Detailed view for Smp_195010

Basic information

TDR Targets ID: 283708
Schistosoma mansoni, hydroxymethylglutaryl-CoA synthase
Source Database / ID:  GeneDB

pI: 4.3767 | Length (AA): 180 | MW (Da): 19220 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01154   Hydroxymethylglutaryl-coenzyme A synthase N terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0004421   hydroxymethylglutaryl-CoA synthase activity  
GO:0003824   catalytic activity  
GO:0008299   isoprenoid biosynthetic process  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 180 2wya (A) 51 229 63.00 0 1 1.75939 -0.57
5 180 2p8u (A) 16 192 65.00 0 1 1.75978 -0.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127526)

Species Accession Gene Product
Arabidopsis thaliana AT4G11820   Hydroxymethylglutaryl-CoA synthase
Candida albicans CaO19.7312   3-hydroxy-3-methylglutaryl coenzyme A synthase
Caenorhabditis elegans CELE_F25B4.6   Protein HMGS-1
Dictyostelium discoideum DDB_G0288461   hydroxymethylglutaryl-CoA synthase
Dictyostelium discoideum DDB_G0274871   hypothetical protein
Drosophila melanogaster Dmel_CG4311   HMG Coenzyme A synthase
Echinococcus granulosus EgrG_000283100   hydroxymethylglutaryl coenzyme A synthase
Echinococcus multilocularis EmuJ_000283100   hydroxymethylglutaryl coenzyme A synthase
Giardia lamblia GL50803_13962   Hydroxymethylglutaryl-CoA synthase
Homo sapiens ENSG00000134240   3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Homo sapiens ENSG00000112972   3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Leishmania braziliensis LbrM.24.2190   hypothetical protein, conserved
Leishmania donovani LdBPK_242200.1   3-hydroxy-3-methylglutaryl-CoA synthase, putative
Leishmania infantum LinJ.24.2200   hypothetical protein, conserved
Leishmania major LmjF.24.2110   hypothetical protein, conserved
Leishmania mexicana LmxM.24.2110   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_12671   cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase
Mus musculus ENSMUSG00000093930   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Mus musculus ENSMUSG00000027875   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Oryza sativa 4346215   Os08g0544900
Oryza sativa 4331418   Os03g0118800
Oryza sativa 4347614   Os09g0521400
Saccharomyces cerevisiae YML126C   hydroxymethylglutaryl-CoA synthase
Schistosoma mansoni Smp_195010   hydroxymethylglutaryl-CoA synthase
Schmidtea mediterranea mk4.002981.04   Hydroxymethylglutaryl-CoA synthase
Schmidtea mediterranea mk4.002981.02   HMG-CoA synthase
Trypanosoma brucei gambiense Tbg972.8.6150   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.6110   3-hydroxy-3-methylglutaryl-CoA synthase, putative
Trypanosoma congolense TcIL3000_8_5930   3-hydroxy-3-methylglutaryl-CoA synthase, putative
Trypanosoma cruzi TcCLB.511903.40   3-hydroxy-3-methylglutaryl-CoA synthase, putative
Trichomonas vaginalis TVAG_438940   hydroxymethylglutaryl-CoA synthase, putative
Trichomonas vaginalis TVAG_304570   hydroxymethylglutaryl-CoA synthase, putative

Essentiality

Smp_195010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6110 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.6110 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.6110 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.8.6110 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F25B4.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F25B4.6 Caenorhabditis elegans larval arrest wormbase
CELE_F25B4.6 Caenorhabditis elegans larval lethal wormbase
CELE_F25B4.6 Caenorhabditis elegans slow growth wormbase
CELE_F25B4.6 Caenorhabditis elegans sterile wormbase
YML126C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus HMG-CoA synthase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_195010 (Schistosoma mansoni), hydroxymethylglutaryl-CoA synthase
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