Detailed view for Smp_018150

Basic information

TDR Targets ID: 282817
Schistosoma mansoni, mannosyl-oligosaccharide alpha-12-mannosidase
Source Database / ID:  GeneDB

pI: 6.6642 | Length (AA): 581 | MW (Da): 65912 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01532   Glycosyl hydrolase family 47

Gene Ontology

Mouse over links to read term descriptions.
GO:0004571   mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  
GO:0016020   membrane  
GO:0005509   calcium ion binding  
GO:0003824   catalytic activity  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
43 169 1sox (A) 84 235 30.00 0.52 0.36 0.264089 0.99
110 572 1nxc (A) 179 642 50.00 0 1 1.5701 -1.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126925)

Species Accession Gene Product
Arabidopsis thaliana AT3G21160   mannosyl-oligosaccharide 1,2-alpha-mannosidase
Arabidopsis thaliana AT1G51590   mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1
Arabidopsis thaliana AT1G30000   mannosyl-oligosaccharide 1,2-alpha-mannosidase
Brugia malayi Bm1_35990   Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1
Candida albicans CaO19.8638   alpha mannosidase
Candida albicans CaO19.1036   alpha mannosidase
Caenorhabditis elegans CELE_C52E4.5   Protein MANS-2, isoform B
Caenorhabditis elegans CELE_ZC410.3   Protein MANS-4, isoform B
Caenorhabditis elegans CELE_T03G11.4   Protein MANS-3
Caenorhabditis elegans CELE_D2030.1   Protein MANS-1
Dictyostelium discoideum DDB_G0284395   glycoside hydrolase family 47 protein
Dictyostelium discoideum DDB_G0268754   glycoside hydrolase family 47 protein
Dictyostelium discoideum DDB_G0292918   glycoside hydrolase family 47 protein
Dictyostelium discoideum DDB_G0284391   glycoside hydrolase family 47 protein
Dictyostelium discoideum DDB_G0284393   glycoside hydrolase family 47 protein
Drosophila melanogaster Dmel_CG11874   alpha Mannosidase Ib
Drosophila melanogaster Dmel_CG42275   alpha Mannosidase I
Echinococcus granulosus EgrG_000773200   endoplasmic reticulum mannosyl oligosaccharide
Echinococcus granulosus EgrG_000605100   mannosyl oligosaccharide 12 alpha mannosidase
Echinococcus multilocularis EmuJ_000605100   mannosyl oligosaccharide 1,2 alpha mannosidase
Echinococcus multilocularis EmuJ_000773200   endoplasmic reticulum mannosyl oligosaccharide
Echinococcus multilocularis EmuJ_000024800   transfer RNA-Trp
Homo sapiens ENSG00000177239   mannosidase, alpha, class 1B, member 1
Homo sapiens ENSG00000111885   mannosidase, alpha, class 1A, member 1
Homo sapiens ENSG00000117643   mannosidase, alpha, class 1C, member 1
Homo sapiens ENSG00000198162   mannosidase, alpha, class 1A, member 2
Homo sapiens 101930307   uncharacterized LOC101930307
Loa Loa (eye worm) LOAG_01198   hypothetical protein
Loa Loa (eye worm) LOAG_12647   mannosidase
Loa Loa (eye worm) LOAG_03653   hypothetical protein
Loa Loa (eye worm) LOAG_03652   hypothetical protein
Mus musculus ENSMUSG00000037306   mannosidase, alpha, class 1C, member 1
Mus musculus ENSMUSG00000008763   mannosidase, alpha, class 1A, member 2
Mus musculus ENSMUSG00000003746   mannosidase 1, alpha
Mus musculus ENSMUSG00000036646   mannosidase, alpha, class 1B, member 1
Oryza sativa 4338088   Os05g0209100
Oryza sativa 4336917   Os04g0606400
Saccharomyces cerevisiae YJR131W   mannosyl-oligosaccharide 1,2-alpha-mannosidase
Schistosoma japonicum Sjp_0036240   ko:K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC3.2.1.113], putative
Schistosoma japonicum Sjp_0216360   Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative
Schistosoma japonicum Sjp_0029600   Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative
Schistosoma mansoni Smp_018150   mannosyl-oligosaccharide alpha-12-mannosidase
Schmidtea mediterranea mk4.024854.00  
Schmidtea mediterranea mk4.003386.00   Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Schmidtea mediterranea mk4.003386.01  
Trichomonas vaginalis TVAG_447400   endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative
Trichomonas vaginalis TVAG_082940   conserved hypothetical protein
Trichomonas vaginalis TVAG_316770   endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative
Trichomonas vaginalis TVAG_229250   mannosyl-oligosaccharide alpha-1,2-mannosidase, putative
Trichomonas vaginalis TVAG_158080   endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative
Trichomonas vaginalis TVAG_440710   mannosyl-oligosaccharide alpha-1,2-mannosidase, putative
Trichomonas vaginalis TVAG_404080   endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative
Trichomonas vaginalis TVAG_245880   mannosyl-oligosaccharide alpha-1,2-mannosidase, putative
Trichomonas vaginalis TVAG_367080   endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative
Trichomonas vaginalis TVAG_605570   mannosyl-oligosaccharide alpha-1,2-mannosidase, putative
Trichomonas vaginalis TVAG_307800   mannosyl-oligosaccharide alpha-1,2-mannosidase, putative
Trichomonas vaginalis TVAG_586830   mannosyl-oligosaccharide alpha-1,2-mannosidase, putative
Trichomonas vaginalis TVAG_153790   endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative
Trichomonas vaginalis TVAG_362570   endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative

Essentiality

Smp_018150 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZC410.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mannosidase, alpha, class 1B, member 1 Compounds References
Drosophila melanogaster alpha Mannosidase I Compounds References
Glycine max Alpha-mannosidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0152 0.4906 0.4906
0.0154 0.2599 0.6916
0.0294 1 1
0.0057 0.4517 0.1167
0.0197 0.3295 0.2207
0.0144 1 1
0.0154 1 0.5
0.0454 0.4169 1
0.0511 0.4727 1
0.0354 1 1
0.0667 1 1
0.0057 0.4517 0.1167
0.0194 1 1
0.0057 0.4517 0.1167
0.014 1 0.5
0.0095 1 0.5
0.0057 0.4517 0.1167
0.016 0.5684 0.8228
0.0057 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_018150 (Schistosoma mansoni), mannosyl-oligosaccharide alpha-12-mannosidase
Title for this comment
Comment