pI: 12.1777 |
Length (AA): 125 |
MW (Da): 14882 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 65 | 1vq8 (V) | 1 | 62 | 34.00 | 0 | 0.84 | 1.0432 | -1.57 |
4 | 67 | 1r73 (A) | 1 | 61 | 33.00 | 0.049 | 0.95 | 0.9368 | -0.48 |
5 | 78 | 4wfa (V) | 2 | 66 | 43.00 | 0.00092 | 0.75 | 0.8358 | 0.13 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127176)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G09500 | 60S ribosomal protein L35-1 |
Arabidopsis thaliana | AT2G39390 | 60S ribosomal protein L35-2 |
Arabidopsis thaliana | AT3G55170 | 60S ribosomal protein L35-3 |
Arabidopsis thaliana | AT5G02610 | 60S ribosomal protein L35-4 |
Babesia bovis | BBOV_IV008090 | ribosomal protein L35 |
Brugia malayi | Bm1_32865 | 60S ribosomal protein L35 |
Caenorhabditis elegans | CELE_ZK652.4 | Protein RPL-35 |
Cryptosporidium hominis | Chro.30112 | 60S ribosomal protein L35 (RPL35C) |
Cryptosporidium parvum | cgd3_830 | 60S ribosomal protein L35 |
Dictyostelium discoideum | DDB_G0288349 | S60 ribosomal protein L35 |
Drosophila melanogaster | Dmel_CG4111 | Ribosomal protein L35 |
Echinococcus granulosus | EgrG_000115500 | 60S ribosomal protein L35 |
Entamoeba histolytica | EHI_042720 | 60S ribosomal protein L35, putative |
Echinococcus multilocularis | EmuJ_000115500 | 60S ribosomal protein L35 |
Giardia lamblia | GL50803_6133 | Ribosomal protein L35 |
Homo sapiens | ENSG00000136942 | ribosomal protein L35 |
Leishmania braziliensis | LbrM.26.2260 | 60S ribosomal protein L35, putative |
Leishmania braziliensis | LbrM.26.2270 | 60S ribosomal protein L35, putative |
Leishmania donovani | LdBPK_262350.1 | 60S ribosomal protein L35, putative |
Leishmania infantum | LinJ.26.2350 | 60S ribosomal protein L35, putative |
Leishmania infantum | LinJ.26.2360 | 60S ribosomal protein L35, putative |
Leishmania major | LmjF.26.2330 | 60S ribosomal protein L35, putative |
Leishmania major | LmjF.26.2340 | 60S ribosomal protein L35, putative |
Leishmania mexicana | LmxM.26.2340 | 60S ribosomal protein L35, putative |
Leishmania mexicana | LmxM.26.2330 | 60S ribosomal protein L35, putative |
Loa Loa (eye worm) | LOAG_10314 | 60S ribosomal protein L35 |
Mus musculus | 66489 | ribosomal protein L35 |
Mus musculus | 383538 | predicted gene 5258 |
Neospora caninum | NCLIV_066350 | Os06g0732000 protein, related |
Oryza sativa | 4329423 | Os02g0503400 |
Oryza sativa | 4335607 | Os04g0376000 |
Plasmodium berghei | PBANKA_0923400 | 60S ribosomal protein L35, putative |
Plasmodium falciparum | PF3D7_1124900 | 60S ribosomal protein L35, putative |
Plasmodium knowlesi | PKNH_0922800 | 60S ribosomal protein L35, putative |
Plasmodium vivax | PVX_091865 | 60S ribosomal protein L35, putative |
Plasmodium yoelii | PY03511 | ribosomal protein L29, putative |
Saccharomyces cerevisiae | YDL136W | ribosomal 60S subunit protein L35B |
Saccharomyces cerevisiae | YDL191W | ribosomal 60S subunit protein L35A |
Schistosoma japonicum | Sjp_0212910 | ko:K02918 large subunit ribosomal protein L35e, putative |
Schistosoma mansoni | Smp_004940 | 60S ribosomal protein L35 |
Schmidtea mediterranea | mk4.000632.06 | 60S ribosomal protein L35 |
Trypanosoma brucei gambiense | Tbg972.9.500 | 60S ribosomal protein L35, putative |
Trypanosoma brucei gambiense | Tbg972.9.490 | 60S ribosomal protein L35, putative |
Trypanosoma brucei | Tb927.9.1810 | 60S ribosomal protein L35, putative |
Trypanosoma brucei | Tb927.9.1850 | 60S ribosomal protein L35, putative |
Trypanosoma congolense | TcIL3000_9_400 | 60S ribosomal protein L35, putative |
Trypanosoma congolense | TcIL3000_9_390 | 60S ribosomal protein L35, putative |
Trypanosoma cruzi | TcCLB.510039.90 | 60S ribosomal protein L35, putative |
Trypanosoma cruzi | TcCLB.509979.95 | 60S ribosomal protein L35, putative |
Trypanosoma cruzi | TcCLB.509979.90 | 60S ribosomal protein L35, putative |
Toxoplasma gondii | TGME49_250810 | ribosomal protein RPL35 |
Theileria parva | TP01_0964 | 60S ribosomal protein L35, putative |
Trichomonas vaginalis | TVAG_013870 | 60S ribosomal protein L35, putative |
Trichomonas vaginalis | TVAG_158830 | 60S ribosomal protein L35, putative |
Trichomonas vaginalis | TVAG_463440 | 60S ribosomal protein L35, putative |
Trichomonas vaginalis | TVAG_347820 | 60S ribosomal protein L35, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.0700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.0700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.0700 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.160.0700 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK652.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK652.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK652.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK652.4 | Caenorhabditis elegans | sterile | wormbase |
TGME49_250810 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.