pI: 9.1904 |
Length (AA): 664 |
MW (Da): 71159 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
61 | 482 | 3dk9 (A) | 30 | 458 | 23.00 | 0.087 | 0.96 | 0.548242 | 1.56 |
78 | 218 | 1nyk (A) | 56 | 197 | 21.00 | 0 | 0.23 | 0.400249 | -0.1 |
111 | 215 | 1fqt (A) | 4 | 105 | 27.00 | 0 | 1 | 0.604033 | -1.24 |
111 | 212 | 2qpz (A) | 5 | 102 | 35.00 | 0 | 1 | 0.644514 | -1.01 |
234 | 652 | 1q1r (A) | 5 | 416 | 27.00 | 0 | 1 | 0.968724 | -0.15 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Oocyst. | Fritz HM |
Gregory | ToxoDB |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_126784)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G27820 | monodehydroascorbate reductase (NADH) |
Arabidopsis thaliana | AT3G52880 | monodehydroascorbate reductase 1 |
Arabidopsis thaliana | AT3G09940 | monodehydroascorbate reductase (NADH) |
Arabidopsis thaliana | AT1G63940 | Monodehydroascorbate reductase |
Arabidopsis thaliana | AT5G03630 | monodehydroascorbate reductase (NADH) |
Babesia bovis | BBOV_III001680 | pyridine nucleotide-disulphide oxidoreductase domain containing protein |
Caenorhabditis elegans | CELE_F20D6.11 | Protein F20D6.11 |
Drosophila melanogaster | Dmel_CG10700 | CG10700 gene product from transcript CG10700-RA |
Drosophila melanogaster | Dmel_CG4199 | CG4199 gene product from transcript CG4199-RG |
Escherichia coli | b2711 | NADH:flavorubredoxin oxidoreductase |
Escherichia coli | b3365 | nitrite reductase, large subunit, NAD(P)H-binding |
Escherichia coli | b2542 | phenylpropionate dioxygenase, ferredoxin reductase subunit |
Entamoeba histolytica | EHI_153000 | pyridine nucleotide-disulfide oxidoreductase family protein |
Giardia lamblia | GL50803_33769 | NADH oxidase lateral transfer candidate |
Homo sapiens | ENSG00000183773 | apoptosis-inducing factor, mitochondrion-associated, 3 |
Mus musculus | ENSMUSG00000022763 | apoptosis-inducing factor, mitochondrion-associated 3 |
Mycobacterium tuberculosis | Rv0688 | Putative ferredoxin reductase |
Mycobacterium tuberculosis | Rv3303c | NAD(P)H quinone reductase LpdA |
Mycobacterium tuberculosis | Rv0252 | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB |
Mycobacterium tuberculosis | Rv1869c | Probable reductase |
Mycobacterium ulcerans | MUL_0769 | ferredoxin reductase |
Mycobacterium ulcerans | MUL_2668 | flavoprotein disulfide reductase |
Neospora caninum | NCLIV_029160 | Pyridine nucleotide-disulphide oxidoreductase family protein, related |
Neospora caninum | NCLIV_002590 | Phthalate dioxygenase reductase subunit, related |
Oryza sativa | 4346299 | Os08g0557600 |
Oryza sativa | 4330469 | Os02g0707100 |
Oryza sativa | 4330468 | Os02g0707000 |
Oryza sativa | 4344670 | Os08g0151800 |
Oryza sativa | 4347885 | Os09g0567300 |
Plasmodium berghei | PBANKA_0617900 | ferrodoxin reductase-like protein, putative |
Plasmodium falciparum | PF3D7_0720400 | ferrodoxin reductase-like protein |
Plasmodium knowlesi | PKNH_0315800 | ferrodoxin reductase-like protein |
Plasmodium vivax | PVX_096305 | ferrodoxin reductase, putative |
Plasmodium yoelii | PY01431 | Tamegoloh, putative |
Toxoplasma gondii | TGME49_207620 | pyridine nucleotide-disulfide oxidoreductase domain-containing protein |
Toxoplasma gondii | TGME49_255890 | pyridine nucleotide-disulfide oxidoreductase domain-containing protein |
Treponema pallidum | TP0921 | NADH oxidase |
Theileria parva | TP03_0672 | oxidoreductase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu255 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu700 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1899 | Mycobacterium tuberculosis | non-essential | nmpdr |
b2542 | Escherichia coli | non-essential | goodall |
b2711 | Escherichia coli | non-essential | goodall |
b3365 | Escherichia coli | non-essential | goodall |
TGME49_255890 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_207620 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_255890 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_207620 this record | Toxoplasma gondii | Probably non-essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.