pI: 7.3489 |
Length (AA): 1076 |
MW (Da): 125913 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
71 | 759 | 1akn (A) | 5 | 545 | 25.00 | 0 | 1 | 0.580035 | 0.73 |
877 | 988 | 3kvt (A) | 9 | 111 | 44.00 | 0 | 1 | 0.597789 | -0.41 |
877 | 1075 | 2r9r (H) | 32 | 206 | 33.00 | 0 | 0.65 | 0.120644 | 1.32 |
878 | 973 | 1exb (E) | 37 | 124 | 34.00 | 0.000041 | 0.95 | 0.429819 | -0.29 |
878 | 987 | 1t1d (A) | 66 | 162 | 34.00 | 0 | 0.97 | 0.39533 | -0.55 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_172328)
Species | Accession | Gene Product |
---|---|---|
Schistosoma japonicum | Sjp_0111710 | IPR002018,Carboxylesterase, type B,domain-containing |
Schistosoma japonicum | Sjp_0106950 | IPR002018,Carboxylesterase, type B,domain-containing |
Schistosoma japonicum | Sjp_0008850 | Neuroligin-4, X-linked precursor, putative |
Schistosoma mansoni | Smp_141510 | family S9 non-peptidase homologue (S09 family) |
Schmidtea mediterranea | mk4.000802.06 | |
Schmidtea mediterranea | mk4.000802.05 | Family S9 non-peptidase homologue |
Schmidtea mediterranea | mk4.006235.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | 633 aa | 24.9% | 622 aa | Compounds | References |
Bos taurus | Cholesterol esterase | 597 aa | 23.7% | 657 aa | Compounds | References |
Torpedo californica | Acetylcholinesterase | 586 aa | 24.4% | 602 aa | Compounds | References |
Rattus norvegicus | Acetylcholinesterase | 614 aa | 24.3% | 602 aa | Compounds | References |
Anopheles gambiae | Acetylcholinesterase | 737 aa | 24.2% | 636 aa | Compounds | References |
Bos taurus | Acetylcholinesterase | 613 aa | 23.6% | 601 aa | Compounds | References |
Musca domestica | Acetylcholinesterase | 692 aa | 22.0% | 590 aa | Compounds | References |
Rattus norvegicus | Butyrylcholinesterase | 597 aa | 25.2% | 591 aa | Compounds | References |
Equus caballus | Butyrylcholinesterase | 602 aa | 25.3% | 590 aa | Compounds | References |
Laodelphax striatella | Acetylcholinesterase | 426 aa | 27.3% | 362 aa | Compounds | References |
Equus caballus | Cholinesterase | 574 aa | 25.1% | 590 aa | Compounds | References |