TDR Targets

Detailed view for PVX_098070

Basic information

TDR Targets ID: 269532
Plasmodium vivax, cyclophilin, putative
Source Database / ID: PlasmoDB / PVX_098070

pI: 6.2462 | Length (AA): 737 | MW (Da): 83244 | Number of Paralogs: 0

EC number(s): 5.2.1.8 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: 0

[DGPI v2.04]

N-term Signal :

  there ISN'T a N-term signal

  maximal score=0.46



C-term Hydrophobicity profile :

  hydrophobe length (low-pass filter)=7

  hydrophile length (low-pass filter)=20

  hydrophobe length (median filter)=7

  hydrophile length (median filter)=30

  average hydrophobe length = 7.0

  average hydrophile length = 25.0



Cleavage site (w) :

  no cleavage site detected (w, w+2 rule not respected).



Conclusion :

  This protein is not GPI-anchored (no signal).

  No cleavage site detected.

Pfam domains

PF00400 WD40

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003755 peptidyl-prolyl cis-trans isomerase activity

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: PVX_098070

PDB structures: 2FU0

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 23
Cumulative epitope score: 26.0
Normalized epitope score: 3.5
Percentile: 20.8 (this protein belongs to the top 79.2% proteins in the genome of Plasmodium vivax, based on the predicted antigenicity).

[+/–] More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_11783
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_190046 CYP71 (CYCLOPHILIN71); chromatin binding / histone binding ... | OrthoMCL
Babesia bovis XP_001610877.1 peptidyl-prolyl cis-trans isomerase ... | OrthoMCL
Brugia malayi Bm1_28740 cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmc... | OrthoMCL
Caenorhabditis elegans Y87G2A.6 CE24686 WBGene00000891 locus:cyn-15 cyclophilin status:Parti... | OrthoMCL
Cryptosporidium hominis Chro.70067 protein-related ... | OrthoMCL
Cryptosporidium muris CMU_006350 peptidyl-prolyl cis-trans isomerase, cyclophilin-type famil... | OrthoMCL
Cryptosporidium neoformas XP_568847 peptidyl-prolyl cis-trans isomerase ... | OrthoMCL
Cryptosporidium parvum cgd7_520 cyclincyclophilin like peptidyl-prolyl cis-trans isomerase ... | OrthoMCL
Drosophila melanogaster FBpp0072216 | OrthoMCL
Escherichia coli K12 NP_415058.1 peptidyl-prolyl cis-trans isomerase B (rotamase B) [Escheric... | OrthoMCL
Homo sapiens ENSP00000261308 | OrthoMCL
Mycobacterium leprae strain TN ML0011 Probable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A)... | OrthoMCL
Mus musculus ENSMUSP00000022226 | OrthoMCL
Mycobacterium tuberculosis Rv0009 PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE ... | OrthoMCL
Neospora caninum NCLIV_009630 | OrthoMCL
Oryza sativa NP_001062485 Os08g0557500 ... | OrthoMCL
Plasmodium berghei PB000833.02.0 cyclophilin, putative ... | OrthoMCL
Plasmodium chabaudi PCAS_110950 cyclophilin, putative ... | OrthoMCL
P. falciparum 3D7 PFE0505w cyclophilin, putative... | OrthoMCL
Plasmodium knowlesi PKH_102270 cyclophilin, putative ... | OrthoMCL
Plasmodium vivax PVX_098070 (this record). cyclophilin, putative... | OrthoMCL
Plasmodium yoelii PY03899 putative protein-related ... | OrthoMCL
Schistosoma mansoni Smp_133820 peptidyl-prolyl cis-trans isomerase-like... | OrthoMCL
Toxoplasma gondii TGME49_120640 cyclophilin, putative... | OrthoMCL

Essentiality PVX_098070 has essentiality data
Gene/Ortholog: mtu9 (OG4_11783); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco514 (OG4_11783); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco514 (OG4_11783); Phenotype: essential; Source study: gerdes
Gene/Ortholog: eco514 (OG4_11783); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco514 (OG4_11783); Phenotype: non-essential; Source study: shigen

[+/–] Show essentiality data references.

shigen: Profiling of E. coli Chromosome (PEC). National Institute of Genetics, Japan
http://www.shigen.nig.ac.jp/ecoli/pec/
keio: Systematic single-gene knock-out mutants of E. coli K12. The Keio Collection
http://ecoli.naist.jp/
gerdes: Experimental determination and system-level analysis of essential genes in E. coli MG1655. Gerdes et al., J Bacteriol. 2003 185:5673-84
http://www.integratedgenomics.com/online_material/gerdes/
blattner: Systematic mutagenesis of the E. coli (MG1655) genome. J Bacteriol 2004, 186:4921-4930
http://theseed.uchicago.edu/FIG/eggs.cgi
yeastgenome: Systematic deletion of yeast genes. Saccharomyces Genome Database
http://yeastgenome.org
nmpdr: Genome-scale essentiality datasets from published studies (M. tuberculosis). National Microbial Pathogen Data Resource
http://www.nmpdr.org/
neb: C. elegans RNAi phenotypes. Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
wormbase: C. elegans RNAi experiments. WormBase web site, http://www.wormbase.org, release WS170
http://www.wormbase.org

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Curated from literature

No chemical compounds is associated to this gene

Predicted associations

By orthology to known druggable targets
By sequence similarity to non orthologous druggable targets

Assayability

Assay information

Assay: Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ); Source: Sigma-Aldrich
Description: Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic references

No literature references are available for this gene.

If you have references for this gene, please enter them in a user comment (below) or contact us.

User comments

No user comments are available for this gene.

The TDR Targets Database v4

Detailed view for PVX_098070

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