Detailed view for PF3D7_1441600

Basic information

TDR Targets ID: 2726
Plasmodium falciparum, acid cluster protein 33 homologue, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.881 | Length (AA): 569 | MW (Da): 67622 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00561   alpha/beta hydrolase fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0005575   cellular_component  
GO:0003674   molecular_function  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 280 1zd3 (A) 219 543 16.00 0 1 0.64 -0.92
25 280 1iup (A) 9 272 18.00 0 1 0.81 -1.7
32 284 1zd3 (A) 247 547 17.00 0 1 0.36 -0.97
32 283 1m33 (A) 3 258 13.00 0 0.93 0.52 -1.53
18 313 2y6u (A) 19 377 14.00 0.00000000071 1 0.534911 0.11
45 135 4gw3 (A) 6 105 20.00 0.0031 0.94 0.39063 -0.71
308 381 2af7 (A) 20 93 4.00 0.84 0 0.239753 -1.14
377 490 3e15 (A) 76 211 35.00 0.35 0.27 0.210751 -0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst, Male Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_131432)

Species Accession Gene Product
Arabidopsis thaliana AT4G12230   alpha/beta-Hydrolases superfamily protein
Babesia bovis BBOV_III003140   conserved hypothetical protein
Cryptosporidium hominis Chro.40470   hypothetical protein
Cryptosporidium parvum cgd4_4130   hypothetical protein
Dictyostelium discoideum DDB_G0289031   alpha/beta hydrolase fold-1 domain-containing protein
Echinococcus granulosus EgrG_000725100   maspardin
Echinococcus multilocularis EmuJ_000725100   maspardin
Homo sapiens ENSG00000090487   spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Mus musculus ENSMUSG00000032388   spastic paraplegia 21 homolog (human)
Neospora caninum NCLIV_056170   hypothetical protein, conserved
Oryza sativa 4348183   Os10g0169800
Plasmodium berghei PBANKA_1305500   acid cluster protein 33 homologue, putative
Plasmodium falciparum PF3D7_1441600   acid cluster protein 33 homologue, putative
Plasmodium knowlesi PKNH_1240700   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_118410   hypothetical protein, conserved
Plasmodium yoelii PY01295   hypothetical protein
Schmidtea mediterranea mk4.000644.04   Maspardin
Schmidtea mediterranea mk4.000644.03  
Toxoplasma gondii TGME49_312660   hypothetical protein
Theileria parva TP04_0138   hypothetical protein, conserved
Trichomonas vaginalis TVAG_363230   conserved hypothetical protein
Trichomonas vaginalis TVAG_107060   Maspardin, putative
Trichomonas vaginalis TVAG_035010   Maspardin, putative
Trichomonas vaginalis TVAG_353350   conserved hypothetical protein

Essentiality

PF3D7_1441600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_312660 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1441600 (Plasmodium falciparum), acid cluster protein 33 homologue, putative
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