Detailed view for TGME49_214400

Basic information

TDR Targets ID: 257814
Toxoplasma gondii, hypothetical protein
Source Database / ID:  ToxoDB 

pI: 10.2904 | Length (AA): 222 | MW (Da): 24861 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile ME49 Tachyzoite. Gregory
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile VEG Tachyzoite, ME49 Oocyst. Gregory Fritz HM
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile ME49 Bradyzoite. Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile ME49 merozoite. Hehl AB
Show/Hide expression data references
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_129299)

Species Accession Gene Product
Arabidopsis thaliana AT3G51840   acyl-coenzyme A oxidase 4
Caenorhabditis elegans CELE_F54D5.7   Protein F54D5.7
Dictyostelium discoideum DDB_G0283411   glutaryl-CoA dehydrogenase
Dictyostelium discoideum DDB_G0274585   hypothetical protein
Drosophila melanogaster Dmel_CG9547   CG9547 gene product from transcript CG9547-RA
Homo sapiens ENSG00000105607   glutaryl-CoA dehydrogenase
Mus musculus ENSMUSG00000003809   glutaryl-Coenzyme A dehydrogenase
Mycobacterium tuberculosis Rv0400c   Acyl-CoA dehydrogenase FadE7
Mycobacterium ulcerans MUL_2825   acyl-CoA dehydrogenase FadE7
Oryza sativa 4324062   Os01g0159400
Oryza sativa 4337904   Os05g0163700
Schmidtea mediterranea mk4.008512.01  
Schmidtea mediterranea mk4.008440.00  
Schmidtea mediterranea mk4.002644.03   Glutaryl-CoA dehydrogenase, mitochondrial
Schmidtea mediterranea mk4.022596.00  
Schmidtea mediterranea mk4.035706.00   Probable glutaryl-CoA dehydrogenase, mitochondrial
Trypanosoma cruzi TcCLB.510121.40   hypothetical protein
Trypanosoma cruzi TcCLB.508951.40   acyl-CoA dehydrogenase, putative
Toxoplasma gondii TGME49_214400   hypothetical protein
Toxoplasma gondii TGME49_231900   acyl-CoA dehydrogenase domain-containing protein

Essentiality

TGME49_214400 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu403 Mycobacterium tuberculosis essential nmpdr
TGME49_214400 this record Toxoplasma gondii Probably non-essential sidik
TGME49_231900 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TGME49_214400 (Toxoplasma gondii), hypothetical protein
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