Detailed view for PVX_081540

Basic information

TDR Targets ID: 269250
Plasmodium vivax, ubiquitin carboxyl-terminal hydrolase 1, putative
Source Database / ID:  PlasmoDB 

pI: 7.8882 | Length (AA): 3699 | MW (Da): 412491 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  
GO:0004221   ubiquitin thiolesterase activity  
GO:0006511   ubiquitin-dependent protein catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
296 735 2f1z (A) 142 525 21.00 0 1 0.51 0.98
363 727 2gfo (A) 774 1106 23.00 0 1 0.6 -0.03
31 252 5cwm (A) 6 227 11.00 0.93 0.01 0.186116 -0.69
465 549 2zux (A) 204 292 36.00 0.99 0.24 0.192579 0.37
501 624 3gq8 (A) 560 682 30.00 0.81 0.03 0.322123 -0.33
1498 1718 5cwi (A) 4 231 13.00 0.63 0.02 0.128746 -0.07
1705 1842 3k29 (A) 18 152 10.00 0.28 0.01 0.160407 -0.66
2968 3000 2em9 (A) 5 44 15.00 0.0061 0 0.0409213 -1.12
3325 3697 2f1z (B) 214 528 29.00 0.00000069 1 0.00243806 1.01
3326 3686 3n3k (A) 778 1106 29.00 0.0000000000056 1 0.260194 0.2
3616 3688 3ihp (A) 778 832 38.00 0.62 0.27 0.0698351 0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_146935)

Species Accession Gene Product
Plasmodium berghei PBANKA_0208800   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium falciparum PF3D7_0104300   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium knowlesi PKNH_0209200   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium vivax PVX_081540   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium yoelii PY06943   hypothetical protein
Plasmodium yoelii PY01242   Ubiquitin carboxyl-terminal hydrolase family 2, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_081540 (Plasmodium vivax), ubiquitin carboxyl-terminal hydrolase 1, putative
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