Detailed view for Smp_022990

Basic information

TDR Targets ID: 282910
Schistosoma mansoni, voltage-dependent anion-selective channel
Source Database / ID:  GeneDB

pI: 9.3885 | Length (AA): 280 | MW (Da): 31927 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01459   Eukaryotic porin

Gene Ontology

Mouse over links to read term descriptions.
GO:0098656   GO:anion transmembrane transport  

GO:0005741   mitochondrial outer membrane  
GO:0008308   voltage-gated anion channel activity  
GO:0055085   transmembrane transport  
GO:0006820   anion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 280 5xdn (B) 2 283 32.00 0 0.99 1.2231 1.25
2 280 4bum (X) 3 283 33.00 0 0.85 1.27073 1.13
178 234 4xch (A) 86 135 48.00 0.2 0.25 0.318871 2.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127746)

Species Accession Gene Product
Arabidopsis thaliana AT5G57490   voltage dependent anion channel 4
Arabidopsis thaliana AT3G01280   voltage dependent anion channel 1
Arabidopsis thaliana AT5G15090   voltage dependent anion channel 3
Brugia malayi Bm1_31685   Probable voltage-dependent anion-selective channel, putative
Candida albicans CaO19.1042   outer mitochondrial membrane porin
Candida albicans CaO19.8644   outer mitochondrial membrane porin
Caenorhabditis elegans CELE_R05G6.7   Protein R05G6.7
Drosophila melanogaster Dmel_CG6647   CG6647 gene product from transcript CG6647-RB
Echinococcus granulosus EgrG_000297500   voltage dependent anion channel protein 2
Echinococcus multilocularis EmuJ_000297500   voltage dependent anion channel protein 2
Homo sapiens ENSG00000165637   voltage-dependent anion channel 2
Homo sapiens ENSG00000078668   voltage-dependent anion channel 3
Homo sapiens ENSG00000213585   voltage-dependent anion channel 1
Loa Loa (eye worm) LOAG_00456   hypothetical protein
Loa Loa (eye worm) LOAG_08386   hypothetical protein
Mus musculus ENSMUSG00000020402   voltage-dependent anion channel 1
Mus musculus ENSMUSG00000021771   voltage-dependent anion channel 2
Mus musculus ENSMUSG00000008892   voltage-dependent anion channel 3
Oryza sativa 4331551   Os03g0137500
Oryza sativa 4339446   Os05g0536200
Oryza sativa 4346851   Os09g0361400
Oryza sativa 4327665   Os01g0588200
Saccharomyces cerevisiae YNL055C   Por1p
Saccharomyces cerevisiae YIL114C   Por2p
Schistosoma japonicum Sjp_0200380   ko:K05862 voltage-dependent anion channel, putative
Schistosoma japonicum Sjp_0103420   ko:K05862 voltage-dependent anion channel, putative
Schistosoma mansoni Smp_022990   voltage-dependent anion-selective channel
Schistosoma mansoni Smp_091240.1   voltage-dependent anion-selective channel
Schistosoma mansoni Smp_091240.2   voltage-dependent anion-selective channel
Schmidtea mediterranea mk4.005932.02   Probable voltage-dependent anion-selective channel
Schmidtea mediterranea mk4.001243.09  
Schmidtea mediterranea mk4.002888.00   Probable voltage-dependent anion-selective channel
Schmidtea mediterranea mk4.009747.01  
Schmidtea mediterranea mk4.006211.00  
Schmidtea mediterranea mk4.009747.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens voltage-dependent anion channel 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.004 1 0.5
0.0041 1 0.5
0.004 1 0.5
0.0049 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_022990 (Schistosoma mansoni), voltage-dependent anion-selective channel
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