Detailed view for Smp_014080

Basic information

TDR Targets ID: 283060
Schistosoma mansoni, lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha
Source Database / ID:  GeneDB

pI: 8.2276 | Length (AA): 92 | MW (Da): 9954 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10601   LITAF-like zinc ribbon domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
49 82 5iu4 (A) 231 262 31.00 0.93 0.03 0.437065 1.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128409)

Species Accession Gene Product
Brugia malayi Bm1_36985   hypothetical protein
Brugia malayi Bm1_00175   LITAF-like protein
Brugia malayi Bm1_34810   hypothetical protein
Caenorhabditis elegans CELE_F16F9.1   Protein F16F9.1
Caenorhabditis elegans CELE_Y37D8A.8   Protein Y37D8A.8
Caenorhabditis elegans CELE_Y87G2A.19   Protein Y87G2A.19
Caenorhabditis elegans CELE_F36G3.3   Protein F36G3.3
Caenorhabditis elegans CELE_Y87G2A.18   Protein Y87G2A.18
Drosophila melanogaster Dmel_CG4250   CG4250 gene product from transcript CG4250-RB
Drosophila melanogaster Dmel_CG13510   CG13510 gene product from transcript CG13510-RC
Echinococcus granulosus EgrG_001077700   lipopolysaccharide induced transcription factor
Echinococcus granulosus EgrG_000464800   lipopolysaccharide induced tumor necrosis
Entamoeba histolytica EHI_174170   hypothetical protein
Echinococcus multilocularis EmuJ_000464400   lipopolysaccharide induced TNF alpha factor
Echinococcus multilocularis EmuJ_000464800   lipopolysaccharide induced tumor necrosis
Echinococcus multilocularis EmuJ_000464300   lipopolysaccharide induced TNF alpha factor
Echinococcus multilocularis EmuJ_000464500   lipopolysaccharide induced TNF alpha factor
Echinococcus multilocularis EmuJ_001077700   lipopolysaccharide induced transcription factor
Homo sapiens ENSG00000189067   lipopolysaccharide-induced TNF factor
Homo sapiens 101929989   lipopolysaccharide-induced tumor necrosis factor-alpha factor-like
Loa Loa (eye worm) LOAG_12629   hypothetical protein
Loa Loa (eye worm) LOAG_00475   hypothetical protein
Loa Loa (eye worm) LOAG_10240   hypothetical protein
Loa Loa (eye worm) LOAG_00476   hypothetical protein
Mus musculus ENSMUSG00000022500   LPS-induced TN factor
Mus musculus 436336   predicted gene 5767
Onchocerca volvulus OVOC394  
Onchocerca volvulus OVOC4509  
Onchocerca volvulus OVOC2418  
Onchocerca volvulus OVOC395  
Schistosoma japonicum Sjp_0028230   Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative
Schistosoma japonicum Sjp_0028250   Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN, putative
Schistosoma japonicum Sjp_0012250   hypothetical protein
Schistosoma japonicum Sjp_0095850   Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative
Schistosoma japonicum Sjp_0028240   Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative
Schistosoma japonicum Sjp_0315470   expressed protein
Schistosoma japonicum Sjp_0116140   expressed protein
Schistosoma japonicum Sjp_0307110   Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog, putative
Schistosoma mansoni Smp_060210   lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha
Schistosoma mansoni Smp_060240   lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha
Schistosoma mansoni Smp_060220   lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha
Schistosoma mansoni Smp_014080   lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha
Schistosoma mansoni Smp_025370   lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha
Schmidtea mediterranea mk4.001764.00  
Schmidtea mediterranea mk4.008464.00  
Schmidtea mediterranea mk4.017285.00   Cell death-inducing p53-target protein 1
Schmidtea mediterranea mk4.026556.00  
Schmidtea mediterranea mk4.003353.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_014080 (Schistosoma mansoni), lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha
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