pI: 5.3641 |
Length (AA): 643 |
MW (Da): 69156 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
28 | 124 | 2mqa (A) | 33 | 123 | 16.00 | 0 | 0.06 | 0.248055 | -0.14 |
221 | 601 | 3psg (A) | 2 | 324 | 31.00 | 0 | 1 | 0.969835 | -0.58 |
267 | 609 | 1wkr (A) | 1 | 339 | 23.00 | 0 | 1 | 0.735637 | -0.29 |
269 | 608 | 1mpp (A) | 3 | 331 | 23.00 | 0 | 1 | 0.773971 | -0.42 |
269 | 510 | 1b5f (A) | 2 | 235 | 35.00 | 0 | 1 | 0.731561 | -0.01 |
270 | 602 | 1qdm (A) | 7 | 337 | 33.00 | 0 | 1 | 0.720085 | -0.99 |
272 | 361 | 4od9 (A) | 6 | 95 | 37.00 | 0 | 0.7 | 0.522169 | -0.04 |
520 | 602 | 1b5f (B) | 249 | 325 | 41.00 | 0.000034 | 1 | 0.483382 | 0.25 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_133546)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV007890 | aspartyl protease, putative |
Cryptosporidium parvum | cgd6_660 | secreted pepsinogen like aspartyl protease having a signal peptide |
Homo sapiens | 643834 | pepsinogen 3, group I (pepsinogen A) |
Homo sapiens | 101929842 | pepsin A-3-like |
Homo sapiens | 643847 | pepsinogen 4, group I (pepsinogen A) |
Homo sapiens | ENSG00000256713 | pepsinogen 5, group I (pepsinogen A) |
Mus musculus | ENSMUSG00000046213 | chymosin |
Neospora caninum | NCLIV_063340 | hypothetical protein |
Plasmodium berghei | PBANKA_1222500 | plasmepsin X |
Plasmodium berghei | PBANKA_1014500 | plasmepsin IX, putative |
Plasmodium falciparum | PF3D7_0808200 | plasmepsin X |
Plasmodium falciparum | PF3D7_1430200 | plasmepsin IX |
Plasmodium knowlesi | PKNH_0110500 | eukaryotic aspartyl protease, putative |
Plasmodium knowlesi | PKNH_1328500 | aspartyl protease, putative |
Plasmodium vivax | PVX_088125 | aspartyl protease, putative |
Plasmodium vivax | PVX_085030 | aspartyl protease, putative |
Plasmodium yoelii | PY01268 | pepsinogen A-related |
Plasmodium yoelii | PY06692 | Eukaryotic aspartyl protease, putative |
Toxoplasma gondii | TGME49_246550 | aspartyl protease ASP3 |
Theileria parva | TP03_0307 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1014500 | Plasmodium berghei | Essential | plasmo |
PBANKA_1222500 | Plasmodium berghei | Essential | plasmo |
TGME49_246550 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Sus scrofa | Pepsin A | Compounds | References |
Homo sapiens | pepsinogen 5, group I (pepsinogen A) | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bos taurus | Cathepsin D | 390 aa | 32.2% | 345 aa | Compounds | References |
Rhizopus microsporus var. chinensis | Rhizopuspepsin | 393 aa | 24.7% | 336 aa | Compounds | References |
Macaca fascicularis | Renin | 406 aa | 32.2% | 354 aa | Compounds | References |
Macaca mulatta | Renin | 406 aa | 32.2% | 354 aa | Compounds | References |
Rattus norvegicus | Renin | 402 aa | 29.9% | 324 aa | Compounds | References |
Schistosoma mansoni | cathepsin D (A01 family) | 428 aa | 32.5% | 345 aa | Compounds | References |
Oryctolagus cuniculus | Renin | 280 aa | 27.9% | 290 aa | Compounds | References |
Rattus norvegicus | Pepsinogen C | 392 aa | 36.7% | 335 aa | Compounds | References |
Schistosoma mansoni | cathepsin D (A01 family) | 430 aa | 32.5% | 345 aa | Compounds | References |
Callithrix jacchus | Renin | 400 aa | 32.8% | 335 aa | Compounds | References |
13 literature references were collected for this gene.