Detailed view for Smp_185160

Basic information

TDR Targets ID: 283033
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 10.2261 | Length (AA): 86 | MW (Da): 10188 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05347   Complex 1 protein (LYR family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0006120   mitochondrial electron transport, NADH to ubiquinone  
GO:0005747   mitochondrial respiratory chain complex I  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 80 5wgb (B) 4 67 30.00 0 0.8 1.21891 -1.27
20 76 5wgb (B) 8 63 36.00 0.077 0.35 1.04999 -0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130262)

Species Accession Gene Product
Arabidopsis thaliana AT4G34700   NADH-ubiquinone oxidoreductase complex 1B22
Brugia malayi Bm1_09670   NADH-ubiquinone oxidoreductase B22 subunit
Candida albicans CaO19.5547   potential mitochondrial NADH-ubiquinone oxidoreductase Complex I, LYR protein domain similar to human B22, NDUFB9 subunit
Candida albicans CaO19.12993   potential mitochondrial NADH-ubiquinone oxidoreductase Complex I, LYR protein domain similar to human B22, NDUFB9 subunit
Caenorhabditis elegans CELE_C16A3.5   Protein C16A3.5
Dictyostelium discoideum DDB_G0285021   hypothetical protein
Drosophila melanogaster Dmel_CG9306   CG9306 gene product from transcript CG9306-RA
Echinococcus granulosus EgrG_000697900   Complex 1 LYR protein
Echinococcus multilocularis EmuJ_000697900   Complex 1 LYR protein
Homo sapiens ENSG00000147684   NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
Loa Loa (eye worm) LOAG_06318   NADH-ubiquinone oxidoreductase B22 subunit
Mus musculus ENSMUSG00000022354   NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
Oryza sativa 4342058   Os06g0714100
Onchocerca volvulus OVOC1669   NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 homolog
Schistosoma japonicum Sjp_0079880   ko:K03965 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 9, putative
Schistosoma mansoni Smp_047060   hypothetical protein
Schistosoma mansoni Smp_185160   hypothetical protein
Schistosoma mansoni Smp_177970   hypothetical protein

Essentiality

Smp_185160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C16A3.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C16A3.5 Caenorhabditis elegans larval arrest wormbase
CELE_C16A3.5 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0359 0.2868 0.4668
0.0358 0.2539 0.4255
0.0366 0.2589 0.4321
0.0359 0.2868 0.4668
0.0375 0.2537 0.4181
0.0357 0.2521 0.4181
0.0362 0.255 0.3427
0.0367 0.258 0.4309
0.0383 0.2523 0.4181
0.0363 0.257 0.4296

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_185160 (Schistosoma mansoni), hypothetical protein
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