Detailed view for Smp_041390

Basic information

TDR Targets ID: 283288
Schistosoma mansoni, ubiquitin-conjugating enzyme E2 G
Source Database / ID:  GeneDB

pI: 4.4969 | Length (AA): 168 | MW (Da): 18492 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00179   Ubiquitin-conjugating enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0019787   small conjugating protein ligase activity  
GO:0051246   regulation of protein metabolic process  
GO:0043687   post-translational protein modification  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 165 3h8k (A) 2 165 79.00 0 1 2.04139 -1.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127012)

Species Accession Gene Product
Arabidopsis thaliana AT3G55380   ubiquitin-conjugating enzyme E2 14
Arabidopsis thaliana AT3G46460   ubiquitin-conjugating enzyme E2 13
Arabidopsis thaliana AT5G59300   ubiquitin conjugating enzyme E2
Babesia bovis BBOV_III009860   ubiquitin conjugating enzyme E2, putative
Brugia malayi Bm1_47630   Ubiquitin-conjugating enzyme E2 G2
Brugia malayi Bm1_18280   ubiquitin-conjugating enzyme E2-19 kDa
Candida albicans CaO19.7329   ubiquitin conjugating enzyme
Caenorhabditis elegans CELE_F58A4.10   Protein UBC-7
Caenorhabditis elegans CELE_Y87G2A.9   Protein UBC-14
Cryptosporidium hominis Chro.10052   ubiquitin conjugating enzyme E2
Cryptosporidium parvum cgd1_410   ubiquitin conjugating enzyme
Dictyostelium discoideum DDB_G0280347   ubiquitin-conjugating enzyme E2
Dictyostelium discoideum DDB_G0271726   hypothetical protein
Drosophila melanogaster Dmel_CG4443   courtless
Drosophila melanogaster Dmel_CG40045   CG40045 gene product from transcript CG40045-RB
Drosophila melanogaster Dmel_CG9602   CG9602 gene product from transcript CG9602-RA
Echinococcus granulosus EgrG_000244500   ubiquitin conjugating enzyme E2 G1
Echinococcus granulosus EgrG_000262300   ubiquitin conjugating enzyme E2 G2
Entamoeba histolytica EHI_124480   ubiquitin-conjugating enzyme family protein
Entamoeba histolytica EHI_048700   ubiquitin-conjugating enzyme family protein
Echinococcus multilocularis EmuJ_000244500   ubiquitin conjugating enzyme E2 G1
Echinococcus multilocularis EmuJ_000262300   ubiquitin conjugating enzyme E2 G2
Giardia lamblia GL50803_3171   UBCE14
Homo sapiens ENSG00000184787   ubiquitin-conjugating enzyme E2G 2
Homo sapiens ENSG00000132388   ubiquitin-conjugating enzyme E2G 1
Loa Loa (eye worm) LOAG_01940   ubiquitin-conjugating enzyme E2 7
Loa Loa (eye worm) LOAG_00879   ubiquitin-conjugating enzyme E
Loa Loa (eye worm) LOAG_05352   UBC-14 protein
Mus musculus ENSMUSG00000020794   ubiquitin-conjugating enzyme E2G 1
Mus musculus ENSMUSG00000009293   ubiquitin-conjugating enzyme E2G 2
Neospora caninum NCLIV_022090   Ubiquitin carrier protein (EC 6.3.2.-), related
Oryza sativa 4327386   Os01g0839700
Oryza sativa 4339013   Os05g0460200
Plasmodium berghei PBANKA_0821900   ubiquitin-conjugating enzyme E2, putative
Plasmodium falciparum PF3D7_0921000   ubiquitin-conjugating enzyme E2, putative
Plasmodium knowlesi PKNH_0719000   ubiquitin-conjugating enzyme E2, putative
Plasmodium vivax PVX_099465   ubiquitin-conjugating enzyme E2, putative
Plasmodium yoelii PY03603   Ubiquitin carrier protein-related
Saccharomyces cerevisiae YMR022W   E2 ubiquitin-conjugating protein UBC7
Schistosoma japonicum Sjp_0029340   ko:K10575 ubiquitin-conjugating enzyme E2 G1, putative
Schistosoma japonicum Sjp_0306520   ko:K04555 ubiquitin-conjugating enzyme E2 G2, putative
Schistosoma mansoni Smp_028100.2   ubiquitin-conjugating enzyme E2 G
Schistosoma mansoni Smp_041390   ubiquitin-conjugating enzyme E2 G
Schistosoma mansoni Smp_028100.1   ubiquitin-conjugating enzyme E2 G
Schmidtea mediterranea mk4.009548.00   Ubiquitin-conjugating enzyme E2 G2
Schmidtea mediterranea mk4.002996.00  
Schmidtea mediterranea mk4.001448.00   Ubiquitin-conjugating enzyme E2 G2
Trypanosoma brucei gambiense Tbg972.11.15870   ubiquitin-conjugating enzyme e2, putative,ubiquitin carrier protein, putative,ubiquitin-protein ligase, putative
Trypanosoma brucei Tb927.11.14200   ubiquitin-conjugating enzyme E2, putative
Trypanosoma congolense TcIL3000.11.14520   ubiquitin-conjugating enzyme E2, putative
Trypanosoma cruzi TcCLB.511727.40   ubiquitin-conjugating enzyme E2, putative
Toxoplasma gondii TGME49_202820   ubiquitin-conjugating enzyme subfamily protein
Trichomonas vaginalis TVAG_318940   ubiquitin-conjugating enzyme E2 G, putative

Essentiality

Smp_041390 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.5790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.5790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.5790 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.5790 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F58A4.10 Caenorhabditis elegans slow growth wormbase
CELE_Y87G2A.9 Caenorhabditis elegans embryonic lethal wormbase
TGME49_202820 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_041390 (Schistosoma mansoni), ubiquitin-conjugating enzyme E2 G
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