Detailed view for LmjF.31.1610
Basic information
TDR Targets ID: 26275
Leishmania major, diphthine synthase-like protein
Source Database / ID: TriTrypDB GeneDB
Leishmania major, diphthine synthase-like protein
Source Database / ID: TriTrypDB GeneDB
pI: 5.1609 |
Length (AA): 271 |
MW (Da): 29459 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00590
Tetrapyrrole (Corrin/Porphyrin) Methylases
Gene Ontology
Mouse over links to read term descriptions.
GO:0008168
methyltransferase activity GO:0004164 diphthine synthase activity
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0008152 metabolic process
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 271 | 1vhv (A) | 1 | 244 | 37.00 | 0 | 1 | 1.3 | -0.86 |
| 1 | 271 | 1wde (A) | 9 | 269 | 24.00 | 0 | 1 | 1.24 | -0.93 |
| 5 | 270 | 2dek (A) | 6 | 255 | 41.00 | 0 | 1 | 1.48 | -0.8 |
| 1 | 269 | 1vhv (A) | 1 | 242 | 39.00 | 0 | 1 | 1.36772 | -0.48 |
| 1 | 270 | 3i4t (A) | 1 | 270 | 55.00 | 0 | 1 | 1.57991 | -0.19 |
| 2 | 108 | 3hh1 (A) | 11 | 118 | 15.00 | 0.041 | 0.47 | 0.683434 | -0.97 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
-
Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.
Orthologs
Ortholog group members (OG5_127443)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT4G31790 | Probable diphthine synthase |
| Babesia bovis | BBOV_IV002920 | diphthine synthase |
| Brugia malayi | Bm1_10785 | diphthine synthase |
| Candida albicans | CaO19.6676 | one of two genes similar to S. cerevisiae DPH5 (YLR172C) diphthamide methyltransferase (Tetrapyrrole Methylase domain) |
| Candida albicans | CaO19.6682 | similar to C terminus of S. cerevisiae DPH5 (YLR172C) diphthamide methyltransferase |
| Caenorhabditis elegans | CELE_B0491.7 | Protein B0491.7 |
| Cryptosporidium hominis | Chro.60154 | tetrapyrrole methylases |
| Cryptosporidium parvum | cgd6_1200 | diphthine synthase; diphthamide biosynthesis methyltransferase |
| Dictyostelium discoideum | DDB_G0276115 | diphthamide biosynthesis protein 5 |
| Drosophila melanogaster | Dmel_CG31289 | Diphthamide methyltransferase |
| Echinococcus granulosus | EgrG_000439900 | diphthine synthase |
| Entamoeba histolytica | EHI_127240 | diphthine synthase, putative |
| Echinococcus multilocularis | EmuJ_000439900 | diphthine synthase |
| Giardia lamblia | GL50803_28666 | Diphthine synthase |
| Homo sapiens | 51611 | diphthamide biosynthesis 5 |
| Leishmania braziliensis | LbrM.31.1820 | diphthine synthase-like protein |
| Leishmania donovani | LdBPK_311640.1 | diphthine synthase-like protein |
| Leishmania infantum | LinJ.31.1640 | diphthine synthase-like protein |
| Leishmania major | LmjF.31.1610 | diphthine synthase-like protein |
| Leishmania mexicana | LmxM.30.1610 | diphthine synthase-like protein |
| Loa Loa (eye worm) | LOAG_02159 | hypothetical protein |
| Mus musculus | ENSMUSG00000033554 | DPH5 homolog (S. cerevisiae) |
| Neospora caninum | NCLIV_066040 | diphthine synthase, putative |
| Oryza sativa | 4332866 | Os03g0355800 |
| Plasmodium berghei | PBANKA_1207300 | diphthine methyl ester synthase, putative |
| Plasmodium falciparum | PF3D7_1009000 | diphthine methyl ester synthase, putative |
| Plasmodium knowlesi | PKNH_0808700 | diphthine methyl ester synthase, putative |
| Plasmodium vivax | PVX_094665 | diphthine synthase, putative |
| Plasmodium yoelii | PY01561 | diphthine synthase |
| Saccharomyces cerevisiae | YLR172C | diphthine synthase |
| Schistosoma japonicum | Sjp_0305750 | ko:K00586 diphthine synthase [EC2.1.1.98], putative |
| Schistosoma japonicum | Sjp_0098940 | Diphthine synthase, putative |
| Schistosoma mansoni | Smp_025570.2 | diphthine synthase |
| Schmidtea mediterranea | mk4.001420.03 | Diphthine synthase |
| Trypanosoma brucei gambiense | Tbg972.4.4830 | diphthine synthase, putative |
| Trypanosoma brucei | Tb927.4.4650 | diphthine synthase, putative |
| Trypanosoma congolense | TcIL3000_4_4000 | diphthine synthase, putative |
| Trypanosoma cruzi | TcCLB.407477.30 | diphthine synthase, putative |
| Trypanosoma cruzi | TcCLB.511389.130 | diphthine synthase, putative |
| Toxoplasma gondii | TGME49_249920 | diphthine synthase, putative |
| Theileria parva | TP01_0634 | diphthine synthase, putative |
Essentiality
LmjF.31.1610 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.4.4650 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.4.4650 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.4.4650 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.4.4650 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| TGME49_249920 | Toxoplasma gondii | Probably essential | sidik |
-
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
Phenotypes and Validation (curated)
Annotated phenotypes:
| Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
|---|---|---|---|---|---|---|
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 337527 561727 585910 |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 4174-73-6. chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in cell assay; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 7179420 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 337527 561727 585910 |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 4174-73-6. chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in cell assay; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 7179420 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from enzyme assay (ECO:0000005) | Leishmania mexicana | 337527 561727 585910 | |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 4174-73-6. chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 7179420 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania amazonensis | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | L-Amino acid esters appear to be hydrolyzed by cysteine peptidase and lead to slow growth of Leishmania sp. in cell assay; . | References: | 1428504 2235078 2345655 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in cell assay; . | References: | 2270108 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from enzyme assay (ECO:0000005) | Leishmania amazonensis | 81384 576750 | |
| Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 8023752 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from enzyme assay (ECO:0000005) | Leishmania major | 81384 576750 | |
| Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 8023752 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | host (GO:0018995) | Leishmania donovani | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 81989-95-9. chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse) and cure of parasite burden; also provided protection against further infection (partial vaccine); General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 11238649 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania donovani | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 81989-95-9. chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse) and cure of parasite burden; also provided protection against further infection (partial vaccine); General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 11238649 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | host (GO:0018995) | Leishmania tropica | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 233277-99-1. chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions) and reduced lesion size; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 15172223 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania tropica | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 233277-99-1. chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions) and reduced lesion size; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 15172223 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania tropica | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 233277-99-1. chemical inhibition with known cysteine peptidase inhibitors leads to slow growth of Leishmania sp. in cell assay; inhibitors overcome redundancy?; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 15172223 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 0 6693 81384 236103 327961 376038 543486 543487 575389 575390 575391 576750 |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 22386-37-4; Drug: 36677-78-8; Drug: 52090-11-6; Drug: 98319-30-3; Drug: 300670-24-0; Drug: 302939-54-4; Drug: 303216-44-6; Drug: 309742-24-3; Drug: 312280-89-0; Drug: 315703-20-9; Drug: 320369-30-0; Drug: 322409-94-9; Drug: 330220-86-5; Drug: 335206-77-4; Drug: 347910-28-5; Drug: 352560-86-2; Drug: 363180-61-4; Drug: 413580-11-7; Drug: 416878-80-3; Drug: 419547-26-5; Drug: 428852-79-3; Drug: 825612-08-6; Drug: 825612-09-7; Drug: 825612-10-0. in silico virtual screening of falcipains lead to bioactive compounds against Leishmania promastigotes; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 15588096 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from in-silico analysis (ECO:0000043) | Leishmania donovani | 0 6693 81384 236103 327961 376038 543486 543487 575389 575390 575391 576750 | |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 22386-37-4; Drug: 36677-78-8; Drug: 52090-11-6; Drug: 98319-30-3; Drug: 300670-24-0; Drug: 302939-54-4; Drug: 303216-44-6; Drug: 309742-24-3; Drug: 312280-89-0; Drug: 315703-20-9; Drug: 320369-30-0; Drug: 322409-94-9; Drug: 330220-86-5; Drug: 335206-77-4; Drug: 347910-28-5; Drug: 352560-86-2; Drug: 363180-61-4; Drug: 413580-11-7; Drug: 416878-80-3; Drug: 419547-26-5; Drug: 428852-79-3; Drug: 825612-08-6; Drug: 825612-09-7; Drug: 825612-10-0. in silico virtual screening of falcipains lead to bioactive compounds against cysteine protease in vitro; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 15588096 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | 0 6693 81384 236103 327961 376038 543486 543487 575389 575390 575391 576750 | |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 22386-37-4; Drug: 36677-78-8; Drug: 52090-11-6; Drug: 98319-30-3; Drug: 300670-24-0; Drug: 302939-54-4; Drug: 303216-44-6; Drug: 309742-24-3; Drug: 312280-89-0; Drug: 315703-20-9; Drug: 320369-30-0; Drug: 322409-94-9; Drug: 330220-86-5; Drug: 335206-77-4; Drug: 347910-28-5; Drug: 352560-86-2; Drug: 363180-61-4; Drug: 413580-11-7; Drug: 416878-80-3; Drug: 419547-26-5; Drug: 428852-79-3; Drug: 825612-08-6; Drug: 825612-09-7; Drug: 825612-10-0. in silico virtual screening of falcipains lead to bioactive compounds against cysteine protease in vitro; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 15588096 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 2935-91-3; Drug: 24117-97-3; Drug: 98647-23-5; Drug: 198124-18-4; Drug: 256238-87-6; Drug: 257287-52-8; Drug: 263157-80-8; Drug: 294854-43-6; Drug: 303124-84-7; Drug: 303147-38-8; Drug: 321579-84-4; Drug: 331247-87-1; Drug: 337923-53-2; Drug: 338791-39-2; Drug: 675828-74-7; Drug: 676226-56-5; Drug: 678967-57-2; Drug: 681213-40-1; Drug: 686272-33-3; Drug: 696586-43-3; Drug: 705250-31-3; Drug: 708987-83-1; Drug: 831234-40-3; Drug: 882161-95-7; Drug: 882161-98-0; Drug: 882161-99-1; Drug: 882162-00-7; Drug: 882162-01-8; Drug: 882162-02-9; Drug: 882162-03-0; Drug: 882162-04-1; Drug: 882162-05-2; Drug: 882162-06-3; Drug: 882162-07-4; Drug: 882162-08-5; Drug: 882162-09-6; Drug: 882162-10-9; Drug: 882162-11-0; Drug: 882162-12-1; Drug: 882162-13-2; Drug: 882162-14-3. in silico virtual screening of falcipains lead to bioactive compounds against Leishmania promastigotes; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 16509575 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from in-silico analysis (ECO:0000043) | Leishmania donovani | No drug identifiers listed for this gene. | |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 2935-91-3; Drug: 24117-97-3; Drug: 98647-23-5; Drug: 198124-18-4; Drug: 256238-87-6; Drug: 257287-52-8; Drug: 263157-80-8; Drug: 294854-43-6; Drug: 303124-84-7; Drug: 303147-38-8; Drug: 321579-84-4; Drug: 331247-87-1; Drug: 337923-53-2; Drug: 338791-39-2; Drug: 675828-74-7; Drug: 676226-56-5; Drug: 678967-57-2; Drug: 681213-40-1; Drug: 686272-33-3; Drug: 696586-43-3; Drug: 705250-31-3; Drug: 708987-83-1; Drug: 831234-40-3; Drug: 882161-95-7; Drug: 882161-98-0; Drug: 882161-99-1; Drug: 882162-00-7; Drug: 882162-01-8; Drug: 882162-02-9; Drug: 882162-03-0; Drug: 882162-04-1; Drug: 882162-05-2; Drug: 882162-06-3; Drug: 882162-07-4; Drug: 882162-08-5; Drug: 882162-09-6; Drug: 882162-10-9; Drug: 882162-11-0; Drug: 882162-12-1; Drug: 882162-13-2; Drug: 882162-14-3. in silico virtual screening of falcipains lead to bioactive compounds against cysteine protease in vitro; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 16509575 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | No drug identifiers listed for this gene. | |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 2935-91-3; Drug: 24117-97-3; Drug: 98647-23-5; Drug: 198124-18-4; Drug: 256238-87-6; Drug: 257287-52-8; Drug: 263157-80-8; Drug: 294854-43-6; Drug: 303124-84-7; Drug: 303147-38-8; Drug: 321579-84-4; Drug: 331247-87-1; Drug: 337923-53-2; Drug: 338791-39-2; Drug: 675828-74-7; Drug: 676226-56-5; Drug: 678967-57-2; Drug: 681213-40-1; Drug: 686272-33-3; Drug: 696586-43-3; Drug: 705250-31-3; Drug: 708987-83-1; Drug: 831234-40-3; Drug: 882161-95-7; Drug: 882161-98-0; Drug: 882161-99-1; Drug: 882162-00-7; Drug: 882162-01-8; Drug: 882162-02-9; Drug: 882162-03-0; Drug: 882162-04-1; Drug: 882162-05-2; Drug: 882162-06-3; Drug: 882162-07-4; Drug: 882162-08-5; Drug: 882162-09-6; Drug: 882162-10-9; Drug: 882162-11-0; Drug: 882162-12-1; Drug: 882162-13-2; Drug: 882162-14-3. in silico virtual screening of falcipains lead to bioactive compounds against cysteine protease in vitro; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 16509575 | |
| growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania major | No drug identifiers listed for this gene. |
| Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 872361-01-8; Drug: 872361-02-9; Drug: 886061-72-9; Drug: 886061-73-0; Drug: 886061-74-1; Drug: 886061-75-2; Drug: 886061-76-3; Drug: 886061-77-4; Drug: 886061-78-5; Drug: 886061-79-6; Drug: 886061-80-9; Drug: 886061-81-0; Drug: 886061-82-1; Drug: 886061-85-4; Drug: 886061-86-5; Drug: 886061-87-6; Drug: 886061-88-7; Drug: 886061-89-8; Drug: 886061-90-1; Drug: 886061-91-2; Drug: 886061-92-3; Drug: 886061-93-4; Drug: 886061-99-0; Drug: 886062-00-6; Drug: 886062-05-1; Drug: 886062-06-2; Drug: 886062-07-3; Drug: 886062-08-4; Drug: 886062-09-5; Drug: 886062-10-8; Drug: 886062-11-9; Drug: 886062-12-0; Drug: 886062-13-1; Drug: 886062-14-2; Drug: 886062-15-3; Drug: 886062-16-4; Drug: 886062-17-5; Drug: 906674-95-1. chemical inhibition with peptidomimetics and Aziridine-2,3-dicarboxylates leads to slow growth of Leishmania sp. in cell assay; General cysteine peptidase inhibition with anti-leishmanial activity; specific target unknown. | References: | 16801424 | |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
- Validation: inhibited in cell-free system
- annotated by: aaronjr@u.washington.edu.
- References: 15588096 16509575 7179420 8023752
Associated compounds / Druggability
Druggability index (range: 0 to 1): 0.2
Known modulators for this target
| Compound | Source | Reference |
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| Curated by TDRTargets | References | |
| Curated by TDRTargets | References | |
| Curated by TDRTargets | References | |
| Curated by TDRTargets | References |
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
11 literature references were collected for this gene.
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User comments
No user comments are available for this gene.
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