Detailed view for LmjF.04.0320

Basic information

TDR Targets ID: 27001
Leishmania major, beta-fructofuranosidase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4407 | Length (AA): 486 | MW (Da): 54195 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00251   Glycosyl hydrolases family 32 N-terminal domain
PF08244   Glycosyl hydrolases family 32 C terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 322 1w2t (A) 120 390 21.00 0 0.93 0.69 0.59
5 461 3pij (A) 156 516 20.00 0 0.99 0.781129 0.96
84 293 1st8 (A) 195 427 28.00 0.000000000006 0.78 0.545099 1.18
314 366 2ll3 (A) 25 77 21.00 0 0.32 0.362853 -0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_134818)

Species Accession Gene Product
Arabidopsis thaliana AT3G13790   beta-fructofuranosidase, insoluble isoenzyme CWINV1
Arabidopsis thaliana AT3G13784   beta-fructofuranosidase, insoluble isoenzyme CWINV5
Arabidopsis thaliana AT2G36190   beta-fructofuranosidase, insoluble isoenzyme CWINV4
Arabidopsis thaliana AT3G52600   beta-fructofuranosidase, insoluble isoenzyme CWINV2
Arabidopsis thaliana AT1G55120   beta-fructofuranosidase 5
Leishmania braziliensis LbrM.04.0350   beta-fructofuranosidase, putative
Leishmania braziliensis LbrM.34.0640   beta-fructofuranosidase-like protein
Leishmania donovani LdBPK_350640.1   beta-fructofuranosidase-like protein
Leishmania donovani LdBPK_040300.1   beta-fructofuranosidase, putative
Leishmania infantum LinJ.35.0650   beta-fructofuranosidase-like protein
Leishmania infantum LinJ.04.0300   beta-fructofuranosidase, putative
Leishmania infantum LinJ.04.0310   beta-fructofuranosidase, putative
Leishmania major LmjF.04.0320   beta-fructofuranosidase, putative
Leishmania major LmjF.04.0310   beta-fructofuranosidase, putative
Leishmania major LmjF.35.0640   beta-fructofuranosidase-like protein
Leishmania mexicana LmxM.34.0640   beta-fructofuranosidase-like protein
Leishmania mexicana LmxM.04.0320  
Leishmania mexicana LmxM.04.0310   beta-fructofuranosidase, putative
Oryza sativa 4324001   Os01g0966700
Oryza sativa 4335789   Os04g0413200
Oryza sativa 4329561   Os02g0534400
Oryza sativa 4335790   Os04g0413500

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Invertase temp 55 (3.2.1.26 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.04.0320 (Leishmania major), beta-fructofuranosidase, putative
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