Detailed view for Smp_061870

Basic information

TDR Targets ID: 284436
Schistosoma mansoni, ubiquinol--cytochrome C reductase
Source Database / ID:  GeneDB

pI: 9.0737 | Length (AA): 270 | MW (Da): 29888 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00355   Rieske [2Fe-2S] domain
PF02921   Ubiquinol cytochrome reductase transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0051537   2 iron, 2 sulfur cluster binding  
GO:0016679   oxidoreductase activity, acting on diphenols and related substances as donors  
GO:0016020   membrane  
GO:0016491   oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0008121   ubiquinol-cytochrome-c reductase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
73 270 2a06 (E) 1 196 53.00 0 1 1.34753 -0.1
175 269 5cxm (A) 40 131 25.00 0 0.55 0.649952 -0.39
208 268 3azc (A) 104 162 41.00 0.0021 0.95 0.679926 -0.01
211 256 1jm1 (A) 139 196 59.00 0.0061 0.99 0.53857 -0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127574)

Species Accession Gene Product
Arabidopsis thaliana AT5G13430   ubiquinol-cytochrome C reductase iron-sulfur subunit
Arabidopsis thaliana AT5G13440   ubiquinol-cytochrome C reductase iron-sulfur subunit
Babesia bovis BBOV_III009930   ubiquinol cytochrome c oxidoreductase, putative
Brugia malayi Bm1_46150   ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein
Brugia malayi Bm1_46185   ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein
Candida albicans CaO19.13314   similar to S. cerevisiae RIP1 (YEL024W) mitochondrial cytochrome bc1 complex Rieske iron-sulfur protein
Candida albicans CaO19.5893   similar to S. cerevisiae RIP1 (YEL024W) mitochondrial cytochrome bc1 complex Rieske iron-sulfur protein
Caenorhabditis elegans CELE_F42G8.12   Protein ISP-1
Dictyostelium discoideum DDB_G0284947   Rieske iron-sulfur protein
Drosophila melanogaster Dmel_CG7361   Rieske iron-sulfur protein
Echinococcus granulosus EgrG_000421550   ubiquinol cytochrome c reductase Rieske
Echinococcus multilocularis EmuJ_000421550   ubiquinol cytochrome c reductase, Rieske
Homo sapiens 7386   ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Leishmania braziliensis LbrM.34.1450   reiske iron-sulfur protein precursor, putative
Leishmania donovani LdBPK_351540.1   rieske iron-sulfur protein, mitochondrial precursor, putative
Leishmania infantum LinJ.35.1540   reiske iron-sulfur protein precursor, putative
Leishmania major LmjF.35.1540   reiske iron-sulfur protein precursor, putative
Leishmania mexicana LmxM.34.1540   reiske iron-sulfur protein precursor, putative
Loa Loa (eye worm) LOAG_09948   ubiquinol-cytochrome c reductase
Loa Loa (eye worm) LOAG_08023   hypothetical protein
Mus musculus ENSMUSG00000038462   ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Neospora caninum NCLIV_010020   Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC 1.10.2.2), related
Oryza sativa 4329497   Os02g0520800
Oryza sativa 4335710   Os04g0398500
Plasmodium berghei PBANKA_1303300   cytochrome b-c1 complex subunit Rieske, putative
Plasmodium falciparum PF3D7_1439400   cytochrome b-c1 complex subunit Rieske, putative
Plasmodium knowlesi PKNH_1242900   cytochrome b-c1 complex subunit Rieske, putative
Plasmodium vivax PVX_118520   ubiquinol cytochrome c oxidoreductase, putative
Plasmodium yoelii PY05634   ubiquinol-cytochrome c reductase, iron-sulfur subunit, putative
Saccharomyces cerevisiae YEL024W   ubiquinol--cytochrome-c reductase catalytic subunit RIP1
Schistosoma japonicum Sjp_0217930   ko:K00411 ubiquinol-cytochrome c reductase iron-sulfur subunit, putative
Schistosoma mansoni Smp_061870   ubiquinol--cytochrome C reductase
Schmidtea mediterranea mk4.000449.05   Cytochrome b-c1 complex subunit Rieske, mitochondrial
Trypanosoma brucei gambiense Tbg972.9.8870   reiske iron-sulfur protein, mitochondrial precursor
Trypanosoma brucei Tb927.9.14160   rieske iron-sulfur protein, mitochondrial precursor
Trypanosoma congolense TcIL3000_9_6080   rieske iron-sulfur protein, mitochondrial precursor
Trypanosoma cruzi TcCLB.510759.120   rieske iron-sulfur protein, mitochondrial precursor, putative
Trypanosoma cruzi TcCLB.506999.90   rieske iron-sulfur protein, mitochondrial precursor, putative
Toxoplasma gondii TGME49_320220   ubiquinol cytochrome c oxidoreductase, putative
Theileria parva TP04_0913   ubiquinol-cytochrome C reductase, iron-sulfur subunit, putative
Wolbachia endosymbiont of Brugia malayi Wbm0406   Rieske Fe-S protein

Essentiality

Smp_061870 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.4700 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.4700 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.4700 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.4700 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F42G8.12 Caenorhabditis elegans embryonic lethal wormbase
TGME49_320220 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum cytochrome b-c1 complex subunit Rieske, putative Compounds References
Botryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytiscinerea) Cytochrome b-c1 complex subunit Rieske, mitochondrial Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0325 0.3827 0.3827
0.0523 0.5024 1
0.0537 1 1
0.0516 0.5958 0.5958
0.0413 0.5103 1
0.0325 0.3827 0.3827
0.1143 1 0.5
0.0516 0.5958 0.5958
0.0084 1 1
0.0516 0.5958 0.5958
0.0499 0.5351 1
0.0462 0.5759 1
0.0359 1 1
0.008 0.9165 1
0.0268 1 1
0.0523 0.5024 1
0.0357 1 0.5
0.0462 0.5759 1
0.0513 0.3502 1
0.16 0.3703 0.3887
0.0516 0.5958 0.5958
0.0609 0.6077 1
0.0166 0.344 0.4589
0.0551 1 0.5
0.0099 1 1
0.0325 0.3827 0.3827
0.0516 0.5958 0.5958
0.0516 0.5958 0.5958
0.0168 0.6348 0.9857
0.0516 0.5958 0.5958
0.0754 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_061870 (Schistosoma mansoni), ubiquinol--cytochrome C reductase
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