pI: 7.0797 |
Length (AA): 537 |
MW (Da): 60231 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 402 | 2aq5 (A) | 9 | 402 | 60.00 | 0 | 1 | 1.49723 | -1.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126943)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_III008710 | WD domain, G-beta repeat containing protein |
Brugia malayi | Bm1_44715 | Coronin-like protein |
Candida albicans | CaO19.6535 | coronin, actin-binding protein |
Candida albicans | CaO19.13888 | coronin, actin-binding protein |
Candida albicans | CaO19_6535 | hypothetical protein |
Caenorhabditis elegans | CELE_R01H10.3 | Protein COR-1, isoform C |
Cryptosporidium hominis | Chro.70487 | coronin |
Cryptosporidium parvum | cgd7_4400 | coronin-type WD40 protein |
Dictyostelium discoideum | DDB_G0267382 | WD-40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG9446 | CG9446 gene product from transcript CG9446-RA |
Echinococcus granulosus | EgrG_000294400 | coronin actin binding protein 1C |
Echinococcus granulosus | EgrG_000258300 | coronin 1C |
Echinococcus granulosus | EgrG_001056750 | WD40 repeat subgroup |
Entamoeba histolytica | EHI_083590 | coronin, putative |
Entamoeba histolytica | EHI_105330 | coronin, putative |
Echinococcus multilocularis | EmuJ_001056750 | WD40 repeat, subgroup |
Echinococcus multilocularis | EmuJ_000294400 | coronin, actin binding protein, 1C |
Echinococcus multilocularis | EmuJ_000258300 | coronin 1C |
Homo sapiens | ENSG00000102879 | coronin, actin binding protein, 1A |
Homo sapiens | ENSG00000110880 | coronin, actin binding protein, 1C |
Homo sapiens | ENSG00000172725 | coronin, actin binding protein, 1B |
Homo sapiens | ENSG00000103647 | coronin, actin binding protein, 2B |
Homo sapiens | ENSG00000167549 | coronin 6 |
Homo sapiens | ENSG00000106789 | coronin, actin binding protein, 2A |
Leishmania braziliensis | LbrM.23.1260 | coronin, putative |
Leishmania donovani | LdBPK_231400.1 | coronin, putative |
Leishmania infantum | LinJ.23.1400 | coronin |
Leishmania major | LmjF.23.1165 | coronin, putative |
Leishmania mexicana | LmxM.23.1165 | coronin, putative |
Loa Loa (eye worm) | LOAG_05172 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08004 | hypothetical protein |
Mus musculus | ENSMUSG00000024835 | coronin, actin binding protein 1B |
Mus musculus | ENSMUSG00000041729 | coronin, actin binding protein, 2B |
Mus musculus | ENSMUSG00000030707 | coronin, actin binding protein 1A |
Mus musculus | ENSMUSG00000028337 | coronin, actin binding protein 2A |
Mus musculus | ENSMUSG00000004530 | coronin, actin binding protein 1C |
Mus musculus | ENSMUSG00000020836 | coronin 6 |
Neospora caninum | NCLIV_059340 | hypothetical protein, conserved |
Plasmodium berghei | PBANKA_1464100 | coronin |
Plasmodium falciparum | PF3D7_1251200 | coronin |
Plasmodium knowlesi | PKNH_1471200 | coronin, putative |
Plasmodium vivax | PVX_101450 | coronin, putative |
Plasmodium yoelii | PY01337 | Coronin |
Saccharomyces cerevisiae | YLR429W | Crn1p |
Schistosoma japonicum | Sjp_0113860 | expressed protein |
Schistosoma japonicum | Sjp_0022510 | Coronin-1B, putative |
Schistosoma mansoni | Smp_012720 | coronin |
Schmidtea mediterranea | mk4.000079.05 | Coronin-like protein cor-1 |
Schmidtea mediterranea | mk4.000017.22 | Coronin-like protein cor-1 |
Schmidtea mediterranea | mk4.000296.05 | Coronin-like protein cor-1 |
Trypanosoma brucei gambiense | Tbg972.8.2810 | coronin, putative |
Trypanosoma brucei | Tb927.8.3100 | coronin, putative |
Trypanosoma cruzi | TcCLB.510515.100 | coronin, putative |
Trypanosoma cruzi | TcCLB.509859.80 | coronin, putative |
Toxoplasma gondii | TGME49_216970 | coronin, putative |
Theileria parva | TP04_0772 | coronin, putative |
Trichomonas vaginalis | TVAG_177180 | WD-repeat protein, putative |
Trichomonas vaginalis | TVAG_222320 | WD-repeat protein, putative |
Trichomonas vaginalis | TVAG_124870 | WD-repeat protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3100 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3100 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_216970 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.