TDR Targets

Detailed view for ML0101

Basic information

TDR Targets ID: 257161
Mycobacterium leprae, Polyketide synthase Pks13
Source Database / ID: Leproma

pI: 4.5969 | Length (AA): 1784 | MW (Da): 192781 | Paralog Number: 8

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Network

Pfam domains

PF00109 Beta-ketoacyl synthase, N-terminal domain
PF00550 Phosphopantetheine attachment site
PF00698 Acyl transferase domain
PF00975 Thioesterase domain
PF02801 Beta-ketoacyl synthase, C-terminal domain
PF16197 Ketoacyl-synthetase C-terminal extension

Gene Ontology

Mouse over links to read term descriptions.

GO:0031177 phosphopantetheine binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0005488 binding
GO:0003824 catalytic activity
GO:0000036 acyl carrier activity
GO:0048037 cofactor binding
GO:0016740 transferase activity
GO:0008152 metabolic process
GO:0009058 biosynthetic process

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg	Target End	Template	Template Beg	Template End	Identity	Model Score	MPQS	zDope
1	600	2uv8 (A)	940	1684	17.00	1	0.201423	0.58
52	128	6c4q (A)	19	95	90.00	1	1.25326	-2.23
149	577	4z37 (A)	2320	2761	39.00	1	0.732571	-0.75
151	1550	2vz8 (A)	3	1413	25.00	1	0.872853	0.85
152	645	4qyr (A)	2547	3041	43.00	1	0.680006	-0.06
195	1700	2vz8 (A)	36	1567	22.00	1	0.92507	1.21
628	1091	3tzy (A)	596	1059	87.00	1	1.35019	-1.33
1193	1771	4zxh (A)	754	1313	18.00	1	0.413452	0.83
1417	1497	6c4v (A)	1370	1450	84.00	1	1.1875	-2.15
1498	1780	5v3w (A)	1451	1726	89.00	1	1.27873	-1.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126633)

Species	Accession	Gene Product
Brugia malayi	Bm1_08575	Beta-ketoacyl synthase, N-terminal domain containing protein
Brugia malayi	Bm1_35180	oxidoreductase, zinc-binding dehydrogenase family protein
Caenorhabditis elegans	CELE_F32H2.5	Protein FASN-1
Cryptosporidium hominis	Chro.30258	hypothetical protein
Cryptosporidium hominis	Chro.40330	hypothetical protein
Cryptosporidium parvum	cgd4_2900	polyketide synthase
Cryptosporidium parvum	cgd3_2180	type I fatty acid synthase
Dictyostelium discoideum	DDB_G0281475	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0284001	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0271000	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0271614	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0291684	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290703	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0271530	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0288457	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0275077	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0291614	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0271618	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0271524	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290709	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0293912	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290729	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0295667	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0272981	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0275069	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0283931	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290943	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0271662	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290853	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290701	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290469	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0269364	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0270572	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0287095	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0291604	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0273007	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290937	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0282029	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0272859	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0282027	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0287119	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0292544	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0295659	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0293902	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290467	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290699	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0271520	beta-ketoacyl synthase family protein
Dictyostelium discoideum	DDB_G0290737	beta-ketoacyl synthase family protein
Drosophila melanogaster	Dmel_CG3523	CG3523 gene product from transcript CG3523-RA
Drosophila melanogaster	Dmel_CG17374	CG17374 gene product from transcript CG17374-RC
Drosophila melanogaster	Dmel_CG3524	CG3524 gene product from transcript CG3524-RB
Homo sapiens	ENSG00000169710	fatty acid synthase
Loa Loa (eye worm)	LOAG_12875	acyl carrier protein
Loa Loa (eye worm)	LOAG_12856	hypothetical protein
Loa Loa (eye worm)	LOAG_05412	fatty acid synthase
Loa Loa (eye worm)	LOAG_06344	hypothetical protein
Loa Loa (eye worm)	LOAG_05695	hypothetical protein
Mycobacterium leprae	ML2353c	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE
Mycobacterium leprae	ML2356c	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB
Mycobacterium leprae	ML1229	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4
Mycobacterium leprae	ML2357c	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA
Mycobacterium leprae	ML2354c	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD
Mycobacterium leprae	ML0101	Polyketide synthase Pks13
Mycobacterium leprae	ML0139	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas
Mycobacterium leprae	ML2355c	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC
Mycobacterium leprae	ML0135	Probable polyketide synthase Pks1
Mus musculus	ENSMUSG00000025153	fatty acid synthase
Mycobacterium tuberculosis	Rv2931	Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Mycobacterium tuberculosis	Rv2933	Phenolpthiocerol synthesis type-I polyketide synthase PpsC
Mycobacterium tuberculosis	Rv2934	Phenolpthiocerol synthesis type-I polyketide synthase PpsD
Mycobacterium tuberculosis	Rv2940c	Probable multifunctional mycocerosic acid synthase membrane-associated Mas
Mycobacterium tuberculosis	Rv1527c	Probable polyketide synthase Pks5
Mycobacterium tuberculosis	Rv1180	Probable polyketide beta-ketoacyl synthase Pks3
Mycobacterium tuberculosis	Rv1181	Probable polyketide beta-ketoacyl synthase Pks4
Mycobacterium tuberculosis	Rv2048c	Polyketide synthase Pks12
Mycobacterium tuberculosis	Rv3800c	Polyketide synthase Pks13
Mycobacterium tuberculosis	Rv0405	Probable membrane bound polyketide synthase Pks6
Mycobacterium tuberculosis	Rv1661	Probable polyketide synthase Pks7
Mycobacterium tuberculosis	Rv1662	Probable polyketide synthase Pks8
Mycobacterium tuberculosis	Rv2935	Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Mycobacterium tuberculosis	Rv2932	Phenolpthiocerol synthesis type-I polyketide synthase PpsB
Mycobacterium tuberculosis	Rv1664	Probable polyketide synthase Pks9
Mycobacterium tuberculosis	Rv2947c	Probable polyketide synthase Pks15
Mycobacterium tuberculosis	Rv2946c	Probable polyketide synthase Pks1
Mycobacterium tuberculosis	Rv3825c	Polyketide synthase Pks2
Mycobacterium ulcerans	MUP039c	Type I modular polyketide synthase
Mycobacterium ulcerans	MUL_2018	phenolpthiocerol synthesis type-I polyketide synthase PpsB
Mycobacterium ulcerans	MUP040c	Type I modular polyketide synthase
Mycobacterium ulcerans	MUL_2005	polyketide synthase
Mycobacterium ulcerans	MUL_1655	polyketide synthase Pks9
Mycobacterium ulcerans	MUL_2016	phenolpthiocerol synthesis type-I polyketide synthase PpsD
Mycobacterium ulcerans	MUL_2010	multifunctional mycocerosic acid synthase membrane-associated Mas
Mycobacterium ulcerans	MUL_2015	phenolpthiocerol synthesis type-I polyketide synthase PpsE
Mycobacterium ulcerans	MUP032c	Type I modular polyketide synthase
Mycobacterium ulcerans	MUL_2266	polyketide synthase
Mycobacterium ulcerans	MUL_2019	phenolpthiocerol synthesis type-I polyketide synthase PpsA
Mycobacterium ulcerans	MUL_4983	polyketide synthase Pks13
Mycobacterium ulcerans	MUL_2017	phenolpthiocerol synthesis type-I polyketide synthase PpsC
Neospora caninum	NCLIV_001690	Short-chain dehydrogenase/reductase SDR, related
Neospora caninum	NCLIV_020690	Soraphen polyketide synthase A, related
Neospora caninum	NCLIV_050890	KR domain domain-containing protein, putative
Onchocerca volvulus	OVOC1839
Onchocerca volvulus	OVOC5784	Fatty acid synthase homolog
Schmidtea mediterranea	mk4.052433.01
Toxoplasma gondii	TGME49_294820	type I fatty acid synthase, putative
Toxoplasma gondii	TGME49_204560	type I fatty acid synthase, putative
Toxoplasma gondii	TGME49_326200	type I fatty acid synthase
Toxoplasma gondii	TGME49_236990	beta-ketoacyl synthase, N-terminal domain-containing protein
Toxoplasma gondii	TGME49_236980	AMP-binding enzyme domain-containing protein

Essentiality

ML0101 has one or more orthologs with essentiality data

Gene/Ortholog	Organism	Phenotype	Source Study
mtu2988	Mycobacterium tuberculosis	non-essential	nmpdr
mtu3867	Mycobacterium tuberculosis	essential	nmpdr
mtu408	Mycobacterium tuberculosis	non-essential	nmpdr
mtu1690	Mycobacterium tuberculosis	essential	nmpdr
mtu1691	Mycobacterium tuberculosis	essential	nmpdr
mtu2981	Mycobacterium tuberculosis	non-essential	nmpdr
CELE_F32H2.5	Caenorhabditis elegans	embryonic arrest	wormbase
CELE_F32H2.5	Caenorhabditis elegans	embryonic lethal	wormbase
CELE_F32H2.5	Caenorhabditis elegans	larval arrest	wormbase
CELE_F32H2.5	Caenorhabditis elegans	sterile	wormbase
TGME49_294820	Toxoplasma gondii	Essentiality uncertain	sidik
TGME49_204560	Toxoplasma gondii	Essentiality uncertain	sidik
TGME49_236990	Toxoplasma gondii	Essentiality uncertain	sidik
TGME49_236980	Toxoplasma gondii	Essentiality uncertain	sidik
TGME49_326200	Toxoplasma gondii	Essentiality uncertain	sidik
TGME49_294820	Toxoplasma gondii	Probably non-essential	sidik
TGME49_204560	Toxoplasma gondii	Probably non-essential	sidik
TGME49_236990	Toxoplasma gondii	Probably non-essential	sidik
TGME49_236980	Toxoplasma gondii	Probably non-essential	sidik
TGME49_326200	Toxoplasma gondii	Probably non-essential	sidik

Show/Hide essentiality data references

shigen

Profiling of E. coli Chromosome (PEC)

National Institute of Genetics, Japan

neb

C. elegans RNAi phenotypes

Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

plasmo

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

blattner

Systematic mutagenesis of the E. coli (MG1655) genome

J Bacteriol 2004, 186:4921-4930

yeastgenome

Systematic deletion of yeast genes

Saccharomyces Genome Database

goodall

The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis)

Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

alsford

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

Genome Res 2011, 21:915-924

wormbase

C. elegans RNAi experiments

WormBase web site, http://www.wormbase.org, release WS170

gerdes

Experimental determination and system-level analysis of essential genes in E. coli MG1655

Gerdes et al., J Bacteriol. 2003 185:5673-84

keio

Systematic single-gene knock-out mutants of E. coli K12

The Keio Collection

nmpdr

Genome-scale essentiality datasets from published studies (M. tuberculosis)

National Microbial Pathogen Data Resource

sidik

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.

Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity	Phenotypic quality	Occurs in	Occurs at	Evidence	Observed in	Drugs/Inhibitors
growth (GO:0040007)	lethal (sensu genetics) (PATO:0000718)			inferred from in-silico analysis (ECO:0000043)	Mycobacterium tuberculosis	No drug identifiers listed for this gene.
Annotator:	crowther@u.washington.edu.	Comment:	2007-12-07.		References:	16261191

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets

Species	Known druggable target	Linked compounds	Reference
Gallus gallus	Fatty acid synthase	Compounds	References
Rattus norvegicus	Fatty acid synthase	Compounds	References
Homo sapiens	fatty acid synthase	Compounds	References
Mus musculus	fatty acid synthase	Compounds	References

By sequence similarity to non orthologous druggable targets

Species	Target	Length	Identity	Alignment span	Linked Drugs	Reference
Staphylococcus aureus	3-oxoacyl-[acyl-carrier-protein] synthase 2	403 aa	27.7%	358 aa	Compounds	References

Ranking Plot

Putative Drugs List

Raw	Global	Species
0.004	0.2645	1
0.213	0.7699	1
0.0045	0.6938	1
0.0085	0.2881	1
0.0045	0.3079	1
0.0038	0.4175	0.4175
0.0895	0.32	1
0.1459	0.5056	1
0.0485	0.7502	1
0.0152	0.7476	1
0.0081	0.2597	1
0.0045	0.6992	1
0.0835	0.7458	1
0.0512	0.7721	1
0.0045	0.2987	1
0.0231	0.2525	1
0.035	0.4303	1
0.0522	0.3462	1
0.0045	0.7476	1
0.0071	0.2948	0
0.1048	0.7799	1
0.0946	0.6993	1
0.0115	0.3243	0
0.0114	0.2505	1
0.0129	0.7417	1
0.0045	0.6992	1
0.0043	0.3172	1
0.0584	0.7476	1
0.057	0.7754	1
0.2106	0.7845	1
0.0045	0.7461	1
0.0077	0.7465	1
0.0074	0.3881	1
0.0036	0.4114	0.4035
0.0188	0.7476	1
0.1151	0.7766	1
0.098	0.6049	1
0.1999	0.784	1
0.0349	0.6908	1
0.0045	0.7476	1
0.0936	0.7851	1
0.1099	0.7425	1
0.1001	0.7426	1
0.0972	0.3893	1
0.0045	0.7476	1
0.0045	0.7476	1
0.1109	0.7862	1
0.0045	0.7476	1
0.1642	0.7476	1
0.0079	0.7476	1
0.1038	0.6333	1
0.011	0.5013	1
0.2128	0.7816	1
0.1779	0.7486	1
0.1287	0.7426	1
0.1973	0.7875	1
0.0075	0.7476	1
0.0381	0.4722	1
0.01	0.3212	0
0.0045	0.2645	1
0.0197	0.7498	1
0.0045	0.5292	1
0.0168	0.4446	1
0.0037	0.2634	1
0.0943	0.7504	1
0.1904	0.7812	1
0.0271	0.3218	1
0.0976	0.5937	1
0.1022	0.747	1
0.0068	0.2643	1
0.0205	0.7465	1
0.0725	0.7791	1
0.0045	0.7476	1
0.0122	0.3398	1
0.0045	0.7476	1
0.0045	0.5229	1
0.0986	0.7166	1
0.0037	0.2573	1
0.0045	0.6992	1
0.0271	0.319	1
0.0091	0.7407	1
0.1642	0.7476	1
0.1236	0.7793	1
0.0045	0.7476	1
0.1026	0.7771	1
0.0112	0.7476	1
0.1829	0.7572	1
0.0367	0.7365	1
0.0091	0.7396	1
0.0934	0.3746	1
0.0207	0.7465	1
0.0748	0.7476	1
0.0045	0.7476	1
0.0037	0.7417	1
0.0045	0.7476	1
0.0877	0.7469	1
0.0121	0.3697	1
0.0045	0.7476	1
0.0533	0.7476	1
0.0045	0.7465	1
0.1459	0.5056	1
0.0039	0.4175	0.4175
0.0081	0.7417	1
0.0199	0.7486	1
0.0086	0.733	1
0.0045	0.7486	1
0.1642	0.7476	1
0.0037	0.2562	1
0.0895	0.32	1
0.0045	0.7476	1
0.1346	0.781	1
0.0045	0.7476	1
0.0045	0.5306	1
0.0036	0.7312	1
0.5181	0.7877	1
0.0045	0.7476	1
0.1264	0.747	1
0.1015	0.7868	1
0.0042	0.7417	1
0.094	0.5643	1
0.0045	0.6822	1
0.0431	0.7638	1
0.0045	0.7465	1
0.0083	0.7476	1
0.1189	0.7486	1
0.0091	0.4118	1
0.0045	0.2514	1
0.0076	0.7465	1
0.0039	0.7486	1
0.0225	0.7447	1
0.5254	0.3223	1
0.1368	0.4869	1
0.1395	0.7486	1
0.025	0.7465	1
0.118	0.7422	1
0.0045	0.4207	1
0.0159	0.3631	1
0.0112	0.7476	1
0.1031	0.7872	1
0.0436	0.7695	1
0.2012	0.2577	1
0.0355	0.6289	1
0.0085	0.7465	1
0.0239	0.7476	1
0.1681	0.7424	1
0.1599	0.7709	1
0.1739	0.7465	1
0.0126	0.733	1
0.0045	0.7019	1
0.0813	0.6914	1
0.0079	0.3727	1
0.0934	0.7477	1
0.1527	0.7486	1
0.5784	0.7875	1
0.0659	0.7467	1
0.0045	0.2913	0.2913
0.0037	0.7486	1
0.0045	0.7476	1
0.086	0.7476	1
0.0045	0.7476	1
0.0051	0.251	0.1992
0.0045	0.5292	1
0.0045	0.7476	1
0.008	0.5349	1
0.028	0.7312	1
0.1459	0.5056	1
0.109	0.7428	1
0.0184	0.7712	1
0.0125	0.2648	1
0.1642	0.7476	1
0.004	0.6992	1
0.1503	0.7726	1
0.0045	0.2645	1
0.12	0.7806	1
0.0859	0.7426	1
0.103	0.7869	1
0.0045	0.6813	1
0.0082	0.7465	1
0.1395	0.7486	1
0.0039	0.7465	1
0.1627	0.7839	1
0.0045	0.7476	1
0.1487	0.4678	1
0.0082	0.7417	1
0.0675	0.7486	1
0.0045	0.7476	1
0.0045	0.3538	1
0.0045	0.2655	1
0.0843	0.7862	1
0.0151	0.7476	1
0.0045	0.7465	1
0.0045	0.2645	1
0.0112	0.5222	1
0.1048	0.7799	1
0.0151	0.7476	1
0.0045	0.5582	1
0.1405	0.7866	1
0.0471	0.7547	1
0.0936	0.7851	1
0.1487	0.4678	1
0.0248	0.7712	1
0.0036	0.2645	1
0.0972	0.752	1
0.0453	0.5558	1
0.1572	0.754	1
0.0045	0.3714	1
0.0043	0.7486	1
0.0077	0.7407	1
0.1262	0.747	1
0.0037	0.7486	1
0.1487	0.468	1
0.0224	0.7476	1
0.0117	0.7476	1
0.1006	0.7486	1
0.09	0.7486	1
0.0045	0.7465	1
0.3205	0.787	1
0.1265	0.7424	1
0.0693	0.338	1
0.0122	0.3398	1
0.0297	0.7476	1
0.0481	0.7465	1
0.0787	0.2559	0.2548
0.0936	0.7851	1
0.0167	0.2878	1
0.0045	0.7465	1
0.1015	0.7868	1
0.0045	0.7476	1
0.1048	0.7799	1
0.0045	0.7476	1
0.0337	0.749	1
0.0152	0.7476	1
0.0453	0.5558	1
0.1203	0.7476	1
0.0633	0.7428	1
0.0045	0.7465	1
0.0333	0.7312	1
0.2012	0.2577	1
0.0045	0.7476	1
0.0045	0.7476	1
0.0816	0.7855	1
0.0242	0.7486	1
0.0078	0.356	0.356
0.098	0.7792	1
0.1356	0.5176	1
0.0635	0.7486	1
0.0131	0.2617	1
0.0045	0.7476	1
0.0045	0.5582	1
0.0988	0.6055	1
0.0045	0.7476	1
0.0045	0.7476	1
0.0238	0.3582	1
0.1346	0.781	1
0.0045	0.3012	1
0.0308	0.7831	1
0.0045	0.7486	1
0.0428	0.7725	1
0.468	0.3412	1
0.2082	0.7826	1
0.0642	0.6138	1
0.0803	0.588	1
0.0039	0.7486	1
0.02	0.7562	1
0.073	0.7433	1
0.0045	0.4341	1
0.0091	0.7407	1
0.0045	0.5306	1
0.0803	0.588	1
0.0249	0.4346	1
0.6252	0.7878	1
0.0045	0.2645	0.4175
0.0522	0.3462	1
0.0704	0.7207	1
0.0869	0.7486	1
0.0045	0.7476	1
0.0045	0.7476	1
0.0037	0.7417	1
0.0045	0.7476	1
0.0045	0.7465	1
0.0045	0.2645	1
0.1527	0.7486	1
0.1346	0.781	1
0.0612	0.7843	1
0.1329	0.7486	1
0.008	0.284	1
0.0232	0.2699	0.2699
0.0172	0.3005	1
0.0569	0.7486	1
0.1607	0.7323	1
0.0531	0.7476	1
0.0977	0.3848	1
0.0043	0.7486	1
0.0045	0.5094	1
0.0752	0.7457	1
0.0045	0.7465	1
0.0077	0.2928	1
0.0122	0.3398	1
0.1092	0.7766	1
0.0195	0.7476	1
0.0045	0.4301	1
0.0991	0.7486	1
0.0045	0.7476	1
0.0659	0.7476	1
0.0126	0.2995	1
0.0045	0.7465	1
0.0159	0.2641	1
0.0045	0.6534	1
0.0122	0.3398	1
0.057	0.7754	1
0.0232	0.7522	1
0.0237	0.7356	1
0.0311	0.4679	1
0.0045	0.7476	1
0.0045	0.6992	1
0.0229	0.7476	1
0.0936	0.7851	1
0.0199	0.7417	1
0.0985	0.3546	1
0.0045	0.2645	1
0.0045	0.7476	1
0.0232	0.2699	0.2699
0.1607	0.7323	1
0.0387	0.7572	1
0.0161	0.7486	1
0.0122	0.3398	1
0.0041	0.2634	1
0.0045	0.7476	1
0.0642	0.7486	1
0.0238	0.7486	1
0.0169	0.2579	1
0.0479	0.7463	1
0.3208	0.5502	1
0.0292	0.3397	1
0.0073	0.2865	1
0.0112	0.3864	1
0.0045	0.7476	1
0.0083	0.7407	1
0.0247	0.3779	1
0.0045	0.7465	1
0.0522	0.3462	1
0.6658	0.7878	1
0.0045	0.7412	1
0.1161	0.7872	1
0.0936	0.7851	1
0.0045	0.7476	1
0.0087	0.7465	1
0.0727	0.7862	1
0.0045	0.7476	1
0.0096	0.7417	1
0.2128	0.7816	1
0.0042	0.4103	1
0.0543	0.3307	1
0.0129	0.7476	1
0.0155	0.733	1
0.0813	0.6914	1
0.0956	0.7647	1
0.0091	0.3832	1
0.0992	0.7486	1
0.1999	0.784	1
0.0479	0.7463	1
0.2077	0.7718	1
0.0787	0.2559	0.2548
0.0045	0.7476	1
0.0231	0.7572	1
0.0045	0.7476	1
0.0122	0.3398	1
0.0045	0.3028	1
0.0091	0.7407	1
0.0196	0.6824	1
0.2058	0.7572	1
0.1363	0.7587	1
0.1572	0.754	1
0.0097	0.3189	0.4485
0.1053	0.6566	1
0.0784	0.7476	1
0.6158	0.7874	1
0.0112	0.7476	1
0.113	0.7426	1
0.0024	0.7465	1
0.0194	0.7476	1
0.0045	0.7476	1
0.0045	0.7476	1
0.0122	0.3398	1
0.0045	0.7476	1
0.0231	0.2525	1
0.6158	0.7874	1
0.0976	0.5937	1
0.1186	0.4181	1
0.191	0.7562	1
0.0972	0.3893	1
0.0045	0.4509	1
0.1069	0.7826	1
0.0612	0.7843	1
0.0045	0.3143	1
0.0091	0.7407	1
0.1053	0.6566	1
0.0043	0.4614	1
0.0087	0.7476	1
0.0045	0.4312	1
0.0872	0.2538	1
0.0196	0.7465	1
0.0847	0.7562	1
0.1074	0.7762	1
0.0045	0.7465	1
0.0045	0.7476	1
0.004	0.2527	1
0.0045	0.6777	1
0.0158	0.7465	1
0.0524	0.7486	1
0.0045	0.7476	1
0.0045	0.4409	1
0.0044	0.2683	1
0.0415	0.7476	1
0.0045	0.7476	1
0.035	0.4303	1
0.1605	0.4773	1
0.0045	0.7476	1
0.061	0.2639	1
0.0297	0.3471	1
0.1092	0.7766	1
0.0129	0.3748	1
0.0045	0.7476	1
0.0114	0.7476	1
0.0045	0.7476	1
0.0984	0.3942	1
0.625	0.7777	1
0.0045	0.7465	1
0.0082	0.2743	1
0.0126	0.2995	1
0.1288	0.7425	1
0.1432	0.7476	1
0.0316	0.3673	1
0.098	0.7792	1
0.0803	0.588	1
0.0189	0.3767	1
0.0045	0.7476	1
0.0044	0.7312	1
0.057	0.7754	1
0.0484	0.5042	1
0.1642	0.7476	1
0.6158	0.7874	1
0.0043	0.3404	1
0.0862	0.5079	1
0.1772	0.7853	1
0.0045	0.5292	1
0.0091	0.7407	1
0.0045	0.7476	1
0.0345	0.7486	1
0.0155	0.2975	1
0.0827	0.6018	1
0.6158	0.7874	1
0.1599	0.7709	1
0.0045	0.7465	1
0.1999	0.784	1
0.0416	0.746	1
0.0045	0.5763	1
0.0045	0.7476	1
0.0585	0.6041	1
0.2012	0.2577	1
0.0045	0.7417	1
0.0045	0.7476	1
0.0045	0.747	1
0.0221	0.2519	1
0.0045	0.7476	1
0.0045	0.7476	1
0.0091	0.7407	1
0.0334	0.3448	1
0.0037	0.2573	1
0.0926	0.787	1
0.0045	0.7476	1
0.0078	0.7476	1
0.1205	0.747	1
0.0045	0.2634	1
0.1186	0.3114	1
0.1004	0.7476	1
0.027	0.7712	1
0.0803	0.588	1
0.1968	0.7572	1
0.068	0.7548	1
0.0126	0.2643	1
0.0045	0.7476	1
0.0045	0.7465	1
0.2058	0.7572	1
0.0961	0.7424	1
0.1476	0.7465	1
0.0206	0.3072	1
0.0045	0.6992	1
0.0248	0.7712	1
0.1482	0.7572	1
0.0081	0.3836	1
0.0045	0.6822	1
0.0832	0.7812	1
0.0045	0.7476	1
0.0045	0.7476	1
0.0296	0.7653	1
0.0112	0.4348	1
0.0045	0.7416	1
0.0245	0.7417	1
0.2237	0.7837	1
0.0306	0.3517	1
0.0045	0.2751	1
0.0684	0.7486	1
0.0149	0.7486	1
0.0045	0.667	1
0.0045	0.7476	1
0.0045	0.6836	1
0.0456	0.7486	1
0.0045	0.7476	1
0.1346	0.781	1
0.028	0.7312	1
0.0306	0.3397	1
0.0122	0.3398	1
0.1627	0.7839	1
0.1419	0.7476	1
0.098	0.3561	1
0.1871	0.7874	1
0.1722	0.7562	1
0.0045	0.7476	1
0.1573	0.7486	1
0.0953	0.4481	1
0.0155	0.2975	1
0.0042	0.279	1
0.0045	0.5292	1
0.0045	0.7312	1
0.0045	0.7476	1
0.02	0.7476	1
0.0045	0.7476	1
0.0045	0.7476	1
0.0126	0.3383	1
0.0045	0.7474	1
0.0259	0.3933	1
0.0121	0.4077	1
0.1973	0.7875	1
0.049	0.7476	1
0.1681	0.7424	1
0.0045	0.7476	1
0.0045	0.5785	1
0.134	0.7426	1
0.0803	0.588	1
0.0493	0.7463	1
0.0244	0.7562	1
0.1739	0.7465	1
0.0251	0.7045	1
0.1015	0.7868	1
0.0045	0.7476	1
0.0076	0.3424	0.3424
0.0045	0.6992	1
0.0803	0.588	1
0.0077	0.7465	1
0.0752	0.7457	1
0.0045	0.2634	1
0.0847	0.7469	1
0.0312	0.2768	1
0.1607	0.7323	1
0.015	0.2638	1
0.0045	0.6992	1
0.0115	0.5042	1
0.0045	0.7476	1
0.0754	0.7444	1
0.0276	0.7562	1
0.1519	0.7486	1
0.0045	0.7476	1
0.0152	0.7476	1
0.012	0.3271	1
0.0045	0.7476	1
0.0045	0.6942	1
0.1015	0.7868	1
0.0126	0.3383	1
0.0045	0.7476	1
0.0091	0.7407	1
0.0045	0.7465	1
0.076	0.7427	1
0.0038	0.5867	1
0.1028	0.747	1
0.0052	0.733	1
0.0045	0.7312	1
0.0045	0.7476	1
0.0752	0.7784	1
0.0122	0.3398	1
0.0045	0.6931	1
0.0045	0.7476	1
0.0045	0.6938	1
0.0036	0.4297	0.6231
0.0026	0.7465	1
0.0612	0.7843	1
0.145	0.7765	1
0.0936	0.7851	1
0.5849	0.7873	1
0.2237	0.7837	1
0.0045	0.7476	1
0.0111	0.7486	1
0.0036	0.5452	1
0.0045	0.7476	1
0.7259	0.3456	1
0.172	0.7572	1
0.0045	0.7476	1
0.2058	0.7572	1
0.3208	0.5502	1
0.0891	0.7486	1
0.004	0.2527	0.2986
0.0045	0.7476	1
0.0045	0.3198	1
0.0296	0.3335	1
0.0045	0.6992	1
0.1017	0.7766	1
0.0232	0.2699	0.2699
0.0039	0.7486	1
0.0045	0.7476	1
0.0972	0.6105	1
0.0985	0.358	1
0.0606	0.7043	1
0.1774	0.7572	1
0.0077	0.2803	1
0.0971	0.5959	1
0.0091	0.7396	1
0.0658	0.7712	1
0.0758	0.7468	1
0.0125	0.2661	1
0.0047	0.2667	0
0.0169	0.7486	1
0.0208	0.5823	1
0.0803	0.588	1
0.0635	0.7486	1
0.1416	0.7486	1
0.0045	0.7476	1
0.0112	0.3332	1
0.0045	0.7465	1
0.116	0.7486	1
0.034	0.7562	1
0.0928	0.7476	1
0.0128	0.262	1
0.0306	0.3517	1
0.1622	0.7486	1
0.0122	0.3398	1
0.1999	0.784	1
0.1017	0.4061	1
0.0968	0.7854	1
0.1186	0.3114	1
0.1368	0.4869	1
0.0038	0.4175	0.4175
0.0037	0.7417	1
0.0077	0.3203	1
0.1076	0.7562	1
0.1415	0.7428	1
0.0337	0.7465	1
0.0867	0.7486	1
0.0084	0.7476	1
0.0045	0.6992	1
0.0431	0.7437	1
0.0045	0.7476	1
0.1048	0.7799	1
0.1419	0.7476	1
0.0114	0.7465	1
0.0045	0.6992	1
0.0793	0.7486	1
0.0928	0.7476	1
0.1487	0.4678	1
0.1397	0.7572	1
0.0039	0.4175	0.4175
0.0117	0.7486	1
0.1174	0.747	1
0.0375	0.7486	1
0.1446	0.7562	1
0.0199	0.7486	1
0.0043	0.3107	1
0.0045	0.2593	0.3336
0.0073	0.7465	1
0.0522	0.3462	1
0.0998	0.6125	1
0.1735	0.7795	1
0.1563	0.7563	1
0.0408	0.7084	1
0.0045	0.6992	1
0.0149	0.7486	1
0.0045	0.7476	1
0.0046	0.3645	1
0.0264	0.3024	1
0.0045	0.7476	1
0.0045	0.2655	1
0.023	0.7562	1
0.0329	0.7476	1
0.0045	0.6938	1
0.0987	0.7853	1
0.0507	0.7486	1
0.0936	0.7851	1
0.0045	0.7461	1
0.0045	0.7476	1
0.0408	0.7084	1
0.0045	0.7465	1
0.0066	0.5858	1
0.148	0.7476	1
0.1569	0.7486	1
0.0438	0.7465	1
0.0946	0.691	1
0.0131	0.7417	1
0.0526	0.7476	1
0.098	0.3955	1
0.0257	0.642	1
0.0045	0.7476	1
0.0091	0.7407	1
0.0463	0.7486	1
0.008	0.3679	1
0.0224	0.7476	1
0.0936	0.7851	1
0.0835	0.7458	1
0.0991	0.7469	1
0.0077	0.4234	1
0.0902	0.7476	1
0.1363	0.7442	1
0.0327	0.7325	1
0.035	0.4303	1
0.0115	0.3243	0
0.005	0.7476	1
0.0946	0.691	1
0.013	0.6848	1
0.0037	0.5229	1
0.0693	0.338	1
0.0238	0.3582	1
0.0112	0.7476	1
0.0045	0.2655	1
0.011	0.5013	1
0.1858	0.7486	1
0.1871	0.7874	1
0.0492	0.7464	1
0.0045	0.3143	1
0.2067	0.7766	1
0.0038	0.4175	0.4175
0.0082	0.2743	1
0.0045	0.2613	1
0.0045	0.7476	1
0.023	0.4232	1
0.031	0.671	1
0.1313	0.7675	1
0.1161	0.7872	1
0.0936	0.7851	1
0.0045	0.2583	1
0.0197	0.3362	1
0.1116	0.7669	1
0.0111	0.7465	1
0.094	0.5643	1
0.0129	0.7562	1
0.0078	0.4071	1
0.0045	0.7476	1
0.0151	0.7152	1
0.142	0.7486	1
0.0151	0.7707	1
0.012	0.3058	1
0.0045	0.7476	1
0.0045	0.7476	1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier	ML0101 (Mycobacterium leprae), Polyketide synthase Pks13

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