 | chaperone protein ClpB1, putative |
Trypanosoma cruzi | TcCLB.509125.20 | ATP-dependent Clp protease subunit, heat shock protein 78, putative |
Trypanosoma cruzi | TcCLB.508737.100 | ATP-dependent Clp protease subunit, heat shock protein 78, putative |
Toxoplasma gondii | TGME49_268650 | chaperone clpB protein, putative |
Toxoplasma gondii | TGME49_282200 | ATPase, AAA family protein |
Toxoplasma gondii | TGME49_202580 | ATPase, AAA family protein |
Toxoplasma gondii | TGME49_275690 | ClpB, putative |
Treponema pallidum | TP0071 | ATP-dependent Clp protease subunit B (clpB) |
Treponema pallidum | TP0549 | ATPase (clpC) |
Theileria parva | TP04_0174 | ClpB protein, putative |
Theileria parva | TP04_0800 | ATP-dependent Clp protease ATP-binding subunit, putative |
Trichomonas vaginalis | TVAG_365820 | conserved hypothetical protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0181 | ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3658 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.2.5980 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.5980 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.5980 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.5980 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.2.3030 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.3030 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.3030 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.3030 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2592 | Escherichia coli | non-essential | goodall |
PBANKA_0714200 | Plasmodium berghei | Essential | plasmo |
PBANKA_0931200 | Plasmodium berghei | Essential | plasmo |
TGME49_268650 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_275690 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_202580 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_282200 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_268650 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_275690 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_202580 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_282200 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_268650 | Toxoplasma gondii | Probably essential | sidik |
TGME49_275690 | Toxoplasma gondii | Probably essential | sidik |
TGME49_202580 | Toxoplasma gondii | Probably essential | sidik |
TGME49_282200 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.