Detailed view for Smp_046060.1
Basic information
TDR Targets ID: 283737
Schistosoma mansoni, myosin heavy chain type B
Source Database / ID: GeneDB
Schistosoma mansoni, myosin heavy chain type B
Source Database / ID: GeneDB
pI: 5.9123 |
Length (AA): 1961 |
MW (Da): 227700 |
Paralog Number:
7
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
Mouse over links to read term descriptions.
GO:0016459
myosin complex GO:0008017 microtubule binding
GO:0005524 ATP binding
GO:0005515 protein binding
GO:0003777 microtubule motor activity
GO:0003774 motor activity
GO:0051015 actin filament binding
GO:0007018 microtubule-based movement
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 21 | 820 | 1br1 (A) | 21 | 821 | 65.00 | 0 | 1 | 0.893655 | -0.31 |
| 28 | 1038 | 1g8x (A) | 28 | 1008 | 39.00 | 0 | 1 | 0.715253 | -0.19 |
| 29 | 1053 | 1g8x (A) | 29 | 999 | 42.00 | 0 | 1 | 0.918993 | -0.08 |
| 30 | 948 | 5i4e (A) | 51 | 967 | 58.00 | 0 | 1 | 1.10794 | -0.51 |
| 31 | 814 | 5w1a (A) | 34 | 807 | 49.00 | 0 | 1 | 0.960096 | -0.62 |
| 799 | 850 | 2bl0 (A) | 788 | 839 | 48.00 | 0.0017 | 0.86 | 0.527817 | 0.33 |
| 859 | 1079 | 5cwp (A) | 1 | 226 | 15.00 | 0 | 0.25 | 0.215398 | -1.94 |
| 861 | 1887 | 5b43 (A) | 31 | 1059 | 12.00 | 0 | 0.96 | 0.268412 | 1.28 |
| 1043 | 1282 | 2yfa (A) | 48 | 281 | 12.00 | 0 | 0.79 | 0.189087 | -1.54 |
| 1094 | 1743 | 1avc (A) | 23 | 669 | 15.00 | 0 | 1 | 0.118164 | 0.8 |
| 1904 | 1961 | 5y06 (A) | 95 | 152 | 12.00 | 0.69 | 0 | 0.202977 | -1.09 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126577)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT5G20490 | Myosin XI K |
| Arabidopsis thaliana | AT4G27370 | myosin heavy chain-like protein |
| Arabidopsis thaliana | AT2G31900 | myosin-like protein XIF |
| Arabidopsis thaliana | AT5G54280 | myosin 2 |
| Arabidopsis thaliana | AT2G33240 | myosin XI D |
| Arabidopsis thaliana | AT1G08730 | myosin class XI |
| Arabidopsis thaliana | AT4G33200 | myosin-15 |
| Arabidopsis thaliana | AT1G54560 | Myosin family protein with Dil domain |
| Arabidopsis thaliana | AT1G17580 | myosin 1 |
| Arabidopsis thaliana | AT3G19960 | myosin 1 |
| Arabidopsis thaliana | AT2G20290 | myosin-like protein XIG |
| Arabidopsis thaliana | AT1G50360 | myosin VIIIA |
| Arabidopsis thaliana | AT3G58160 | Class XI myosin |
| Arabidopsis thaliana | AT5G43900 | myosin 2 |
| Arabidopsis thaliana | AT4G28710 | myosin XI H |
| Arabidopsis thaliana | AT1G04160 | myosin XI B |
| Arabidopsis thaliana | AT1G04600 | myosin XI A |
| Babesia bovis | BBOV_IV011050 | WD40 repeat myosin-like protein, putative |
| Brugia malayi | Bm1_04450 | Paramyosin |
| Brugia malayi | Bm1_00655 | myosin heavy chain, nonmuscle type 1 |
| Brugia malayi | Bm1_00935 | myosin heavy chain B (MHC B) |
| Brugia malayi | Bm1_18445 | heavy chain, unconventional myosin protein 2 |
| Brugia malayi | Bm1_50805 | Myosin tail family protein |
| Brugia malayi | Bm1_14060 | myosin heavy chain B (MHC B) |
| Brugia malayi | Bm1_51435 | Myosin tail family protein |
| Brugia malayi | Bm1_40715 | myosin heavy chain |
| Brugia malayi | Bm1_35670 | Myosin tail family protein |
| Candida albicans | CaO19.6294 | class II myosin heavy chain |
| Candida albicans | CaO19.5015 | myosin 1 isoform |
| Candida albicans | CaO19.1128 | N terminus of MYO1, class II myosin |
| Candida albicans | CaO19.13673 | class II myosin heavy chain |
| Candida albicans | CaO19.12482 | myosin 1 isoform |
| Caenorhabditis elegans | CELE_F07A5.7 | Protein UNC-15, isoform B |
| Caenorhabditis elegans | CELE_K12F2.1 | Protein MYO-3 |
| Caenorhabditis elegans | CELE_F20G4.3 | Protein NMY-2 |
| Caenorhabditis elegans | CELE_Y11D7A.14 | Protein HUM-9 |
| Caenorhabditis elegans | CELE_F52B10.1 | Protein NMY-1 |
| Caenorhabditis elegans | CELE_F36D4.3 | Protein HUM-2, isoform F |
| Caenorhabditis elegans | CELE_F45G2.2 | Protein MYO-6, isoform B |
| Caenorhabditis elegans | CELE_F58G4.1 | Protein MYO-5 |
| Caenorhabditis elegans | CELE_T18D3.4 | Protein MYO-2 |
| Caenorhabditis elegans | CELE_R06C7.10 | Protein MYO-1 |
| Caenorhabditis elegans | CELE_F11C3.3 | Protein UNC-54 |
| Cryptosporidium hominis | Chro.60523 | WD40 repeat myosin-like protein |
| Cryptosporidium hominis | Chro.60497 | myosin-related protein |
| Cryptosporidium parvum | cgd6_4340 | myosin-related protein, putative |
| Cryptosporidium parvum | cgd6_4560 | myosinmyosin |
| Dictyostelium discoideum | DDB_G0289447 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0292742 | C2 calcium/lipid-binding region-containing protein |
| Dictyostelium discoideum | DDB_G0286355 | myosin II heavy chain |
| Dictyostelium discoideum | DDB_G0272112 | hypothetical protein |
| Drosophila melanogaster | Dmel_CG15792 | zipper |
| Drosophila melanogaster | Dmel_CG17927 | Myosin heavy chain |
| Drosophila melanogaster | Dmel_CG2146 | dilute class unconventional myosin |
| Echinococcus granulosus | EgrG_000639400 | myosin va |
| Echinococcus granulosus | EgrG_000479300 | myosin heavy chain non muscle |
| Echinococcus granulosus | EgrG_000920900 | myosin heavy chain |
| Entamoeba histolytica | EHI_110180 | myosin heavy chain |
| Echinococcus multilocularis | EmuJ_000639400 | myosin va |
| Echinococcus multilocularis | EmuJ_000920900 | myosin heavy chain |
| Echinococcus multilocularis | EmuJ_000479300 | myosin heavy chain, non muscle |
| Giardia lamblia | GL50803_137716 | Axoneme-associated protein GASP-180 |
| Homo sapiens | ENSG00000105357 | myosin, heavy chain 14, non-muscle |
| Homo sapiens | ENSG00000133026 | myosin, heavy chain 10, non-muscle |
| Homo sapiens | ENSG00000167306 | myosin VB |
| Homo sapiens | ENSG00000092054 | myosin, heavy chain 7, cardiac muscle, beta |
| Homo sapiens | ENSG00000109063 | myosin, heavy chain 3, skeletal muscle, embryonic |
| Homo sapiens | ENSG00000144821 | myosin, heavy chain 15 |
| Homo sapiens | ENSG00000006788 | myosin, heavy chain 13, skeletal muscle |
| Homo sapiens | ENSG00000109061 | myosin, heavy chain 1, skeletal muscle, adult |
| Homo sapiens | ENSG00000133392 | myosin, heavy chain 11, smooth muscle |
| Homo sapiens | ENSG00000197616 | myosin, heavy chain 6, cardiac muscle, alpha |
| Homo sapiens | ENSG00000133020 | myosin, heavy chain 8, skeletal muscle, perinatal |
| Homo sapiens | ENSG00000100345 | myosin, heavy chain 9, non-muscle |
| Homo sapiens | ENSG00000125414 | myosin, heavy chain 2, skeletal muscle, adult |
| Homo sapiens | ENSG00000264424 | myosin, heavy chain 4, skeletal muscle |
| Homo sapiens | ENSG00000197535 | myosin VA (heavy chain 12, myoxin) |
| Homo sapiens | ENSG00000078814 | myosin, heavy chain 7B, cardiac muscle, beta |
| Homo sapiens | ENSG00000128833 | myosin VC |
| Leishmania braziliensis | LbrM.32.4110 | myosin XXI |
| Leishmania donovani | LdBPK_324020.1 | myosin XXI |
| Leishmania infantum | LinJ.32.4020 | myosin XXI |
| Leishmania major | LmjF.32.3870 | myosin XXI |
| Leishmania mexicana | LmxM.31.3870 | myosin heavy chain, putative |
| Loa Loa (eye worm) | LOAG_02408 | myosin |
| Loa Loa (eye worm) | LOAG_09985 | myosin-Vb |
| Loa Loa (eye worm) | LOAG_14867 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_03562 | myosin heavy chain |
| Loa Loa (eye worm) | LOAG_16019 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_13551 | myosin heavy chain B |
| Loa Loa (eye worm) | LOAG_00720 | myosin heavy chain |
| Loa Loa (eye worm) | LOAG_09961 | myosin heavy chain |
| Loa Loa (eye worm) | LOAG_07143 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_08128 | myosin heavy chain |
| Loa Loa (eye worm) | LOAG_15855 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_15916 | thoracic myosin heavy chain |
| Loa Loa (eye worm) | LOAG_15233 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_15843 | myosin heavy chain IIb isoform |
| Loa Loa (eye worm) | LOAG_16225 | MYO-2 |
| Loa Loa (eye worm) | LOAG_11632 | myosin tail family protein |
| Loa Loa (eye worm) | LOAG_10523 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_13859 | filarial antigen |
| Loa Loa (eye worm) | LOAG_14556 | myosin I |
| Loa Loa (eye worm) | LOAG_09659 | myosin heavy chain |
| Loa Loa (eye worm) | LOAG_05509 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_09386 | myosin |
| Loa Loa (eye worm) | LOAG_14181 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_00722 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_04086 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_15226 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_00721 | myosin I |
| Loa Loa (eye worm) | LOAG_15434 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_14428 | hypothetical protein |
| Mus musculus | ENSMUSG00000074652 | myosin, heavy chain 7B, cardiac muscle, beta |
| Mus musculus | ENSMUSG00000056328 | myosin, heavy polypeptide 1, skeletal muscle, adult |
| Mus musculus | ENSMUSG00000053093 | myosin, heavy polypeptide 7, cardiac muscle, beta |
| Mus musculus | ENSMUSG00000025885 | myosin VB |
| Mus musculus | ENSMUSG00000057003 | myosin, heavy polypeptide 4, skeletal muscle |
| Mus musculus | ENSMUSG00000055775 | myosin, heavy polypeptide 8, skeletal muscle, perinatal |
| Mus musculus | ENSMUSG00000022443 | myosin, heavy polypeptide 9, non-muscle |
| Mus musculus | ENSMUSG00000030739 | myosin, heavy polypeptide 14 |
| Mus musculus | ENSMUSG00000018830 | myosin, heavy polypeptide 11, smooth muscle |
| Mus musculus | ENSMUSG00000060180 | myosin, heavy polypeptide 13, skeletal muscle |
| Mus musculus | ENSMUSG00000040752 | myosin, heavy polypeptide 6, cardiac muscle, alpha |
| Mus musculus | ENSMUSG00000020908 | myosin, heavy polypeptide 3, skeletal muscle, embryonic |
| Mus musculus | ENSMUSG00000034593 | myosin VA |
| Mus musculus | ENSMUSG00000033196 | myosin, heavy polypeptide 2, skeletal muscle, adult |
| Mus musculus | ENSMUSG00000020900 | myosin, heavy polypeptide 10, non-muscle |
| Mus musculus | ENSMUSG00000092009 | myosin, heavy chain 15 |
| Mus musculus | ENSMUSG00000033590 | myosin VC |
| Mus musculus | 102642883 | myosin-14-like |
| Neospora caninum | NCLIV_067140 | Myosin, related |
| Neospora caninum | NCLIV_057670 | myosin G, putative |
| Neospora caninum | NCLIV_031350 | myosin head motor domain-containing protein TgMyo I, putative |
| Oryza sativa | 9271937 | Os12g0633700 |
| Oryza sativa | 4348961 | Os10g0488800 |
| Oryza sativa | 4348352 | Os10g0339400 |
| Oryza sativa | 9270181 | Os10g0339332 |
| Oryza sativa | 4331144 | Os02g0816900 |
| Oryza sativa | 4341074 | Os06g0488200 |
| Oryza sativa | 4330906 | Os02g0777700 |
| Oryza sativa | 4343605 | Os07g0562800 |
| Oryza sativa | 4334102 | Os03g0747900 |
| Oryza sativa | 9271693 | Os03g0686300 |
| Oryza sativa | 4334867 | Os03g0860700 |
| Onchocerca volvulus | OVOC10147 |
|
| Onchocerca volvulus | OVOC11299 |
|
| Plasmodium berghei | PBANKA_1344100 | myosin C, putative |
| Plasmodium falciparum | PF3D7_1329100 | myosin C |
| Plasmodium yoelii | PY01039 | myosin PfM-C-related |
| Saccharomyces cerevisiae | YOR326W | myosin 2 |
| Saccharomyces cerevisiae | YHR023W | myosin 1 |
| Saccharomyces cerevisiae | YAL029C | myosin 4 |
| Schistosoma japonicum | Sjp_0134610 | Myosin heavy chain, striated muscle, putative |
| Schistosoma japonicum | Sjp_0054830 | ko:K10352 myosin heavy chain, putative |
| Schistosoma japonicum | Sjp_0314070 | expressed protein |
| Schistosoma japonicum | Sjp_0131210 | Myosin-2, putative |
| Schistosoma japonicum | Sjp_0035730 | ko:K10352 myosin heavy chain, putative |
| Schistosoma mansoni | Smp_085540.1 | myosin heavy chain |
| Schistosoma mansoni | Smp_085540.6 | myosin heavy chain |
| Schistosoma mansoni | Smp_046060.1 | myosin heavy chain type B |
| Schistosoma mansoni | Smp_085540.2 | myosin heavy chain |
| Schistosoma mansoni | Smp_085540.4 | myosin heavy chain |
| Schistosoma mansoni | Smp_046060.2 | myosin heavy chain IIb |
| Schistosoma mansoni | Smp_085540.3 | myosin heavy chain |
| Schistosoma mansoni | Smp_085540.5 | myosin heavy chain |
| Schmidtea mediterranea | mk4.001142.01 | Myosin heavy chain, putative |
| Schmidtea mediterranea | mk4.001898.01 | |
| Schmidtea mediterranea | mk4.000656.03 | |
| Schmidtea mediterranea | mk4.036649.01 | |
| Schmidtea mediterranea | mk4.006259.02 | |
| Schmidtea mediterranea | mk4.006551.02 | |
| Schmidtea mediterranea | mk4.010650.00 | Myosin heavy chain A |
| Schmidtea mediterranea | mk4.009513.00 | |
| Schmidtea mediterranea | mk4.021111.00 | Hum-2 |
| Schmidtea mediterranea | mk4.001750.01 | |
| Schmidtea mediterranea | mk4.025917.00 | Hum-2 |
| Schmidtea mediterranea | mk4.016590.04 | |
| Schmidtea mediterranea | mk4.028179.00 | Hum-2 |
| Schmidtea mediterranea | mk4.037604.00 | Hum-2 |
| Schmidtea mediterranea | mk4.006303.03 | Unconventional myosin-X |
| Schmidtea mediterranea | mk4.016590.00 | |
| Schmidtea mediterranea | mk4.011151.00 | |
| Schmidtea mediterranea | mk4.001750.00 | |
| Schmidtea mediterranea | mk4.014257.00 | |
| Schmidtea mediterranea | mk4.016590.05 | |
| Schmidtea mediterranea | mk4.006551.01 | |
| Schmidtea mediterranea | mk4.000161.14 | Unconventional myosin-X |
| Schmidtea mediterranea | mk4.002646.05 | |
| Schmidtea mediterranea | mk4.024019.02 | |
| Schmidtea mediterranea | mk4.000092.10 | |
| Schmidtea mediterranea | mk4.000523.02 | |
| Schmidtea mediterranea | mk4.032313.00 | Histone H2A |
| Schmidtea mediterranea | mk4.012489.00 | |
| Schmidtea mediterranea | mk4.035446.00 | Myosin heavy chain, putative |
| Schmidtea mediterranea | mk4.043453.00 | Myosin heavy chain, putative |
| Schmidtea mediterranea | mk4.001750.02 | Putative myosin-10 |
| Schmidtea mediterranea | mk4.001952.10 | |
| Schmidtea mediterranea | mk4.009102.01 | Myosin heavy chain, putative |
| Schmidtea mediterranea | mk4.011004.03 | |
| Schmidtea mediterranea | mk4.008977.03 | |
| Schmidtea mediterranea | mk4.017672.01 | |
| Schmidtea mediterranea | mk4.001142.00 | Myosin heavy chain, putative |
| Schmidtea mediterranea | mk4.009102.02 | |
| Schmidtea mediterranea | mk4.014118.01 | |
| Schmidtea mediterranea | mk4.005080.06 | Myosin heavy chain, putative |
| Schmidtea mediterranea | mk4.027959.00 | Hum-2 |
| Schmidtea mediterranea | mk4.003074.02 | |
| Schmidtea mediterranea | mk4.010850.01 | |
| Schmidtea mediterranea | mk4.000981.01 | |
| Schmidtea mediterranea | mk4.005084.04 | Unconventional myosin-X |
| Schmidtea mediterranea | mk4.010997.02 | |
| Schmidtea mediterranea | mk4.006332.03 | Unconventional myosin-X |
| Schmidtea mediterranea | mk4.011151.01 | |
| Schmidtea mediterranea | mk4.033364.00 | Hum-2 |
| Schmidtea mediterranea | mk4.011708.00 | |
| Schmidtea mediterranea | mk4.002866.00 | |
| Schmidtea mediterranea | mk4.000086.03 | |
| Schmidtea mediterranea | mk4.018363.00 | |
| Schmidtea mediterranea | mk4.003331.01 | |
| Schmidtea mediterranea | mk4.025235.00 | |
| Schmidtea mediterranea | mk4.007776.03 | |
| Schmidtea mediterranea | mk4.006259.01 | Unconventional myosin-X |
| Schmidtea mediterranea | mk4.011402.00 | |
| Schmidtea mediterranea | mk4.016590.01 | |
| Schmidtea mediterranea | mk4.010850.02 | |
| Schmidtea mediterranea | mk4.070485.02 | |
| Schmidtea mediterranea | mk4.016590.02 | |
| Schmidtea mediterranea | mk4.010850.00 | Hum-2 |
| Schmidtea mediterranea | mk4.000060.08 | |
| Schmidtea mediterranea | mk4.017672.02 | |
| Schmidtea mediterranea | mk4.006303.04 | |
| Trypanosoma brucei gambiense | Tbg972.11.18310 | myosin, putative,myosin heavy chain, putative |
| Trypanosoma brucei | Tb927.11.16310 | Unconventional myosin |
| Trypanosoma cruzi | TcCLB.504103.30 | myosin heavy chain, putative |
| Trypanosoma cruzi | TcCLB.511151.100 | Unconventional myosin |
| Trypanosoma cruzi | TcCLB.511649.80 | myosin heavy chain, putative |
| Trypanosoma cruzi | TcCLB.506779.190 | Unconventional myosin |
| Trypanosoma cruzi | TcCLB.511527.70 | Unconventional myosin |
| Trypanosoma cruzi | TcCLB.507811.120 | myosin heavy chain MYA2-related, putative |
| Trypanosoma cruzi | TcCLB.504867.120 | hypothetical protein |
| Trypanosoma cruzi | TcCLB.503847.20 | myosin heavy chain, putative |
| Trypanosoma cruzi | TcCLB.510943.190 | myosin heavy chain MYA2-related, putative |
| Toxoplasma gondii | TGME49_230980 | myosin I |
| Toxoplasma gondii | TGME49_278870 | myosin F |
| Toxoplasma gondii | TGME49_314780 | myosin G |
| Treponema pallidum | TP0408 | hypothetical protein |
| Theileria parva | TP01_0774 | myosin, putative |
Essentiality
Smp_046060.1 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb11.01.7990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb11.01.7990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb11.01.7990 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb11.01.7990 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_R06C7.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_R06C7.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_R06C7.10 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_R06C7.10 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T18D3.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_T18D3.4 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K12F2.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K12F2.1 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F52B10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F52B10.1 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F20G4.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F20G4.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F20G4.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F20G4.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F07A5.7 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F07A5.7 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F07A5.7 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F11C3.3 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F11C3.3 | Caenorhabditis elegans | larval arrest | wormbase |
| YHR023W | Saccharomyces cerevisiae | inviable | yeastgenome |
| YOR326W | Saccharomyces cerevisiae | inviable | yeastgenome |
| TGME49_230980 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_278870 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_314780 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_230980 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_278870 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_314780 | Toxoplasma gondii | Probably essential | sidik |
-
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Gallus gallus | Myosin-Va | Compounds | References |
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
No user comments are available for this gene.
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