Detailed view for Smp_105680.1

Basic information

TDR Targets ID: 282771
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.8509 | Length (AA): 578 | MW (Da): 66263 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04597   Ribophorin I

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005783   endoplasmic reticulum  
GO:0004579   dolichyl-diphosphooligosaccharide-protein glycotransferase activity  
GO:0006486   protein amino acid glycosylation  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
225 315 5dz9 (A) 697 777 31.00 0.81 0.04 0.133339 2.11
429 558 4ooj (A) 16 131 29.00 0.032 0.16 0.203813 0.7
436 576 6gy7 (C) 119 265 21.00 0 0.54 0.419545 -0.19
436 542 3fb2 (B) 1349 1464 16.00 0 0.24 0.349721 -1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129041)

Species Accession Gene Product
Arabidopsis thaliana AT2G01720   ribophorin I
Arabidopsis thaliana AT1G76400   ribophorin I
Brugia malayi Bm1_31230   Ribophorin I family protein
Candida albicans CaO19.6988   64-kDa subunit of oligosaccharyltransferase
Caenorhabditis elegans CELE_T22D1.4   Protein RIBO-1
Cryptosporidium hominis Chro.60585   ribophorin i
Cryptosporidium parvum cgd6_5070   ribophorin I -like, putative dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67kDa subunit precursor, signal pept
Dictyostelium discoideum DDB_G0293224   dolichyl-diphosphooligosaccharide-protein glycotransferase
Drosophila melanogaster Dmel_CG33303   CG33303 gene product from transcript CG33303-RB
Echinococcus granulosus EgrG_000996800   dolichyl diphosphooligosaccharide protein
Entamoeba histolytica EHI_029540   dolychil-diphosphooligosaccharide-- protein glycosyltransferase subunit, putative
Entamoeba histolytica EHI_093790   dolychil-diphosphooligosaccharide-- protein glycosyltransferase subunit, putative
Entamoeba histolytica EHI_045470   dolychil-diphosphooligosaccharide-- protein glycosyltransferase subunit, putative
Echinococcus multilocularis EmuJ_000996800   dolichyl diphosphooligosaccharide protein
Homo sapiens ENSG00000163902   ribophorin I
Loa Loa (eye worm) LOAG_00769   ribophorin I family protein
Mus musculus ENSMUSG00000030062   ribophorin I
Neospora caninum NCLIV_022370   Ribophorin I, related
Oryza sativa 4338348   Os05g0301500
Saccharomyces cerevisiae YJL002C   Ost1p
Schistosoma japonicum Sjp_0210050   ko:K00730 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC2.4.1.119], putative
Schistosoma mansoni Smp_105680.1   hypothetical protein
Schistosoma mansoni Smp_105680.2   hypothetical protein
Schmidtea mediterranea mk4.000243.03   Dolichyl-diphosphooligosaccharideALQ-protein glycosyltransferase subunit 1
Toxoplasma gondii TGME49_202568   hypothetical protein
Trichomonas vaginalis TVAG_322520   Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit precursor, putative

Essentiality

Smp_105680.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T22D1.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_T22D1.4 Caenorhabditis elegans larval arrest wormbase
CELE_T22D1.4 Caenorhabditis elegans slow growth wormbase
CELE_T22D1.4 Caenorhabditis elegans sterile wormbase
YJL002C Saccharomyces cerevisiae inviable yeastgenome
TGME49_202568 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_105680.1 (Schistosoma mansoni), hypothetical protein
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