Detailed view for Smp_012720

Basic information

TDR Targets ID: 285745
Schistosoma mansoni, coronin
Source Database / ID:  GeneDB

pI: 7.0797 | Length (AA): 537 | MW (Da): 60231 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF08953   Domain of unknown function (DUF1899)
PF16300   Type of WD40 repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 402 2aq5 (A) 9 402 60.00 0 1 1.49723 -1.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126943)

Species Accession Gene Product
Babesia bovis BBOV_III008710   WD domain, G-beta repeat containing protein
Brugia malayi Bm1_44715   Coronin-like protein
Candida albicans CaO19.6535   coronin, actin-binding protein
Candida albicans CaO19.13888   coronin, actin-binding protein
Candida albicans CaO19_6535   hypothetical protein
Caenorhabditis elegans CELE_R01H10.3   Protein COR-1, isoform C
Cryptosporidium hominis Chro.70487   coronin
Cryptosporidium parvum cgd7_4400   coronin-type WD40 protein
Dictyostelium discoideum DDB_G0267382   WD-40 repeat-containing protein
Drosophila melanogaster Dmel_CG9446   CG9446 gene product from transcript CG9446-RA
Echinococcus granulosus EgrG_000294400   coronin actin binding protein 1C
Echinococcus granulosus EgrG_000258300   coronin 1C
Echinococcus granulosus EgrG_001056750   WD40 repeat subgroup
Entamoeba histolytica EHI_083590   coronin, putative
Entamoeba histolytica EHI_105330   coronin, putative
Echinococcus multilocularis EmuJ_001056750   WD40 repeat, subgroup
Echinococcus multilocularis EmuJ_000294400   coronin, actin binding protein, 1C
Echinococcus multilocularis EmuJ_000258300   coronin 1C
Homo sapiens ENSG00000102879   coronin, actin binding protein, 1A
Homo sapiens ENSG00000110880   coronin, actin binding protein, 1C
Homo sapiens ENSG00000172725   coronin, actin binding protein, 1B
Homo sapiens ENSG00000103647   coronin, actin binding protein, 2B
Homo sapiens ENSG00000167549   coronin 6
Homo sapiens ENSG00000106789   coronin, actin binding protein, 2A
Leishmania braziliensis LbrM.23.1260   coronin, putative
Leishmania donovani LdBPK_231400.1   coronin, putative
Leishmania infantum LinJ.23.1400   coronin
Leishmania major LmjF.23.1165   coronin, putative
Leishmania mexicana LmxM.23.1165   coronin, putative
Loa Loa (eye worm) LOAG_05172   hypothetical protein
Loa Loa (eye worm) LOAG_08004   hypothetical protein
Mus musculus ENSMUSG00000024835   coronin, actin binding protein 1B
Mus musculus ENSMUSG00000041729   coronin, actin binding protein, 2B
Mus musculus ENSMUSG00000030707   coronin, actin binding protein 1A
Mus musculus ENSMUSG00000028337   coronin, actin binding protein 2A
Mus musculus ENSMUSG00000004530   coronin, actin binding protein 1C
Mus musculus ENSMUSG00000020836   coronin 6
Neospora caninum NCLIV_059340   hypothetical protein, conserved
Plasmodium berghei PBANKA_1464100   coronin
Plasmodium falciparum PF3D7_1251200   coronin
Plasmodium knowlesi PKNH_1471200   coronin, putative
Plasmodium vivax PVX_101450   coronin, putative
Plasmodium yoelii PY01337   Coronin
Saccharomyces cerevisiae YLR429W   Crn1p
Schistosoma japonicum Sjp_0113860   expressed protein
Schistosoma japonicum Sjp_0022510   Coronin-1B, putative
Schistosoma mansoni Smp_012720   coronin
Schmidtea mediterranea mk4.000079.05   Coronin-like protein cor-1
Schmidtea mediterranea mk4.000017.22   Coronin-like protein cor-1
Schmidtea mediterranea mk4.000296.05   Coronin-like protein cor-1
Trypanosoma brucei gambiense Tbg972.8.2810   coronin, putative
Trypanosoma brucei Tb927.8.3100   coronin, putative
Trypanosoma cruzi TcCLB.510515.100   coronin, putative
Trypanosoma cruzi TcCLB.509859.80   coronin, putative
Toxoplasma gondii TGME49_216970   coronin, putative
Theileria parva TP04_0772   coronin, putative
Trichomonas vaginalis TVAG_177180   WD-repeat protein, putative
Trichomonas vaginalis TVAG_222320   WD-repeat protein, putative
Trichomonas vaginalis TVAG_124870   WD-repeat protein, putative

Essentiality

Smp_012720 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.3100 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.3100 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.3100 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.3100 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_216970 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_012720 (Schistosoma mansoni), coronin
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