Detailed view for Smp_002160

Basic information

TDR Targets ID: 282782
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 9.6018 | Length (AA): 678 | MW (Da): 74579 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05499   DNA methyltransferase 1-associated protein 1 (DMAP1)
PF16282   SANT/Myb-like domain of DAMP1

Gene Ontology

Mouse over links to read term descriptions.
GO:0045892   negative regulation of transcription, DNA-dependent  
GO:0043968   GO:histone H2A acetylation  

GO:0043967   GO:histone H4 acetylation  

GO:0035267   NuA4 histone acetyltransferase complex  
GO:0005634   nucleus  
GO:0006338   chromatin remodeling  
GO:0006281   DNA repair  
GO:0016481   negative regulation of transcription  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
133 207 4iej (A) 133 206 50.00 0 1 0.924519 -2.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128988)

Species Accession Gene Product
Arabidopsis thaliana AT2G47210   myb-like transcription factor family protein
Babesia bovis BBOV_IV011350   hypothetical protein
Brugia malayi Bm1_47540   DNA methyltransferase 1 associated protein 1
Candida albicans CaO19.7492   similar to S. cerevisiae YGR002C
Caenorhabditis elegans CELE_Y105E8A.17   Protein EKL-4, isoform B
Cryptosporidium hominis Chro.50273   hypothetical protein
Cryptosporidium parvum cgd5_1120   DNMAP1 like Myb domain
Dictyostelium discoideum DDB_G0288747   myb domain-containing protein
Drosophila melanogaster Dmel_CG11132   CG11132 gene product from transcript CG11132-RA
Echinococcus granulosus EgrG_001156500   dna methyltransferase 1 associated protein 1
Echinococcus granulosus EgrG_001156600   dna methyltransferase 1 associated protein
Echinococcus multilocularis EmuJ_001156500   dna methyltransferase 1 associated protein 1
Echinococcus multilocularis EmuJ_001156600   dna methyltransferase 1 associated protein
Homo sapiens ENSG00000178028   DNA methyltransferase 1 associated protein 1
Loa Loa (eye worm) LOAG_08762   DNA methyltransferase 1 associated protein 1
Mus musculus ENSMUSG00000009640   DNA methyltransferase 1-associated protein 1
Neospora caninum NCLIV_013650   hypothetical protein
Oryza sativa 4339468   Os05g0540800
Plasmodium berghei PBANKA_1127300   DNA methyltransferase 1-associated protein 1, putative
Plasmodium falciparum PF3D7_0628600   DNA methyltransferase 1-associated protein 1, putative
Plasmodium knowlesi PKNH_1121200   DNA methyltransferase 1-associated protein 1, putative
Plasmodium vivax PVX_114530   hypothetical protein, conserved
Plasmodium yoelii PY06369   hypothetical protein
Saccharomyces cerevisiae YGR002C   Swc4p
Schistosoma japonicum Sjp_0309920   DNA methyltransferase 1-associated protein 1, putative
Schistosoma japonicum Sjp_0100970   DNA methyltransferase 1-associated protein 1, putative
Schistosoma mansoni Smp_002160   hypothetical protein
Schmidtea mediterranea mk4.001143.01   DNA methyltransferase 1-associated protein 1
Toxoplasma gondii TGME49_213890   Myb family DNA-binding domain-containing protein
Theileria parva TP01_1173   hypothetical protein

Essentiality

Smp_002160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y105E8A.17 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y105E8A.17 Caenorhabditis elegans slow growth wormbase
CELE_Y105E8A.17 Caenorhabditis elegans sterile wormbase
YGR002C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1127300 Plasmodium berghei Slow plasmo
TGME49_213890 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_002160 (Schistosoma mansoni), hypothetical protein
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