Detailed view for LmjF.17.0870

Basic information

TDR Targets ID: 25937
Leishmania major, META domain containing protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.729 | Length (AA): 444 | MW (Da): 48460 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03724   META domain
PF09149   Domain of unknown function (DUF1935)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
337 438 1r75 (A) 12 118 39.00 0 1 0.76 -1.18
171 238 2n3z (A) 28 90 32.00 0.33 0.22 0.371053 0.48
220 334 2kts (A) 1 113 27.00 0 0.99 0.650909 -1.01
331 444 2fe0 (A) 6 118 41.00 0 1 0.788157 -0.47
340 444 1r75 (A) 15 124 37.00 0 1 0.744386 -1.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1R75:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2FE0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_142223)

Species Accession Gene Product
Leishmania braziliensis LbrM.17.1070   META domain containing protein, putative;with=GeneDB:LmjF17.0870
Leishmania donovani LdBPK_170970.1   hypothetical protein, conserved
Leishmania infantum LinJ.17.0970   META domain containing protein, putative;with=GeneDB:LmjF17.0870
Leishmania major LmjF.17.0870   META domain containing protein
Leishmania mexicana LmxM.17.0870   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.5.3180   hypothetical protein, conserved
Trypanosoma brucei Tb927.5.2190   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma brucei Tb927.5.2250   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma brucei Tb927.5.2220   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma congolense TcIL3000_0_28530   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma congolense TcIL3000_0_56910   META domain/Domain of unknown function (DUF1935), putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major small myristoylated protein-3, putative 115 aa 50.9% 106 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.026 0.3022 0.3022
0.0615 0.299 0.2979
0.0267 0.2923 0.2862
0.0651 0.299 0.2979
0.0278 0.281 0.2745
0.0264 0.2862 0.2862
0.0311 0.2891 0.2874
0.0205 0.2872 0.2745
0.0262 0.3022 0.3022
0.0274 0.269 0.295
0.0294 0.3051 0.3068
0.0292 0.302 0.302
0.0284 0.2935 0.2909
0.0294 0.3112 0.3096
0.0293 0.3007 0.2962
0.0269 0.3112 0.3096
0.0293 0.3022 0.3022
0.0500157 0.280356 0.27328
0.0288 0.3022 0.3022
0.0267 0.2923 0.2862
0.0323 0.3066 0.295
0.0265 0.2968 0.2909
0.021 0.316 0.3154
0.0287 0.2746 0.2962
0.0292 0.302 0.302
0.0292 0.2941 0.2958
0.0654 0.3006 0.295
0.0269 0.2915 0.2909
0.0317 0.3007 0.2962
0.0468 0.299 0.2979
0.0261 0.2734 0.295
0.0314 0.307 0.3068
0.0261 0.2734 0.295
0.0314 0.3007 0.2962
0.0323 0.2852 0.2784
0.0619 0.299 0.2979
0.0263 0.2909 0.2909
0.0208 0.301 0.301
0.0263 0.3103 0.3096
0.0259 0.3022 0.3022
0.0291 0.2951 0.295
0.0647 0.2979 0.295
0.0304 0.3065 0.3106
0.032 0.3023 0.3022
0.031 0.2997 0.2914
0.0264 0.3022 0.3022
0.0318 0.3117 0.3114
0.0271 0.3007 0.2962
0.0278 0.3096 0.3096
0.0353 0.2581 0.3099
0.0249 0.2651 0.2651
0.0301 0.2936 0.2909
0.0619 0.299 0.2979
0.0304 0.2959 0.3068
0.0299 0.3007 0.2962
0.0262 0.3027 0.3022
0.0311 0.2891 0.2874
0.0587 0.299 0.2979
0.0146 0.2979 0.295
0.0587 0.299 0.2979
0.0318 0.3117 0.3114
0.0276 0.2611 0.2813
0.0285 0.2943 0.295
0.0293 0.3007 0.2962
0.0278 0.3007 0.2962
0.0265 0.3103 0.3096
0.0262 0.2951 0.295
0.0203 0.2672 0.2651
0.0647 0.3006 0.295
0.0304 0.3008 0.3068
0.0259 0.2877 0.3114
0.0615 0.299 0.2979
0.0285 0.2635 0.2954
0.0323 0.3111 0.3107
0.0293 0.2979 0.295
0.0269 0.3022 0.3022
0.0265 0.3103 0.3096
0.0263 0.307 0.3068
0.0312 0.307 0.3068
0.0317 0.3007 0.2962
0.0271 0.3027 0.3022
0.0263 0.2832 0.2697
0.0262 0.2859 0.2745
0.0555 0.299 0.2979
0.0144 0.2852 0.2745
0.0279 0.2938 0.2909
0.0249 0.2651 0.2651
0.0274 0.269 0.295
0.0275 0.3112 0.3096
0.0284 0.2873 0.2827
0.0276 0.2792 0.3114
0.0293 0.2965 0.2909
0.0292 0.302 0.302
0.0263 0.307 0.3068
0.0292 0.2872 0.2849
0.0261 0.2734 0.295
0.0317 0.3007 0.2962
0.0285 0.2766 0.2989
0.0288 0.3022 0.3022
0.0651 0.299 0.2979
0.0276 0.2792 0.3114
0.031 0.3022 0.3022
0.0282 0.3112 0.3096
0.0323 0.2888 0.2888
0.0647 0.3006 0.295
0.0323 0.3111 0.3107
0.0273 0.3112 0.3096
0.032 0.307 0.3068
0.0647 0.299 0.2979
0.0275 0.3007 0.2962
0.0278 0.3022 0.3022
0.0587 0.299 0.2979
0.0555 0.299 0.2979
0.0249 0.2651 0.2651
0.0269 0.3022 0.3022
0.0275 0.3007 0.2962
0.0619 0.299 0.2979
0.03 0.3112 0.3097
0.0289 0.2888 0.2847
0.0299 0.3038 0.3038
0.0289 0.2668 0.2956
0.0304727 0.252447 0.250702
0.0314 0.307 0.3068
0.032 0.307 0.3068
0.0615 0.299 0.2979
0.0278 0.3022 0.3022
0.0651 0.299 0.2979
0.0583 0.299 0.2979
0.0283 0.3007 0.2962
0.0287 0.2746 0.2962
0.0289 0.2951 0.295
0.0269 0.3022 0.3022
0.0587219 0.280237 0.27328
0.0273 0.2915 0.2909
0.0262 0.3027 0.3022
0.0305 0.3022 0.3022
0.0281 0.2806 0.2821
0.0279 0.3103 0.3096
0.0323 0.3111 0.3107
0.0315 0.3112 0.3097
0.0317 0.3022 0.3022
0.0500157 0.280356 0.27328
0.0647 0.299 0.2979
0.0268 0.3022 0.3022
0.0583 0.299 0.2979
0.0266 0.2706 0.307
0.0276 0.3007 0.2962
0.0276 0.2792 0.3114
0.0208 0.301 0.301
0.0249 0.2651 0.2651
0.0268 0.2883 0.2816
0.0318 0.307 0.3068
0.0279 0.2915 0.2909
0.0312 0.307 0.3068
0.0323 0.2952 0.295
0.0144 0.2745 0.2745
0.0318 0.3117 0.3114
0.0267 0.2938 0.2909
0.0282 0.2706 0.3096
0.0269 0.3022 0.3022
0.0275 0.2934 0.2909
0.0615 0.299 0.2979
0.0304 0.3008 0.3068
0.026 0.3098 0.3068
0.0208 0.2991 0.295

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LmjF.17.0870 (Leishmania major), META domain containing protein
Title for this comment
Comment